Production Method 1

60-18-4

949-67-7

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Ethanol ;  0 °C; 1 h, 0 °C; 24 h, rt
1.2 Reagents: Ammonia Solvents: Diethyl ether ,  Water ;  2 h, neutralized, rt

Reference

Characterization and cytotoxicity evaluation of biocompatible amino acid esters used to convert salicylic acid into ionic liquids

Moshikur, Rahman Md.; Chowdhury, Raihan Md.; Wakabayashi, Rie ; Tahara, Yoshiro; Moniruzzaman, Muhammad; et al, International Journal of Pharmaceutics (Amsterdam, 2018, 546(1-2), 31-38

Production Method 2

60-18-4

949-67-7

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane Solvents: Ethanol ;  rt; 4 h, reflux

Reference

Ultrasound-Assisted Synthesis, Antifungal Activity against Fusarium oxysporum, and Three-Dimensional Quantitative Structure-Activity Relationship of N,S-Dialkyl Dithiocarbamates Derived from 2-Amino Acids

Quiroga, Diego ; Becerra, Lili Dahiana ; Coy-Barrera, Ericsson, ACS Omega, 2019, 4(9), 13710-13720

Production Method 3

60-18-4

949-67-7

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  30 min, 0 °C; 30 min; 20 min; 10 min; 2 d; 2 h, reflux
1.2 Reagents: Ammonia Solvents: Water ;  pH 8

Reference

One-pot synthesis of S-(-)-(1,1'-binaphthalene)-2,2'-diol catalyzed by Cu(II)-tyrosine ethyl ester complexes

Ma, Peng-Gao; Zhang, Ming-Jie; Yang, Qi-Chao, Youji Huaxue, 2003, 23(12), 1422-1424

Production Method 4

4089-07-0

949-67-7

Reaction Conditions

1.1 Reagents: Sodium bicarbonate Solvents: Water ;  rt; 4 h, rt

Reference

A cancer-targetable copolymer containing tyrosine segments for labeling radioactive halogens

Qi, Yu; Li, Na-Jun; Xu, Qing-Feng; Xia, Xue-Wei; Ge, Jian-Feng; et al, Reactive & Functional Polymers, 2011, 71(4), 390-394

Production Method 5

72594-77-5

949-67-7

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: N,N′-Di-tert-butylethylenediamine ,  Tetrakis(acetonitrile)copper(1+) hexafluorophosphate Solvents: Dichloromethane ;  4 h, 1 atm, 20 - 23 °C
1.2 Reagents: Disodium sulfide Solvents: Water ;  20 - 23 °C
1.3 Reagents: Sulfuric acid Solvents: Dichloromethane ,  Water ;  20 - 23 °C; 1 h, 20 - 23 °C
1.4 Reagents: Trisodium phosphate ,  Oxygen Solvents: Water ;  10 min, neutralized, 20 - 23 °C

Reference

A Bioinspired Synthesis of Polyfunctional Indoles

Huang, Zheng; Kwon, Ohhyeon; Huang, Haiyan; Fadli, Aziz; Marat, Xavier; et al, Angewandte Chemie, 2018, 57(37), 11963-11967

Production Method 6

3081-24-1

949-67-7

Reaction Conditions

1.1 Reagents: Iodine Solvents: Water ;  pH 7; 6 min, rt
1.2 30 min, 7 atm, rt

Reference

Biodistribution of 125I-labeled polymeric vaccine carriers after subcutaneous injection

Toita, Riki; Kanai, Yasukazu; Watabe, Hiroshi; Nakao, Kenshi; Yamamoto, Seiichi; et al, Bioorganic & Medicinal Chemistry, 2013, 21(17), 5310-5315

Production Method 7

60-18-4

949-67-7

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ;  rt; 24 h, 60 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  neutralized

Reference

Inhibition of acetylcholinesterase by coumarin-linked amino acids synthesized via triazole associated with molecule partition coefficient

de Sousa, Bianca L. ; Leite, Joao P. V.; Mendes, Tiago A. O.; Varejao, Eduardo V. V.; Chaves, Anna C. S.; et al, Journal of the Brazilian Chemical Society, 2021, 32(3), 652-664

