Production Method 1

22255-22-7

94608-23-8

Reaction Conditions

1.1 Solvents: Ethanol ;  1 h

Reference

Method for the synthesis of (Z)-3,5,4'-trimethoxystilbene, a trimethyl derivative of resveratrol, the resulting compound, and uses of said compound, in particular as a medicine, and particularly as an anticancer drug

, World Intellectual Property Organization, , ,

Production Method 2

959961-16-1

94608-23-8

Reaction Conditions

1.1 Reagents: 1,10-Phenanthroline ,  Quinoline ,  Copper ;  50 min, heated
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 6, cooled

Reference

Method for preparing diphenylethylene from 2,3-diphenyl acrylic acid

, China, , ,

Production Method 3

400608-31-3

94608-23-8

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane ,  Hydrogen ,  Magnesium Catalysts: (OC-6-31)-Aqua[1-[2,6-bis(1-methylethyl)phenyl]-3-[1-[[2,6-bis(1-methylethyl)phe… Solvents: Tetrahydrofuran ;  24 h, 90 - 100 °C

Reference

Chromium-catalyzed stereodivergent E- and Z-selective alkyne hydrogenation controlled by cyclic (alkyl)(amino)carbene ligands

Ling, Liang ; Hu, Chenyang ; Long, Linhong; Zhang, Xue ; Zhao, Lixing ; et al, Nature Communications, 2023, 14(1),

Production Method 4

959961-16-1

94608-23-8

Reaction Conditions

1.1 Reagents: Quinoline ,  Sodium hydroxide Catalysts: Copper ;  0.25 h, 200 °C

Reference

Synthesis of resveratrol

Hou, Bing-bo; Feng, Jiang-jiang; Yang, Sheng-wei; Ao, Gui-zhen, Huaxue Shiji, 2011, 33(12), 1141-1143

Production Method 5

909717-00-6

94608-23-8

Reaction Conditions

1.1 Reagents: Quinoline Catalysts: Copper ;  3 h, 220 °C

Reference

Efficient synthesis of natural polyphenolic stilbenes: resveratrol, piceatannol and oxyresveratrol

Sun, Hong-Yi; Xiao, Chun-Fen; Cai, Yu-Chen; Chen, Yu; Wei, Wen; et al, Chemical & Pharmaceutical Bulletin, 2010, 58(11), 1492-1496

Production Method 6

959961-16-1

94608-23-8

Reaction Conditions

1.1 Reagents: Quinoline ,  Copper Catalysts: 1,10-Phenanthroline ;  6 min
1.2 Reagents: Hydrochloric acid Solvents: Water ;  cooled

Reference

Microwave-assisted and ligand-accelerated decarboxylation of 2,3-diaryl acrylic acids

Liu, Xianke; Wu, Wei; Lv, Zeliang; Zou, Yong, Huaxue Tongbao, 2012, 75(6), 526-531

Production Method 7

959961-16-1

94608-23-8

Reaction Conditions

1.1 Reagents: Quinoline ,  Copper ;  3 h, 200 °C

Reference

Hydroxyl Substitutional Effect on Selective Synthesis of cis, trans Stilbenes and 3-Arylcoumarins Through Perkin Condensation

Xiao, Chun-Fen; Zou, Yong; Du, Jian-Li; Sun, Hong-Yi; Liu, Xian-Ke, Synthetic Communications, 2012, 42(9), 1243-1258

Production Method 8

1229971-87-2

696-62-8

94608-23-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Diethyl ether ;  0 °C; 0 °C → rt; 16 h, rt
1.2 Reagents: Tetrabutylammonium fluoride Catalysts: Bis(dibenzylideneacetone)palladium Solvents: Tetrahydrofuran

Reference

Diversity-oriented synthesis of disubstituted alkenes using masked silanols

Sore, Hannah F.; Blackwell, David T.; MacDonald, Simon J. F.; Spring, David R., Organic Letters, 2010, 12(12), 2806-2809

Production Method 9

22255-22-7

94608-23-8

Reaction Conditions

1.1 Solvents: Ethanol ;  1 h, rt

Reference

Anti-mitotic properties of resveratrol analog (Z)-3,5,4'-trimethoxystilbene

Chabert, Philippe; Fougerousse, Andre; Brouillard, Raymond, BioFactors, 2006, 27(1-4), 37-46

Production Method 10

1530-38-7

7311-34-4

94608-23-8

Reaction Conditions

1.1 Reagents: Lithium hydroxide Solvents: Isopropanol ;  60 °C

Reference

E-selective isomerization of stilbenes and stilbenoids through reversible hydroboration

Gray, Erin E.; Rabenold, Lake E.; Goess, Brian C., Tetrahedron Letters, 2011, 52(46), 6177-6179

Production Method 11

441351-32-2

94608-23-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  5 h, reflux

Reference

Synthesis of radiolabeled stilbene derivatives as new potential PET probes for aryl hydrocarbon receptor in cancers

Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Sledge, George W.; Hutchins, Gary D.; et al, Bioorganic & Medicinal Chemistry Letters, 2006, 16(22), 5767-5772

Production Method 12

959961-16-1

94608-23-8

Reaction Conditions

1.1 Catalysts: Chromium copper oxide (Cr2CuO4) Solvents: Pyridine ;  rt → 240 °C; 1 - 2 h, 230 - 240 °C; 240 °C → rt

Reference

Improved method for synthesizing resveratrol

, China, , ,

Production Method 13

400608-31-3

94608-23-8

Reaction Conditions

1.1 Reagents: Lithium tert-butoxide ,  Bis(neopentyl glycolato)diboron Catalysts: (2-Thiophenecarboxylato-κO2,κS1)copper ,  1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Dimethylformamide ,  Water ;  24 h, 60 °C

