Cas no 95-23-8 (5-Amino-1,3-dihydro-2H-benzimidazol-2-one)

5-Amino-1,3-dihydro-2H-benzimidazol-2-one structure
95-23-8 structure
Product Name:5-Amino-1,3-dihydro-2H-benzimidazol-2-one
CAS No:95-23-8
MF:C7H7N3O
MW:149.149980783463
MDL:MFCD00053555
CID:34785
PubChem ID:87559033
Update Time:2024-10-25

5-Amino-1,3-dihydro-2H-benzimidazol-2-one Chemical and Physical Properties

Names and Identifiers

    • 5-Amino-1,3-dihydro-2H-benzimidazol-2-one
    • 5-Aminobenzimidazolone
    • 5-Amino-2-benzimidazolinone
    • 5-Amino-1,3-dihydro-benzoimidazol-2-one
    • 5-AMINOBENZOIMIDAZOLONE
    • 2H-BENZIMIDAZOL-2-ONE,5-AMINO-1,3-DIHYDRO-
    • 5(6)-AMINOBENZOIMIDAZOLONE
    • 5-Amino-1,3-dihydrobenzoimidazol-2-one
    • 5-Amino-2-benzimidazolinon
    • 5-AMino-2-enziMidazolinone
    • 5-AMINO-6-CHLOROBENZOIMINDAZOLONE
    • 5-AMINOBENZIMIDAZOLIDINONE
    • 5-AMINOBENZIMIDAZOLINONE
    • 2-Benzimidazolinone,5-amino- (7CI,8CI)
    • 2-Hydroxy-5-aminobenzimidazole
    • 5-Amino-1,3-dihydrobenzimidazol-2-one
    • 5-Amino-2(3H)-benzimidazolone
    • 5-Amino-2-hydroxybenzimidazole
    • 5-Amino-2-oxo-2,3-dihydro-1H-benzimidazole
    • 2H-Benzimidazol-2-one, 5-amino-1,3-dihydro-
    • 5-amino-1H-benzo[d]imidazol-2(3H)-one
    • 5-amino-2,3-dihydro-1H-1,3-benzodiazol-2-one
    • 3V3FDT3X0M
    • BCXSVFBDMPSKPT-UHFFFAOYSA-N
    • 5-amino-3-hydrobenzimidazol-2-one
    • 5-Amino-1,3-dihydro-2H-benzimidaz
    • 2-Benzimidazolinone, 5-amino- (7CI, 8CI)
    • 5-Amino-1,3-dihydro-2H-benzimidazol-2-one (ACI)
    • 2-Oxo-2,3-dihydro-1H-benzimidazol-5-amine
    • 5-Amino-1,3-dihydro-2H-benzo[d]imidazol-2-one
    • 5-Amino-1H-benzimidazol-2(3H)-one
    • ALBB-023220
    • 5-amino-1H-benzo[d]imidazole-2(3H)-one
    • 95-23-8
    • EC 202-401-8
    • SY007179
    • NS00002356
    • EN300-02381
    • SCHEMBL92048
    • Oprea1_319016
    • CS-W019563
    • AC-10272
    • 5-amino-2-oxo-2,3-dihydro-benzimidazol
    • MFCD00053555
    • 5-AMINO-1H-BENZO[D]IMIDAZOL-2-OL
    • 2-BENZIMIDAZOLINONE, 5-AMINO-
    • DB-012237
    • EU-0078496
    • UNII-3V3FDT3X0M
    • W-100170
    • SCHEMBL1695075
    • 5-AMINOBENZIMIDAZOLIDONE
    • A1950
    • DTXSID5059119
    • DB-296024
    • Q27895420
    • Oprea1_759802
    • CL3530
    • Z56793257
    • AKOS000103534
    • 5-AMINO-1H-BENZO(D)IMIDAZOL-2(3H)-ONE
    • 40352-51-0
    • STK013932
    • AKOS008966788
    • 5-Amino-1,3-dihydro-2H-benzimidazol-2-one, AldrichCPR
    • AS-11577
    • 5-amino-1,3-dihydro-benzimidazole-2-one
    • F0074-0058
    • EINECS 202-401-8
    • 2H-1,3-Benzimidazol-2-one, 5-amino-1,3-dihydro-
    • 5-amino-1,3-dihydro-benzimidazol-2-one
    • 5-AMINO-1,3-DIHYDRO-2H-1,3-BENZIMIDAZOL-2-ONE
    • BBL028058
    • MDL： MFCD00053555
    • Inchi： 1S/C7H7N3O/c8-4-1-2-5-6(3-4)10-7(11)9-5/h1-3H,8H2,(H2,9,10,11)
    • InChI Key： BCXSVFBDMPSKPT-UHFFFAOYSA-N
    • SMILES： O=C1NC2C(=CC=C(C=2)N)N1

