Production Method 1

499193-57-6

945717-09-9

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  -78 °C; 45 min, 0 °C

Reference

Preparation of N-benzyl benzamides, pyridinecarboxamides and pyrimidinecarboxamides as cholesteryl ester transfer protein (CETP) inhibitors for the treatment of dyslipidemia

, United States, , ,

Production Method 2

499193-57-6

945717-09-9

Reaction Conditions

1.1 Reagents: Potassium fluoride Solvents: Methanol ;  1 h, rt
1.2 Solvents: Water ;  rt

Reference

Preparation of cyclohexanecarboxamide derivatives as farnesoid X receptor agonists and uses thereof

, World Intellectual Property Organization, , ,

Production Method 3

499193-57-6

945717-09-9

Reaction Conditions

1.1 Reagents: Potassium fluoride ,  18-Crown-6 Solvents: Dichloromethane ;  5 h, rt

Reference

Visible-light-induced synthesis of a variety of trifluoromethylated alkenes from potassium vinyltrifluoroborates by photoredox catalysis

Yasu, Yusuke; Koike, Takashi; Akita, Munetaka, Chemical Communications (Cambridge, 2013, 49(20), 2037-2039

Production Method 4

499193-57-6

945717-09-9

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  -78 °C; 45 min, 0 °C

Reference

Anthranilamide/2-amino-heteroarenecarboxamide derivatives as CETP inhibitors and their preparation

, World Intellectual Property Organization, , ,

Production Method 5

499193-57-6

945717-09-9

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ,  Water ;  3 min, rt

Reference

Preparation of pyrazole derivatives as mGlu5 antagonists

, World Intellectual Property Organization, , ,

Production Method 6

499193-57-6

945717-09-9

Reaction Conditions

1.1 Reagents: Potassium fluoride Solvents: Methanol ;  3 h, rt

Reference

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

Rohrig, Ute F.; Majjigapu, Somi Reddy; Grosdidier, Aurelien; Bron, Sylvian; Stroobant, Vincent; et al, Journal of Medicinal Chemistry, 2012, 55(11), 5270-5290

2-Chloro-4-ethynylpyridine Raw materials

• 2-chloro-4-2-(trimethylsilyl)ethynylpyridine

2-Chloro-4-ethynylpyridine Preparation Products

• 2-Chloro-4-ethynylpyridine (945717-09-9)

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• 2. Acenaphthenic hopanoids, a novel series of aromatised
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  RabailGul,MariamMir,MurtazaNAli

• 42260-39-9(2-Chloro-4-phenylpyridine)
• 40325-11-9(2-Chloro-4-ethylpyridine)
• 144900-57-2((2-Chloropyridin-4-yl)methanamine)
• 3678-62-4(2-Chloro-4-methylpyridine)
• 39621-00-6(2,6-dichloro-4-methylpyridine)
• 101990-73-2(2-Chloro-4-(chloromethyl)pyridine)
• 53344-73-3(2-Chloro-4,4'-bipyridine)
• 263012-63-1(2-Chloro-5-ethynylpyridine)
• 53344-74-4(2,2'-Dichloro-4,4'bipyridine)
• 101990-72-1(2,6-Dichloro-4-(chloromethyl)pyridine)