Production Method 1

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  1 h, rt

Reference

preparation of quinazoline and quinoline derivatives as interleukin-1 receptor-associated kinases (IRAK) inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  16 h, 25 °C

Reference

Fused ring pyrimidine compound, intermediate, and preparation method, composition and use thereof

, World Intellectual Property Organization, , ,

Production Method 3

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Ethanol ;  14 h, rt

Reference

Preparation of fused pyrimidine compounds for the treatment of cancers associated with EGFR and HER2 mutations and their compositions containing them

, World Intellectual Property Organization, , ,

Production Method 4

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  15 h, rt

Reference

Pyrimidine compounds, compositions, and medicinal applications thereof

, World Intellectual Property Organization, , ,

Production Method 5

2075-46-9

948571-47-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  12 h, reflux
1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  24 h, rt

Reference

Preparation of pyrrolo[2,3-d]pyrimidine derivatives as Janus kinase inhibitors

, China, , ,

Production Method 6

2075-46-9

948571-47-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  12 h, reflux
1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  24 h, rt

Reference

4,6-disubstituted aminopyridine-based JAK kinase inhibitor and tis preparation

, China, , ,

Production Method 7

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  2 h, rt

Reference

Preparation of thiazolo[5,4-d]pyrimidine derivatives as IRAK kinase inhibitors and uses thereof

, World Intellectual Property Organization, , ,

Production Method 8

2075-46-9

948571-47-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  18 h, 60 °C; 60 °C → rt
1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  18 h, rt

Reference

Preparation of pyrazolo[4,3-c]pyridine derivatives as JAK inhibitors

, World Intellectual Property Organization, , ,

Production Method 9

2075-46-9

948571-47-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  18 h, 60 °C; 60 °C → rt
1.2 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  18 h, rt

Reference

Preparation of (7H-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as JAK3 inhibitors

, World Intellectual Property Organization, , ,

Production Method 10

42027-81-6

948571-47-9

Reaction Conditions

1.1 Solvents: Methanol

Reference

Preparation of pyrrolecarboxamide derivatives as ERK5 inhibitors for treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 11

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  3 h, rt

Reference

Structure-based design and synthesis of pyrimidine-4,6-diamine derivatives as Janus kinase 3 inhibitors

Yu, Ru-Nan; Chen, Cheng-Juan; Shu, Lei; Yin, Yuan; Wang, Zhi-Jian; et al, Bioorganic & Medicinal Chemistry, 2019, 27(8), 1646-1657

Production Method 12

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  3 h, rt

Reference

Pyrimido five-membered ring derivative and application

, World Intellectual Property Organization, , ,

Production Method 13

2075-46-9

948571-47-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  8 h, 50 °C

Reference

Preparation of 4-arylamino-6-(heteroaryl)quinazoline compounds useful as PI3k inhibitors for the treatment of cancer

, China, , ,

Production Method 14

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  12 h, 25 °C

Reference

Five-and-six-membered heterocyclic compound, its preparation method and pharmaceutical application

, World Intellectual Property Organization, , ,

Production Method 15

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Ethanol ;  12 h, rt

Reference

Substituted pyrimidine compounds, compositions and medicinal applications thereof

, India, , ,

Production Method 16

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium dihydroxide Solvents: Methanol ;  14 h, rt

Reference

Preparation of substituted pyrimidine compounds as inhibitors of epidermal growth factor receptor (EGFR) kinases for treating cancer

, World Intellectual Property Organization, , ,

Production Method 17

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  24 h, rt

Reference

Preparation of 1H-pyrazolo[3,4-d]pyrimidine derivatives as jak kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 18

42027-81-6

948571-47-9

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  24 h, rt; 24 h, rt

Reference

Preparation of substituted phenylpyrimidine derivative as JAK inhibitor for treating autoimmune disease

, China, , ,

Production Method 19

2075-46-9

948571-47-9

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  16 h, 50 °C
1.2 Reagents: Hydrogen Catalysts: Nickel Solvents: Ethanol ,  Ethyl acetate ;  5 h, rt

Reference

Preparation of pyrazole derivatives as JAK inhibitors for treatment of autoimmune disease or cancer

, World Intellectual Property Organization, , ,

2-(4-aminopyrazol-1-yl)ethanol Raw materials

• 2-(4-nitropyrazol-1-yl)ethanol
• 4-Nitropyrazole

2-(4-aminopyrazol-1-yl)ethanol Preparation Products

• 2-(4-aminopyrazol-1-yl)ethanol (948571-47-9)

• 1. Excitation dependent recombination studies on SnO2/TiO2 electrospun nanofibers?
  Veluru Jagadeesh babu,Sesha Vempati RSC Adv., 2015,5, 66367-66375
• 2. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 3. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 4. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 5. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

• 1185103-69-8(1-Propyl-1H-pyrazol-4-ylamine dihydrochloride)
• 405548-42-7(1-(2-Methylpropyl)-1H-pyrazol-4-amine)
• 948573-26-0(1-ethyl-1h-pyrazol-4-amine Hydrochloride (1:1))
• 1249733-51-4(3-(4-Amino-1h-pyrazol-1-yl)propan-1-ol hydrochloride)
• 948570-74-9(1-(2-Methoxyethyl)-1H-pyrazol-4-amine)
• 1249559-26-9(1-2-(1H-pyrazol-1-yl)ethyl-1H-pyrazol-4-amine)
• 1296308-08-1(1-(4-Amino-1H-pyrazol-1-yl)propan-2-ol)
• 1206640-59-6(1-(4-amino-1H-pyrazol-1-yl)-2-methylpropan-2-ol)
• 876343-24-7(1-Ethyl-1H-pyrazol-4-amine)
• 1006483-43-7(1-Propyl-1H-pyrazol-4-amine)