Computed Properties

  • Exact Mass: 149.05900
  • Monoisotopic Mass: 149.058912
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 0
  • Complexity: 183
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.4
  • Topological Polar Surface Area: 67.2
  • Surface Charge: 0
  • Tautomer Count: 3

Experimental Properties

  • Color/Form: Powder
  • Density: 1.363
  • Melting Point: 35-39°C
  • Boiling Point: 201.4℃ at 760 mmHg
  • Flash Point: 75.6℃
  • Refractive Index: 1.657
  • PSA: 74.67000
  • LogP: 1.01960
  • Solubility: Not determined
  • Sensitiveness: Easy to absorb moisture; Sensitive to humidity

5-Amino-1,3-dihydro-2H-benzimidazol-2-one Security Information

  • Symbol: GHS07
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H302-H319
  • Warning Statement： P305 + P351 + P338
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Hazard Category Code： 22-36
  • Safety Instruction： S26; S36/37/39
  • Hazardous Material Identification： Xi
  • HazardClass：IRRITANT
  • Storage Condition：Store at room temperature
  • Risk Phrases：R36/37/38

5-Amino-1,3-dihydro-2H-benzimidazol-2-one Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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5-Amino-1,3-dihydro-2H-benzimidazol-2-one Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Sodium hydroxide ,  Hydrogen Catalysts: Palladium Solvents: Water ;  pH 9; 0.3 MPa, 95 °C; 0.4 MPa, 95 °C; 2 h, 0.9 MPa, 120 °C
Reference
Method for preparing 5-aminobenzimidazolone having high purity by catalytic hydrogenation of 5-nitrobenzimidazolone
, China, , ,

Production Method 2

Reaction Conditions
1.1 Reagents: Sodium hydroxide Catalysts: Aluminum ,  Iron ,  Nickel ,  Chromium Solvents: Water ;  1.5 h, 85 - 90 °C; 1 h, 90 °C → 95 °C
1.2 Reagents: Hydrogen Solvents: Ethanol ;  rt → 95 °C; 13 h, 2 MPa, 95 °C
Reference
Process for preparation of 5-aminobenzimidazolone from reduction of 5-nitrobenzimidazolone
, China, , ,

Production Method 3

Reaction Conditions
1.1 Reagents: Sodium hydroxide ,  Potassium borohydride (non-crystalline state nickel-boron catalyst) Catalysts: Nickel acetate tetrahydrate (non-crystalline state nickel-boron catalyst) Solvents: Water ;  pH 11, 70 °C; 3 h, 70 °C; 3.5 h, 70 °C
1.2 Reagents: Hydrogen Solvents: Ethanol ;  8 h, 1.6 MPa, 110 °C
Reference
Method for preparing 5-amino-2-benzimidazolinone derivative by use of non-crystalline state nickel-boron catalyst
, China, , ,

Production Method 4

Reaction Conditions
1.1 Reagents: Diketene Catalysts: Dabco ;  rt
Reference
Acetoacetylation of alcohols, thiols and amines in a microreactor using diketene
, World Intellectual Property Organization, , ,

Production Method 5

Reaction Conditions
1.1 Reagents: Iron ,  Hydrochloric acid Solvents: Water ;  rt → 90 °C; 1 h, 100 °C
1.2 Reagents: Sodium hydroxide Catalysts: Sodium bisulfite ;  pH 9
Reference
Treatment method of 5-nitrobenzimidazolone mother liquid through iron powder reduction
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Production Method 6

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  3 h, 35 psi, rt
Reference
Preparation of isoindoline compounds for the treatment of spinal muscular atrophy and other uses
, World Intellectual Property Organization, , ,

