Production Method 1

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Triphosgene Catalysts: 4-Methyl-1-piperazinecarboxaldehyde ,  Divinylbenzene-vinylbenzyl chloride copolymer Solvents: Chlorobenzene ,  Dimethylacetamide ;  rt → 30 °C; 3 h, 30 °C

Reference

Preparation of 2,3,4,5-tetrafluorobenzoyl chloride

, China, , ,

Production Method 2

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Triphosgene Catalysts: 1-Piperazinecarboxaldehyde (bonded on Merrifield resin) Solvents: 2-Methyltetrahydrofuran ;  rt → 65 °C; 8 h, 60 - 65 °C

Reference

Process for preparation of 2,3,4,5-tetrafluorobenzoyl chloride

, China, , ,

Production Method 3

1201-31-6

94695-48-4

Reaction Conditions

Reference

Preparation of pyridinylquinolones as antibacterials

, European Patent Organization, , ,

Production Method 4

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Thionyl chloride

Reference

Preparation and testing of 9-fluoro-6-oxo-10-pyridinylpyrido[1,2,3-de][1,4]benzoxazine-6-carboxylates and -benzothiazine-6-carboxylates as antimicrobials

, European Patent Organization, , ,

Production Method 5

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Triphosgene Catalysts: Dimethylformamide Solvents: 1,2-Dichloroethane ;  1 h, 353 K; 4 h, 353 K

Reference

Facile and selective synthesis of 2,3,4,5-tetrafluorobenzoyl chloride with triphosgene

Yang, Juhong; Han, Xiaoxiang; Zhou, Lingxiao; Xiong, Chunhua, Asian Journal of Chemistry, 2011, 23(4), 1615-1617

Production Method 6

652-03-9

94695-48-4

Reaction Conditions

1.1 Reagents: Tributylamine ;  rt → 120 °C; 2 h, 120 °C; 120 °C → 60 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 14, 60 °C
1.3 Reagents: Sulfuric acid Solvents: Water ;  pH 1, cooled
1.4 Reagents: Thionyl chloride ;  rt; rt → 70 °C; 3 h, 70 °C; 70 °C → 85 °C; 5 h, 85 °C

Reference

A method for preparing 2,3,4,5-tetrafluorobenzoyl chloride

, China, , ,

Production Method 7

157766-28-4

94695-48-4

Reaction Conditions

1.1 Reagents: Water Catalysts: Iron chloride (FeCl3) ;  120 °C

Reference

Process for preparation of multiply halogenated benzotrichlorides and benzoyl chlorides, and new trihalobenzotrichlorides and -benzoyl chlorides, useful for preparation of quinolinecarboxylic acid antibacterials

, Germany, , ,

Production Method 8

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride

Reference

3,28-Bis-O-polyfluorobenzoylbetulin. Synthesis, Molecular Structure, and Cytotoxicity

Trishin, Yu. G.; Fedorov, A. N.; Lyssenko, K. A.; Prokof'eva, D. S.; Rudenok, Yu. S.; et al, Russian Journal of Organic Chemistry, 2018, 54(10), 1480-1485

Production Method 9

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  16 h, 22 °C

Reference

Quantification of Small Molecule-Protein Interactions using FRET between Tryptophan and the Pacific Blue Fluorophore

Lee, Molly M.; Peterson, Blake R., ACS Omega, 2016, 1(6), 1266-1276

Production Method 10

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Benzene ;  1 h, rt; 4 - 6 h, reflux

Reference

Antimycobacterial and antimicrobial studies of newly synthesized 3-(4-(6-methylbenzo[d]thiazol-2-yl) phenyl)quinazolin-4(3H)-ones

Shaikh, Asif R.; Patel, Navin B.; Rajani, Dhanji, Indian Journal of Research in Pharmacy and Biotechnology, 2014, 2(1), 935-942

Production Method 11

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Dimethylformamide ;  rt → 70 °C

Reference

Preparation method of tetrafluorobenzyl alcohol

, China, , ,

Production Method 12

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Diethyl ether ;  0.5 h, 0 °C; overnight, rt

