Production Method 1

78-39-7

95-21-6

Reaction Conditions

1.1 Catalysts: Hydrogen (T-4)-dioxobis[sulfato(2-)-κO]tungstate(2-) (2:1) ;  9 min, 80 - 90 °C

Reference

Tungstate sulfuric acid as an efficient catalyst for the synthesis of benzoxazoles and benzothiazoles under solvent-free conditions

Farahi, Mahnaz; Karami, Bahador; Azari, Masume, Comptes Rendus Chimie, 2013, 16(11), 1029-1034

Production Method 2

1445-45-0

95-21-6

Reaction Conditions

1.1 Reagents: Acetic acid ,  Indium Solvents: Benzene ,  Water ;  1 h, reflux

Reference

Indium-mediated one-pot synthesis of benzoxazoles or oxazoles from 2-nitrophenols or 1-aryl-2-nitroethanones

Lee, Jung June; Kim, Jihye; Jun, Young Moo; Lee, Byung Min; Kim, Byeong Hyo, Tetrahedron, 2009, 65(43), 8821-8831

Production Method 3

95-21-6

Reaction Conditions

1.1 Catalysts: Phosphonic acid, P-dodecyl-, zirconium(4+) salt (2:1) ;  2 h, 100 °C
1.2 Reagents: Sodium bicarbonate Solvents: Dichloromethane ,  Water

Reference

Zirconium dodecylphosphonate: selective and constructive catalyst for preparation of 2-Alkyl benzoxazoles from aliphatic carboxylic acids

Ghassamipour, Soheila; Khadem Keshavarzi, Rasool, Iranian Journal of Chemistry & Chemical Engineering, 2017, 36(1), 27-33

Production Method 4

95-21-6

Reaction Conditions

1.1 Catalysts: p-Toluenesulfonic acid Solvents: Toluene ;  16 h, reflux

Reference

Hydrogen-bond-supported dimeric boron complexes of potentially tetradentate β-diketiminate ligands

Barbon, Stephanie M.; Staroverov, Viktor N.; Boyle, Paul D.; Gilroy, Joe B., Dalton Transactions, 2014, 43(1), 240-250

Production Method 5

78-39-7

95-21-6

Reaction Conditions

1.1 Catalysts: 1H-Imidazolium, 1-methyl-3-(3-sulfopropyl)-, tetracosa-μ-oxododecaoxo[μ12-[phosp… Solvents: Water ;  18 min, rt

Reference

A Green and Efficient Protocol for the Synthesis of Quinoxaline, Benzoxazole and Benzimidazole Derivatives Using Heteropolyanion-Based Ionic Liquids: As a Recyclable Solid Catalyst

Vahdat, Seyed Mohammad; Baghery, Saeed, Combinatorial Chemistry & High Throughput Screening, 2013, 16(8), 618-627

Production Method 6

614-80-2

95-21-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: Chloroform ;  1 h, reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 8, 0 °C

Reference

Regioselective Syntheses of 2- and 4-Formylpyrido[2,1-b]benzoxazoles

Li, Ke-Lai; Du, Zong-Bo; Guo, Can-Cheng; Chen, Qing-Yun, Journal of Organic Chemistry, 2009, 74(9), 3286-3292

Production Method 7

33047-12-0

95-21-6

Reaction Conditions

Reference

A comparison of some pyrolysis reactions of benzotriazoles, benzisoxazolones and benzisothiazolones

Janowski, Wit K.; Prager, Rolf H.; Smith, Jason A., Perkin 1, 2000, (19), 3212-3216

Production Method 8

1196-29-8

95-21-6

Reaction Conditions

1.1 Solvents: Benzene

Reference

Use of zeolite catalysts for efficient synthesis of benzoxazoles via Beckmann rearrangement

Bhawal, B. M.; Mayabhate, S. P.; Likhite, A. P.; Deshmukh, A. R. A. S., Synthetic Communications, 1995, 25(21), 3315-21

Production Method 9

1445-45-0

95-21-6

Reaction Conditions

1.1 Catalysts: Tin oxide (SnO2) (Nanoparticles) Solvents: Ethanol ;  30 min, rt

Reference

Application of nano SnO2 as a green and recyclable catalyst for the synthesis of 2-aryl or alkylbenzoxazole derivatives under ambient temperature

Vahdat, Seyed Mohammad; Raz, Shima Ghafouri; Baghery, Saeed, Journal of Chemical Sciences (Bangalore, 2014, 126(3), 579-585

Production Method 10

5467-64-1

82833-70-3

95-21-6

Reaction Conditions

Reference

Photolysis and thermolysis of phenyl azide in acetic acid

Takeuchi, Hiroshi; Koyama, Kikuhiko, Journal of the Chemical Society, 1981, (5), 202-4

Production Method 11

62-55-5

95-21-6

Reaction Conditions

1.1 Catalysts: Ferrocene, 1-(2-iodoethynyl)-2-phenyl- Solvents: Toluene ;  15 h, 90 °C

Reference

Disubstituted Ferrocenyl Iodo- and Chalcogenoalkynes as Chiral Halogen and Chalcogen Bond Donors

Mamane, Victor ; Peluso, Paola; Aubert, Emmanuel; Weiss, Robin; Wenger, Emmanuel; et al, Organometallics, 2020, 39(21), 3936-3950

Production Method 12

24823-81-2

95-21-6

Reaction Conditions

1.1 Catalysts: Sulfuric acid ;  2 min

Reference

Silica-sulfuric acid catalyzed microwave-assisted synthesis of substituted benzoxazoles and their antimicrobial activity