Production Method 7

Reaction Conditions
1.1 Reagents: Hydrochloric acid
Reference
Relation of N-alkoxybenzimidazoles to nucleophilic reagents. Attempts to synthesize N-hydroxy-2-aminobenzimidazoles
Medvedeva, M. M.; Pozharskii, A. F.; Kuz'menko, V. V.; Bessonov, V. V.; Tertov, B. A., Khimiya Geterotsiklicheskikh Soedinenii, 1979, (2), 200-6

Production Method 8

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium oxide (PdO) Solvents: Ethanol ;  4 h, 1.5 MPa, 100 °C
Reference
Synthesis method of 5-amino-2-benzimidazolinone (5-ABI) as pigment intermediate by catalytic hydrogenation reduction
, China, , ,

Production Method 9

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  4 h, 2 MPa, 85 °C
Reference
Synthetic method for preparing 5-aminobenzimidazolone
, China, , ,

Production Method 10

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  2 min, 3 psi, rt; 24 h, rt
Reference
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Zhu, Haizhou; Mishra, Rosalin; Yuan, Long; Abdul Salam, Safnas F.; Liu, Jing; et al, ChemMedChem, 2019, 14(22), 1933-1939

Production Method 11

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  5 h, 1 MPa, rt → 95 °C
Reference
Process for preparation of pigment intermediate 5-aminobenzimidazolone
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Production Method 12

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Methanol ;  1 - 2 MPa, rt → 70 °C; 2 h, 1 - 2 MPa, 60 - 70 °C
Reference
Preparation of 5-amino-2-benzimidazolinone via catalytic hydrogenation of 5-nitro-2-benzimidazolinone
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Production Method 13

Reaction Conditions
1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Ethanol ;  reflux
Reference
Synthesis of 5-acetyIacetamidobenzimidazolone
Zhang, Zhenyu; Zhang, Jing; Shen, Haijiao; Ma, Jianyu; Qu, Hongmei, Huaxue Gongye Yu Gongcheng (Tianjin, 2014, 31(1), 24-27

Production Method 14

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: 1,10-Phenanthroline ,  Ferrous acetate Solvents: Tetrahydrofuran ,  Water ;  17 h, 50 bar, 120 °C
Reference
Nanoscale Fe2O3-Based Catalysts for Selective Hydrogenation of Nitroarenes to Anilines
Jagadeesh, Rajenahally V.; Surkus, Annette-Enrica; Junge, Henrik; Pohl, Marga-Martina; Radnik, Joerg; et al, Science (Washington, 2013, 342(6162), 1073-1076

Production Method 15

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol ;  8 - 15 h, 2 - 3 MPa, 90 - 95 °C
Reference
Synthesis of 5-aminobenzimidazolone-2 from 5-nitrobenzimidazolone-2 with catalyst Raney Ni
Tan, Chuanjiang; Feng, Yaqing; Gao, Pei, Jingxi Huagong, 2007, 24(8), 829-832

Production Method 16

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ,  Ethyl acetate ;  6 h, rt
Reference
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Production Method 17

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Reference
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Production Method 18

Reaction Conditions
1.1 Reagents: Ammonium vanadium oxide ((NH4)VO3) Catalysts: Palladium ,  Titania Solvents: Methanol
1.2 Reagents: Hydrogen
Reference
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Production Method 19

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  3 h, 450 Pa, 70 °C
Reference
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Moolya, Preetam N.; Gadilohar, Balu L.; Shankarling, Ganapati S., Coloration Technology, 2015, 131(2), 104-109

Production Method 20

Reaction Conditions
1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  1 h, rt
Reference
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5-Amino-1,3-dihydro-2H-benzimidazol-2-one Raw materials

5-Amino-1,3-dihydro-2H-benzimidazol-2-one Preparation Products

5-Amino-1,3-dihydro-2H-benzimidazol-2-one Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:95-23-8)5-氨基苯并咪唑酮
Order Number:LE26965303
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 13:00
Price ($):discuss personally

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Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:95-23-8)5-氨基苯并咪唑酮
LE26965303
Purity:99%
Quantity:25KG,200KG,1000KG
Price ($):Inquiry
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