Production Method 8

60-18-4

949-67-7

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  -5 °C; overnight, rt
1.2 Reagents: Potassium carbonate Solvents: Water ;  pH 8 - 9

Reference

Synthesis of tirofiban hydrochloride

Ye, Jia-lin; Li, Hong-ming; Cao, Sheng-hua; Ding, Xiao-dong, Huaxue Yanjiu Yu Yingyong, 2012, 24(5), 821-824

Production Method 9

60-18-4

949-67-7

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  rt → -10 °C; -10 - -5 °C; 2 h, 20 °C; 2 h, 70 - 80 °C
1.2 Reagents: Ammonium hydroxide Solvents: Water ;  80 °C → 0 °C; pH 8.5 - 9, 0 °C

Reference

Preparation of D-tyrosine by forming tartaric acid dityrosine ester diastereomeric salt

Peng, Yang-Feng; He, Quan; Wang, Jia-Rong; Gao, Hao-Qi; Chai, Shui-Hong; et al, Youji Huaxue, 2006, 26(1), 69-76

Production Method 10

60-18-4

949-67-7

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Ethanol ;  0 °C; 60 min, 0 °C; 0 °C → rt; overnight, rt → reflux

Reference

Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease

Kim, Minhee ; Hwang, Inseon; Pagire, Haushabhau S.; Pagire, Suvarna H.; Choi, Wonsuk; et al, Journal of Medicinal Chemistry, 2020, 63(8), 4171-4182

Production Method 11

60-18-4

949-67-7

Reaction Conditions

1.1 Catalysts: Amberlyst 15 Solvents: Ethanol

Reference

A mild and convenient procedure for the esterification of amino acids

Anand, Ramesh C.; Vimal, Synthetic Communications, 1998, 28(11), 1963-1965

Production Method 12

60-18-4

949-67-7

Reaction Conditions

1.1 Catalysts: Chlorotrimethylsilane ;  rt; 36 h, rt

Reference

Reaction Tracking and High-Throughput Screening of Active Compounds in Combinatorial Chemistry by Tandem Mass Spectrometry Molecular Networking

Chung, Hsin-Hsiang ; Kao, Chih-Yao; Wang, Tsung-Shing Andrew; Chu, John; Pei, Jiying ; et al, Analytical Chemistry (Washington, 2021, 93(4), 2456-2463

Production Method 13

60-18-4

949-67-7

Reaction Conditions

1.1 Reagents: Thionyl chloride

Reference

Stereospecific Synthesis of 3,4-Dihydro-2H-naphtho-1,4-oxazin-2-ones by Unification of Benzoxazepine-4-carboxylates with Chiral Amino Acid Ethyl Esters

Kasagani, Veera Prasad; Kurma, Siva Hariprasad; Bhimapaka, China Raju, Journal of Organic Chemistry, 2020, 85(5), 2976-2983

Production Method 14

60-18-4

949-67-7

Reaction Conditions

Reference

ProTides of BVdU as potential anticancer agents upon efficient intracellular delivery of their activated metabolites

Kandil, Sahar; Balzarini, Jan; Rat, Stephanie; Brancale, Andrea; Westwell, Andrew D.; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(23), 5618-5623

L-Tyrosine Ethyl Ester Raw materials

• L-Tyrosine
• (S)-Ethyl 2-((tert-butoxycarbonyl)amino)-3-(4-hydroxyphenyl)propanoate
• ethyl (2S)-2-amino-3-phenylpropanoate
• H-Tyr-OEt.HCl

L-Tyrosine Ethyl Ester Preparation Products

• L-Tyrosine Ethyl Ester (949-67-7)

• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Exciting clusters, what does off-resonance actually mean??
  Goonay Yousefalizadeh,Shideh Ahmadi,Nicholas J. Mosey,Kevin G. Stamplecoskie Nanoscale, 2021,13, 242-252
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 4. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 5. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 34081-17-9(ethyl 2-amino-3-(4-hydroxyphenyl)propanoate)
• 18869-47-1(Tyrosine, methyl ester)
• 1080-06-4(Methyl L-tyrosinate)
• 42406-77-9(L-Tyrosine benzyl ester)
• 16874-12-7(L-tyrosine tert-butyl ester)
• 3410-66-0(Methyl D-Tyrosinate)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)