Production Method 1

1478126-83-8

944902-88-9

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  Phosphorus oxychloride ;  16 h, 80 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 7

Reference

Preparation of fused pyrimidines as glucose uptake inhibitors for treating parasitic and viral infections

, World Intellectual Property Organization, , ,

Production Method 2

259680-39-2

944902-88-9

Reaction Conditions

1.1 Reagents: Chlorotrimethylsilane Solvents: Dichloromethane ;  15 min, cooled
1.2 Reagents: Benzyltriethylammonium chloride ,  tert-Butyl nitrite ;  20 min, cooled; rt; 2 h, rt

Reference

Preparation of novel fused pyrimidine derivatives as selective inhibitors of Toll-like receptors (TLR)

, World Intellectual Property Organization, , ,

Production Method 3

1478126-83-8

944902-88-9

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  Phosphorus oxychloride ;  16 h, 80 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  7 °C

Reference

Discovery and Optimization of Glucose Uptake Inhibitors

Liu, Kevin G. ; Kim, Ji-In; Olszewski, Kellen; Barsotti, Anthony M.; Morris, Koi; et al, Journal of Medicinal Chemistry, 2020, 63(10), 5201-5211

Production Method 4

1478126-83-8

944902-88-9

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  Phosphorus oxychloride ;  16 h, 80 °C
1.2 Reagents: Sodium bicarbonate ;  pH 7

Reference

Preparation of fused pyrimidines as glucose uptake inhibitors

, World Intellectual Property Organization, , ,

Production Method 5

1478126-83-8

944902-88-9

Reaction Conditions

1.1 Reagents: Diisopropylethylamine ,  Phosphorus oxychloride ;  overnight, 80 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 7

Reference

Preparation of heterocyclic compounds and uses thereof

, World Intellectual Property Organization, , ,

Production Method 6

1478126-83-8

944902-88-9

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  rt → reflux; 2 h, reflux

Reference

Preparation of fused pyrimidines as inhibitors of p97 complex

, World Intellectual Property Organization, , ,

Production Method 7

1478126-83-8

944902-88-9

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, 120 °C

Reference

Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of non-small cell lung cancer

Wang, Xueyuan; Bai, Enhe; Zhou, Hui; Sha, Sijia; Miao, Hang; et al, Bioorganic & Medicinal Chemistry, 2019, 27(3), 533-544

2,4-dichloro-5H,7H,8H-pyrano[4,3-d]pyrimidine Raw materials

• 4-chloro-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-amine
• 7,8-dihydro-5H-pyrano[4,3-d]pyrimidine-2,4-diol

2,4-dichloro-5H,7H,8H-pyrano[4,3-d]pyrimidine Preparation Products

• 2,4-dichloro-5H,7H,8H-pyrano[4,3-d]pyrimidine (944902-88-9)

• 1. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 2. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
  LarsBanko,AlfredLudwig
• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 4. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 5. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita

• 1263868-77-4(2,4-Dichloro-8-phenyl-7,8-dihydro-5H-pyrano[4,3-D]pyrimidine)
• 1260671-77-9(4-chloro-5H,7H,8H-pyrano[4,3-d]pyrimidine)
• 1699314-71-0(4-chloro-2-(chloromethyl)-5H,7H,8H-pyrano[4,3-d]pyrimidine)
• 1263868-84-3(2,4-Dichloro-8-(4-fluorophenyl)-7,8-dihydro-5H-pyrano[4,3-D]pyrimidine)
• 1429309-52-3(2,4-Dichloro-7-methyl-5,7-dihydrofuro[3,4-d]pyrimidine)
• 916480-92-7(2,4-Dichloro-5-(1,3-dioxolan-2-yl)-6-isopropylpyrimidine)
• 1269461-25-7(2,4-dichloro-5H,6H,8H-pyrano[3,4-d]pyrimidine)
• 1260088-72-9(2,4-dichloro-7,7-dimethyl-5H,7H-furo[3,4-d]pyrimidine)
• 1547048-63-4(4-chloro-2-methyl-5H,7H,8H-pyrano[4,3-d]pyrimidine)
• 848398-41-4(2,4-dichloro-5H,7H-furo[3,4-d]pyrimidine)