Anand, M.; Ranjitha, A.; Himaja, M., International Research Journal of Pharmacy, 2011, 2(4), 211-213

Production Method 13

78-39-7

95-21-6

Reaction Conditions

1.1 Catalysts: Acetic acid, 2,2,2-trifluoro-, bismuth(3+) salt (3:1) ;  2 min, rt

Reference

Mild and efficient synthesis of benzoxazoles, benzothiazoles, benzimidazoles, and oxazolo[4,5-b]pyridines catalyzed by Bi(III) salts under solvent-free conditions

Mohammadpoor-Baltork, Iraj; Khosropour, Ahmad R.; Hojati, Seyedeh F., Monatshefte fuer Chemie, 2007, 138(7), 663-667

Production Method 14

78-39-7

95-21-6

Reaction Conditions

1.1 Catalysts: 1,3-Dibromo-5,5-dimethylhydantoin ;  2 min, rt

Reference

1,3-Dibromo-5,5-dimethylhydantoin as an efficient homogeneous catalyst for synthesis of benzoxazoles, benzimidazoles, and oxazolo[4,5-b]pyridines

Hojati, Seyedeh Fatemeh; Maleki, Behrooz; Beykzadeh, Zahra, Monatshefte fuer Chemie, 2011, 142(1), 87-91

Production Method 15

78-39-7

95-21-6

Reaction Conditions

1.1 Catalysts: Sulfuric acid (silica-supported) ;  2 h, rt

Reference

Silica sulfuric acid catalyzed synthesis of benzoxazoles, benzimidazoles and oxazolo[4,5-b]pyridines under heterogeneous and solvent-free conditions

Mohammadpoor-Baltork, I.; Moghadam, M.; Tangestaninejad, S.; Mirkhani, V.; Zolfigol, M. A.; et al, Journal of the Iranian Chemical Society, 2008, 5,

Production Method 16

33047-12-0

95-21-6

Reaction Conditions

Reference

The synthesis of oxazoles by thermolysis or photolysis of 2-acyl isoxazol-5-ones

Ang, Kiah H.; Prager, Rolf H.; Smith, Jason A.; Weber, Ben; Williams, Craig M., Tetrahedron Letters, 1996, 37(5), 675-8

Production Method 17

614-80-2

95-21-6

Reaction Conditions

1.1 Reagents: Trifluoroacetic acid ,  Potassium peroxymonosulfate sulfate (2KHSO5.KHSO4.K2SO4) Solvents: 1,4-Dioxane ;  rt → 90 °C

Reference

C-H oxygenation and N-trifluoroacylation of arylamines under metal-free conditions. A convenient approach to 2-aminophenols and N-trifluoroacyl-ortho-aminophenols

Venkateswarlu, Vunnam; Kumar, K. A. Aravinda; Balgotra, Shilpi; Reddy, G. Lakshma; Srinivas, M.; et al, Chemistry - A European Journal, 2014, 20(22), 6641-6645

Production Method 18

95-21-6

Reaction Conditions

1.1 Catalysts: Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(OH)2O10.xH2O) Solvents: Acetonitrile ;  14 h, 90 °C

Reference

Metal free montmorillonite KSF clay catalyzed practical synthesis of benzoxazoles and benzothiazoles under aerobic conditions

Kummari, Vijaya Babu; Chiranjeevi, Kalavakuntla; Suman Kumar, Alleni; Aravind Kumar, Rathod; Yadav, Jhillu Singh, Synthetic Communications, 2019, 49(23), 3335-3342

Production Method 19

613-93-4

95-21-6

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Water ;  10 min

Reference

Synthesis method of benzoxazole by microwave radiation of benzamide compound in aqueous phase

, China, , ,

Production Method 20

78-39-7

95-21-6

Reaction Conditions

1.1 Catalysts: Bismuth triflate ;  3 h

Reference

Bismuth(III) trifluoromethanesulfonate

Ollevier, Thierry; Nadeau, Etienne; Desyroy, Valerie, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2009, 1, 1-6

2-Methylbenzoxazole Raw materials

• 1,1,1-Trimethoxyethane
• Acetamide,N-[2-(acetyloxy)phenyl]-
• N-Methylbenzamide
• Trimethyl orthopropionate
• 2’-Hydroxyacetophenone Oxime
• 1-Acetyl-2,1-benzisoxazol-3(1H)-one
• Triethyl orthoacetate
• Thioacetamide
• 2-Acetamidophenol
• Phenol, 2-amino-, 1-acetate

2-Methylbenzoxazole Preparation Products

• 2-Methylbenzoxazole (95-21-6)

• 1. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 2. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
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• 3. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
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• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
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• 5. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzoxazoles Benzoxazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzoxazoles
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 85-15-4(2-Methylnaphth1,2-doxazole)
• 5676-60-8(2-Methyl-1,3-benzoxazol-6-amine)
• 20686-65-1(2-Methylnaphth2,1-doxazole)
• 224298-72-0(2-Benzoxazolemethanamine,hydrochloride (1:2))
• 5676-58-4(2,5-Dimethylbenzoxazole)
• 55850-41-4(Benzo[1,2-d:5,4-d']bisoxazole,2,6-dimethyl-)
• 19219-99-9(5-chloro-2-methyl-1,3-benzoxazole)
• 20686-66-2(2-Methylnaphth2,3-doxazole)
• 53012-61-6(Benzoxazole,2,6-dimethyl-)
• 101333-98-6(1,3-benzoxazol-2-ylmethanamine)