Reference

Copper-catalysed, diboron-mediated cis-dideuterated semihydrogenation of alkynes with heavy water

Han, Xiaowei; Hu, Jiefeng; Chen, Cheng; Yuan, Yu; Shi, Zhuangzhi, Chemical Communications (Cambridge, 2019, 55(48), 6922-6925

Production Method 14

400608-31-3

94608-23-8

Reaction Conditions

1.1 Reagents: Deuterium ,  [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]hydroxy… Catalysts: 1,1-Bis(diphenylphosphino)ferrocene ,  Nickel iodide (NiI2) Solvents: Tetrahydrofuran ;  100 bar, 60 °C

Reference

A simple nickel catalyst enables broad E-selective alkyne semihydrogenation

Thiel, Niklas O.; Kaewmee, Benyapa; Ngoc, Trung Tran; Teichert, Johannes F., ChemRxiv, 2019, 1, 1-7

Production Method 15

959961-16-1

94608-23-8

Reaction Conditions

1.1 Reagents: Quinoline ,  Potassium hydroxide ,  Copper bromide (CuBr) ;  0.5 h, 190 °C

Reference

Method for preparation of (E)-Resveratrol

, China, , ,

Production Method 16

959961-16-1

94608-23-8

Reaction Conditions

1.1 Reagents: Tributylamine Catalysts: Copper oxide (Cu2O) Solvents: N-Methyl-2-pyrrolidone ;  90 min, 200 °C

Reference

Stereospecific synthesis of cis-stilbenes from benzaldehydes and phenylacetic acids via sequential Perkin condensation and decarboxylation

Thompson, Clayton M.; Orellana, Matthew D.; Lloyd, Shannon E.; Wu, Weiming, Tetrahedron Letters, 2016, 57(43), 4866-4868

Production Method 17

20469-65-2

94608-23-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Palladium diacetate ,  2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl Solvents: Tetrahydrofuran ;  6 h, 23 °C

Reference

(Z)-(2-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis

Woerly, Eric M.; Struble, Justin R.; Palyam, Nagarjuna; O'Hara, Sean P.; Burke, Martin D., Tetrahedron, 2011, 67(24), 4333-4343

Production Method 18

959961-16-1

94608-23-8

Reaction Conditions

1.1 Reagents: Copper Solvents: Quinoline ;  4 h, 220 °C

Reference

An efficient synthesis of resveratrol and a hydroxyl derivative via the perkin reaction: cis to trans isomerization in a demethylation process

Li, Guoxing; Zou, Yong; Zhang, Xuejing, Journal of Chemical Research, 2007, (11), 657-659

Production Method 19

1530-38-7

7311-34-4

94608-23-8

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; 30 min, -78 °C; 1 h, rt; rt → -78 °C
1.2 Solvents: Tetrahydrofuran ;  1 h, -78 °C; 18 h, rt

Reference

2-Amino and 2'-Aminocombretastatin Derivatives as Potent Antimitotic Agents

Chang, Jang-Yang; Yang, Ming-Fang; Chang, Chi-Yen; Chen, Chi-Ming; Kuo, Ching-Chuan; et al, Journal of Medicinal Chemistry, 2006, 49(21), 6412-6415

Production Method 20

400608-31-3

94608-23-8

Reaction Conditions

1.1 Reagents: Hydrogen Solvents: Ethanol ;  3.3 min, 2 bar, 60 °C

Reference

Preparation of substituted electron rich diphenylacetylenes and stilbene derivatives

, World Intellectual Property Organization, , ,

cis-trismethoxy Resveratrol (Solution in Ethanol) Raw materials

• 1-Bromo-3,5-dimethoxybenzene
• Benzeneacetic acid, α-[(3,5-dimethoxyphenyl)methylene]-4-methoxy-, (αE)-
• (αE)-3,5-Dimethoxy-α-[(4-methoxyphenyl)methylene]benzeneacetic acid
• 1-[[2-(3,5-Dimethoxyphenyl)ethynyl]dimethylsilyl]-2,3,4,5,6-pentafluorobenzene
• (Z)-Pterostilbene
• (4-Methoxybenzyl)triphenylphosphonium bromide
• 4-Iodoanisole
• trans-Trimethoxyresveratrol
• Benzene, 1,3-dimethoxy-5-[(4-methoxyphenyl)ethynyl]-
• 3,5-Dimethoxybenzaldehyde

cis-trismethoxy Resveratrol (Solution in Ethanol) Preparation Products

• cis-trismethoxy Resveratrol (Solution in Ethanol) (94608-23-8)

• 1. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 2. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 3. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Stilbenes Stilbenes
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Stilbenes

• 104-46-1(Anethole)
• 25679-28-1(Cis-Anethole)
• 21956-56-9(trans-3,5-Dimethoxystilbene)
• 117048-59-6(Combretastatin A4)
• 537-42-8(Pterostilbene)
• 1142-15-0(4-Methoxystilbene)
• 4180-23-8(1-Methoxy-4-(1E)-1-propen-1-ylbenzene)
• 15638-14-9(4,4'-Dimethoxystilbene)
• 18259-15-9(Phenol,4-[2-(3,5-dimethoxyphenyl)ethenyl]-)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)