Reference

Preparation method of levofloxacin hydrochloride

, China, , ,

Production Method 13

1201-31-6

94695-48-4

Reaction Conditions

1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane ;  rt → 0 °C
1.2 Reagents: Thionyl chloride ;  0 °C; 0 °C → rt; overnight, rt

Reference

Process for preparation of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-[(4aS,7aS)-octahydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid

, China, , ,

Production Method 14

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Dimethylformamide ;  rt → 90 °C; 6 - 8 h

Reference

Synthetic process for the preparation of levofloxacin hemihydrate from levofloxacin

, World Intellectual Property Organization, , ,

Production Method 15

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Dimethylformamide ,  Toluene ;  55 - 60 °C

Reference

Quinolone dimers as potential antibacterial agents

Chepyala, Naveenkumar R.; Durgi, Rajashaker R.; Tatini, Lakshmi K.; Subbaraju, Gottumukkala V.; Hindupur, Rama M.; et al, Letters in Organic Chemistry, 2011, 8(9), 637-643

Production Method 16

94695-48-4

Reaction Conditions

1.1 Reagents: Potassium fluoride Catalysts: Tetramethylammonium chloride Solvents: Toluene ;  rt → 100 °C; 0.4 MPa, 100 °C → 150 °C; 5 h, 120 - 150 °C; 150 °C → 50 °C
1.2 Reagents: Sodium carbonate ,  Water ;  rt → 80 °C; 5 h, 75 - 80 °C; 80 °C → 30 °C
1.3 Reagents: Thionyl chloride ;  45 °C; 2 h, 45 °C; 45 °C → 80 °C; 3 h, 75 - 80 °C

Reference

Efficient green synthesis method of 2,3,4,5-tetrafluorobenzoyl chloride for producing levofloxacin

, China, , ,

Production Method 17

94695-48-4

Reaction Conditions

1.1 Reagents: Sodium tetrafluoroborate Solvents: Water ;  cooled

Reference

A novel synthesis of quinolone-ofloxacin

Jha, Kamlodvab; Thakur, B. G., Journal Chemtracks, 2010, 12(2), 455-462

Production Method 18

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Dimethylformamide ;  7 h, reflux

Reference

Preparation method of Marbofloxacin intermediate

, China, , ,

Production Method 19

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  2 h, rt

Reference

General C-H Arylation Strategy for the Synthesis of Tunable Visible Light-Emitting Benzo[a]imidazo[2,1,5-c,d]indolizine Fluorophores

Levesque, Eric; Bechara, William S.; Constantineau-Forget, Lea; Pelletier, Guillaume; Rachel, Natalie M.; et al, Journal of Organic Chemistry, 2017, 82(10), 5046-5067

Production Method 20

1201-31-6

94695-48-4

Reaction Conditions

1.1 Reagents: Pyridine ,  Thionyl chloride Solvents: Toluene ;  rt → reflux; reflux; 4 h, reflux

Reference

Process for preparation of ethyl 3-(N-methyl-N-benzylamino)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate

, China, , ,

2,3,4,5-Tetrafluorobenzoyl chloride Raw materials

• Tetrafluorophthalic Acid
• 1,2,3,4-tetrafluoro-5-(trichloromethyl)benzene
• 2,3,4,5-Tetrafluorobenzoic acid

2,3,4,5-Tetrafluorobenzoyl chloride Preparation Products

• 2,3,4,5-Tetrafluorobenzoyl chloride (94695-48-4)

• 1. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
• 2. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 3. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 4. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 5. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

• 72482-64-5(2,4-Difluorobenzoyl chloride)
• 88419-56-1(2,4,5-Trifluorobenzoyl chloride)
• 107535-73-9(2,3,5,6-Tetrafluorobenzoyl chloride)
• 189807-20-3(2,3,6-trifluorobenzoyl chloride)
• 261763-38-6(2,3-Difluoro-4-methylbenzoyl chloride)
• 18355-73-2(2,3-difluorobenzoyl chloride)
• 2251-50-5(Pentafluorobenzoyl chloride)
• 72480-62-7(2,4-Difluorobenzoyl chloride)
• 123016-51-3(2,3,4,6-Tetrafluorobenzoyl chloride)
• 157373-08-5(2,3,4-Trifluorobenzoyl chloride)