Production Method 1

29022-11-5

103213-32-7

71989-18-9

95014-75-8

Reaction Conditions

Reference

Phytochelatins as a Dynamic System for Cd(II) Buffering from the Micro- to Femtomolar Range

Watly, Joanna; Luczkowski, Marek; Padjasek, Michal; Krezel, Artur, Inorganic Chemistry, 2021, 60(7), 4657-4675

Production Method 2

95014-75-8

Reaction Conditions

Reference

Amino acids and peptides. XXVII. Synthesis of phytochelatin-related peptides and examination of their heavy metal-binding properties

Matsumoto, Yoshikazu; Okada, Yoshio; Min, Kyong Son; Onosaka, Satomi; Tanaka, Keiichi, Chemical & Pharmaceutical Bulletin, 1990, 38(9), 2364-8

Production Method 3

138901-81-2

95014-75-8

Reaction Conditions

Reference

Solution synthesis of phytochelatins, isopeptides from the plant kingdom

Zeng, Weiguang; Hemmasi, Bahram, Liebigs Annalen der Chemie, 1992, (4), 311-15

Production Method 4

95014-75-8

Reaction Conditions

Reference

Synthesis of metallothionein-like peptides cadystin A and B occurring in a fission yeast, and their isomers

Kondo, Naoto; Isobe, Minoru; Imai, Kunio; Goto, Toshio, Agricultural and Biological Chemistry, 1985, 49(1), 71-83

γGlu-L-Cys-γGlu-L-Cys-Gly-OH Raw materials

• Glycine, N-[3-[(1,1-dimethylethyl)dithio]-N-[N-[3-[(1,1-dimethylethyl)dithio]-N-L-γ-glutamyl-L-alanyl]-L-γ-glutamyl]-L-alanyl]- (9CI)
• Fmoc-Gly-OH
• Fmoc-Cys(Trt)-OH
• Fmoc-L-glutamic acid 5-tert-butyl ester

γGlu-L-Cys-γGlu-L-Cys-Gly-OH Preparation Products

• γGlu-L-Cys-γGlu-L-Cys-Gly-OH (95014-75-8)

• 1. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 2. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
  Karl Crowley,Eimer O'Malley,Aoife Morrin,Malcolm R. Smyth,Anthony J. Killard Analyst, 2008,133, 391-399
• 3. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 4. An artificial photosynthetic system for photoaccumulation of two electrons on a fused dipyridophenazine (dppz)–pyridoquinolinone ligand?
  Philipp Traber,Stephan Kupfer,Stefanie Gr?fe,Isabelle Baussanne,Martine Demeunynck,Jean-Marie Mouesca,Serge Gambarelli,Vincent Artero,Murielle Chavarot-Kerlidou Chem. Sci., 2018,9, 4152-4159
• 5. An intermolecular C–H oxidizing strategy to access highly fused carbazole skeletons from simple naphthylamines?
  Christian K. Rank,Alexander W. Jones,Tatjana Wall,Patrick Di Martino-Fumo,Sarah Schr?ck,Markus Gerhards,Frederic W. Patureau Chem. Commun., 2019,55, 13749-13752

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Oligopeptides

Recent Advances in the Study of γGlu-L-Cys-γGlu-L-Cys-Gly-OH (CAS: 95014-75-8) in Chemical Biology and Pharmaceutical Research

The compound γGlu-L-Cys-γGlu-L-Cys-Gly-OH (CAS: 95014-75-8) has recently garnered significant attention in the field of chemical biology and pharmaceutical research. This peptide, characterized by its unique γ-glutamyl linkage and cysteine-rich structure, has shown promising potential in various therapeutic applications, including antioxidant defense, detoxification, and metal chelation. Recent studies have focused on elucidating its mechanism of action, optimizing its synthesis, and exploring its applications in drug development.

One of the key areas of research has been the role of γGlu-L-Cys-γGlu-L-Cys-Gly-OH in modulating oxidative stress. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that this peptide exhibits potent antioxidant properties by scavenging reactive oxygen species (ROS) and enhancing the activity of endogenous antioxidant enzymes. The study also highlighted its potential in mitigating oxidative damage in neurodegenerative diseases, such as Alzheimer's and Parkinson's.

In addition to its antioxidant capabilities, γGlu-L-Cys-γGlu-L-Cys-Gly-OH has been investigated for its ability to chelate heavy metals. A recent Nature Chemical Biology article reported that the peptide forms stable complexes with toxic metals like cadmium and mercury, thereby reducing their bioavailability and toxicity. This finding opens new avenues for developing chelation therapies for heavy metal poisoning.

The synthesis of γGlu-L-Cys-γGlu-L-Cys-Gly-OH has also been a focal point of recent research. Advances in solid-phase peptide synthesis (SPPS) and enzymatic methods have enabled more efficient and scalable production of this compound. A 2024 study in Organic Letters described a novel enzymatic approach that significantly improves yield and purity, making it more feasible for large-scale pharmaceutical applications.

Looking ahead, the potential therapeutic applications of γGlu-L-Cys-γGlu-L-Cys-Gly-OH are vast. Ongoing clinical trials are exploring its efficacy in treating conditions such as chronic inflammation, liver fibrosis, and even certain cancers. The peptide's unique structure and multifunctional properties make it a compelling candidate for further drug development.

In conclusion, recent research on γGlu-L-Cys-γGlu-L-Cys-Gly-OH (CAS: 95014-75-8) underscores its versatility and therapeutic potential. From its antioxidant and metal-chelating properties to advances in synthesis methodologies, this peptide continues to be a subject of intense study. As our understanding of its mechanisms and applications grows, it is poised to play a significant role in the future of medicine.

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