Production Method 1

1196-69-6

944893-74-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Tetrabutylammonium hydrogen sulfate Solvents: Dichloromethane ;  1 h, rt
1.2 3 d, 50 °C

Reference

Substitution at the indole 3 position yields highly potent indole combretastatins against human tumor cells

Alvarez, Raquel; Gajate, Consuelo; Puebla, Pilar; Mollinedo, Faustino; Medarde, Manuel; et al, European Journal of Medicinal Chemistry, 2018, 158, 167-183

Production Method 2

1196-69-6

944893-74-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ;  reflux

Reference

Synthesis of 3,5-diaryl substituted indole derivatives and its selective iodide ion chemosensing

Rathikrishnan, Krishnaswamy R.; Indirapriyadharshini, Vellore K.; Ramakrishna, Seeram; Murugan, Rajendiran, Spectrochimica Acta, 2012, 86, 640-644

Production Method 3

1196-69-6

944893-74-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  10 min, rt
1.2 rt → 35 °C; 18 h, 35 °C

Reference

Pyrazolylquinolinone compounds and compositions for the treatment of tumors and their preparation

, World Intellectual Property Organization, , ,

Production Method 4

1196-69-6

944893-74-7

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  10 min, rt
1.2 rt → 35 °C; 18 h, 35 °C

Reference

Synthetic Lethality in Pancreatic Cancer: Discovery of a New RAD51-BRCA2 Small Molecule Disruptor That Inhibits Homologous Recombination and Synergizes with Olaparib

Bagnolini, Greta; Milano, Domenico; Manerba, Marcella; Schipani, Fabrizio; Ortega, Jose Antonio; et al, Journal of Medicinal Chemistry, 2020, 63(5), 2588-2619

Production Method 5

944893-74-7

Reaction Conditions

Reference

Synthesis of Podophyllotoxin Derivatives as Potential Antitumor Agents

Sun, Yanjun; Chen, Hong; Hua, Huiming; Liu, Yongfeng; Zhang, Shi, Chemistry of Natural Compounds, 2014, 50(3), 408-413

1-Ethyl-1H-indole-5-carbaldehyde Raw materials

• 1H-indole-5-carbaldehyde

1-Ethyl-1H-indole-5-carbaldehyde Preparation Products

• 1-Ethyl-1H-indole-5-carbaldehyde (944893-74-7)

• 1. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 2. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 3. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 4. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives N-alkylindoles

• 7570-45-8(9-Ethyl-9H-carbazole-3-carbaldehyde)
• 119607-53-3(9H-Carbazole-3-carboxaldehyde, 9-propyl-)
• 200698-05-1(9-Benzylcarbazole-3,6-dicarboxaldehyde)
• 854778-47-5(1-Ethyl-1H-indole-6-carbaldehyde)
• 63263-88-7(1-benzyl-1H-indole-5-carbaldehyde)
• 192997-34-5(1-Benzyl-1H-indole-6-carbaldehyde)
• 54117-37-2(9-Benzyl-9H-carbazole-3-carbaldehyde)
• 88107-75-9(9H-Carbazole-3-carboxaldehyde, 9-(1-methylethyl)-)
• 894852-86-9(1-Ethyl-1H-indole-4-carbaldehyde)
• 70207-46-4(DFEC)