Production Method 1

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  18 h, 60 °C

Reference

Preparation of hydroxyamidine derivatives useful as indoleamine 2,3-dioxygenase inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  6 h, reflux

Reference

Structure-based design and synthesis of pyrimidine-4,6-diamine derivatives as Janus kinase 3 inhibitors

Yu, Ru-Nan; Chen, Cheng-Juan; Shu, Lei; Yin, Yuan; Wang, Zhi-Jian; et al, Bioorganic & Medicinal Chemistry, 2019, 27(8), 1646-1657

Production Method 3

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  rt; 5 h, rt → 90 °C

Reference

Preparation of substituted pyrimidine compounds as inhibitors of epidermal growth factor receptor (EGFR) kinases for treating cancer

, World Intellectual Property Organization, , ,

Production Method 4

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Triphenylphosphine ,  Di-tert-butyl azodicarboxylate Solvents: Tetrahydrofuran ;  0 °C; 4 - 16 h, rt

Reference

Preparation of pyrazole derivatives and compositions containing them for the treatment and prevention of diseases associated with hypermineralization

, World Intellectual Property Organization, , ,

Production Method 5

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  12 h, 80 °C

Reference

Preparation of sulphonyl urea derivatives as NLRP3 inflammasome modulators for the treatment of inflammatory, autoinflammatory, autoimmune and neoplastic diseases

, World Intellectual Property Organization, , ,

Production Method 6

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Solvents: Acetonitrile ;  6 h, rt → 60 °C

Reference

Preparation of substituted pyrrolopyrimidine compounds, compositions thereof, and their use in the treatment of triple negative breast cancer

, United States, , ,

Production Method 7

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  4 h, 100 °C

Reference

Preparation of heterocyclic compounds as CDK kinase inhibitors for the treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 8

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Potassium iodide Solvents: Acetonitrile ;  overnight, reflux

Reference

Preparation of 1H-pyrazolo[3,4-d]pyrimidine derivatives as jak kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 9

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  4 h, 80 °C

Reference

Preparation of pyrazolylaminopyrimidinylbenzylthiazolecarboxamide derivatives and analogs for use as Bruton's tyrosine kinase inhibitors

, World Intellectual Property Organization, , ,

Production Method 10

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  5 h, rt → 90 °C

Reference

Substituted pyrimidine compounds, compositions and medicinal applications thereof

, India, , ,

Production Method 11

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  rt → 80 °C; 16 h, 80 °C

Reference

Pyrimidine derivatives as EGFR inhibitors and their preparation, pharmaceutical compositions and use in the treatment of lung cancer

, World Intellectual Property Organization, , ,

Production Method 12

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  rt → 80 °C; 16 h, 80 °C

Reference

Pyrimidopyrazole compounds as fourth generation EGFR inhibitors

, World Intellectual Property Organization, , ,

Production Method 13

42027-81-6

948570-75-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ;  rt; 30 min, rt
1.2 rt; 16 h, rt
1.3 Solvents: Water ;  rt

Reference

Preparation of thiazolo[5,4-d]pyrimidine derivatives as IRAK kinase inhibitors and uses thereof

, World Intellectual Property Organization, , ,

Production Method 14

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Triphenylphosphine ,  Diethyl azodicarboxylate Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; 3 h, rt

Reference

Five-and-six-membered heterocyclic compound, its preparation method and pharmaceutical application

, World Intellectual Property Organization, , ,

Production Method 15

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  3 d, 60 °C

Reference

Preparation of fused pyrimidine compounds for the treatment of cancers associated with EGFR and HER2 mutations and their compositions containing them

, World Intellectual Property Organization, , ,

Production Method 16

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  16 h, 50 °C

Reference

Preparation of pyrazole derivatives as JAK inhibitors for treatment of autoimmune disease or cancer

, World Intellectual Property Organization, , ,

Production Method 17

627-42-9

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  18 h, reflux

Reference

Nitrogen-containing heteroaromatic ring derivative as tyrosine kinase inhibitor and its preparation

, World Intellectual Property Organization, , ,

Production Method 18

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  6 h, 60 °C

Reference

Discovery of 7H-pyrrolo[2,3-d]pyridine derivatives as potent FAK inhibitors: Design, synthesis, biological evaluation and molecular docking study

Wang, Ruifeng; Zhao, Xiangxin; Yu, Sijia; Chen, Yixuan; Cui, Hengxian; et al, Bioorganic Chemistry, 2020, 102,

Production Method 19

6482-24-2

2075-46-9

948570-75-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetonitrile ;  12 h, reflux

Reference

Preparation of substituted phenylpyrimidine derivative as JAK inhibitor for treating autoimmune disease

, China, , ,

1-(2-methoxyethyl)-4-nitro-pyrazole Raw materials

• 1-Bromo-2-methoxyethane
• 2-(4-nitropyrazol-1-yl)ethanol
• 1-chloro-2-methoxyethane
• 4-Nitropyrazole

1-(2-methoxyethyl)-4-nitro-pyrazole Preparation Products

• 1-(2-methoxyethyl)-4-nitro-pyrazole (948570-75-0)

• 1. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 2. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 3. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 4. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 5. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168

• 1182917-01-6(2-Methyl-1-(4-nitro-1H-pyrazol-1-yl)propan-2-ol)
• 1173061-75-0(4-Nitro-1-propyl-1H-pyrazole)
• 42027-81-6(2-(4-nitropyrazol-1-yl)ethanol)
• 97421-21-1(1-Isopropyl-4-nitro-1H-pyrazole)
• 58793-45-6(1-Ethyl-4-nitro-1H-pyrazole)
• 1002243-79-9(3-(4-Nitro-1H-pyrazol-1-yl)propanenitrile)
• 6645-69-8((4-Nitro-1H-pyrazol-1-yl)acetic acid)
• 1002033-53-5(2-(4-Nitro-1H-pyrazol-1-yl)ethylamine)
• 97421-12-0(1-(1,1-dimethylethyl)-4-nitro-1H-Pyrazole)
• 108372-40-3(4-nitro-1-[2-(4-nitropyrazol-1-yl)ethyl]pyrazole)