Production Method 1

1005171-62-9

944900-06-5

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  -78 °C; 30 min, -78 °C → -20 °C

Reference

Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same and their preparation

, World Intellectual Property Organization, , ,

Production Method 2

39890-95-4

944900-06-5

Reaction Conditions

1.1 Reagents: Butyllithium ,  Diisopropylethylamine Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C

Reference

Discovery of novel chiral diazepines as bombesin receptor subtype-3 (BRS-3) agonists with low brain penetration

Matsufuji, Tetsuyoshi ; Shimada, Kousei; Kobayashi, Shozo; Kawamura, Asuka; Fujimoto, Teppei; et al, Bioorganic & Medicinal Chemistry Letters, 2014, 24(3), 750-755

Production Method 3

917396-39-5

944900-06-5

Reaction Conditions

1.1 Reagents: Pyridinium chlorochromate Solvents: Dichloromethane ;  3 h, rt

Reference

Fluoroisoquinoline substituted thiazole compounds as protein kinase B inhibitors and their preparation, pharmaceutical compositions and use in the treatment of PKB-mediated diseases

, World Intellectual Property Organization, , ,

Production Method 4

386704-06-9

944900-06-5

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene ;  -78 °C; 1 h, -78 °C; -78 °C → 0 °C
1.2 Reagents: Acetic acid Solvents: Water ;  2 h, 0 °C

Reference

Preparation of 7-phenoxychroman carboxylic acid derivatives for treating and preventing immunological diseases

, World Intellectual Property Organization, , ,

Production Method 5

917396-39-5

944900-06-5

Reaction Conditions

1.1 Reagents: Silica ,  Pyridinium chlorochromate Solvents: Dichloromethane ;  4 h, rt

Reference

Pyridyl carboxamide derivative compounds with nematicidal activity

, World Intellectual Property Organization, , ,

2-Chloro-6-(trifluoromethyl)nicotinaldehyde Raw materials

• 2-Chloro-N-methoxy-N-methyl-6-(trifluoromethyl)nicotinamide
• 2-Chloro-6-(trifluoromethyl)pyridin-3-ylmethanol
• 2-Chloro-6-(trifluoromethyl)pyridine
• 2-chloro-6-(trifluoromethyl)pyridine-3-carbonitrile

2-Chloro-6-(trifluoromethyl)nicotinaldehyde Preparation Products

• 2-Chloro-6-(trifluoromethyl)nicotinaldehyde (944900-06-5)

• 1. An intermolecular C–H oxidizing strategy to access highly fused carbazole skeletons from simple naphthylamines?
  Christian K. Rank,Alexander W. Jones,Tatjana Wall,Patrick Di Martino-Fumo,Sarah Schr?ck,Markus Gerhards,Frederic W. Patureau Chem. Commun., 2019,55, 13749-13752
• 2. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 3. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 4. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 5. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

• 1186306-84-2(2-chloro-6-(trifluoromethyl)pyridine-3-carbonyl chloride)
• 386704-05-8(2-chloro-6-(trifluoromethyl)pyridine-3-carboxamide)
• 91591-73-0(3-PYRIDINECARBOXALDEHYDE, 2-CHLORO-6-METHYL-4-(TRIFLUOROMETHYL)-)
• 1060807-47-7(2-Chloro-6-(trifluoromethyl)pyridine-4-carbaldehyde)
• 280566-45-2(2-chloro-6-(trifluoromethyl)pyridine-3-carboxylic acid)
• 1807152-09-5(2-Chloro-3-(difluoromethyl)-6-(trifluoromethyl)pyridine-5-carboxaldehyde)
• 945971-02-8(2-Chloro-3-methyl-6-(trifluoromethyl)pyridine)
• 944900-15-6(1-(2-Chloro-6-trifluoromethyl-pyridin-3-yl)-ethanone)
• 1804661-81-1(4-(Bromomethyl)-2-chloro-6-(difluoromethyl)pyridine-3-carboxaldehyde)
• 1227581-44-3(6-chloro-2-(trifluoromethyl)pyridine-3-carbaldehyde)