Production Method 1

13534-89-9

411235-57-9

944718-27-8

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: Acetonitrile ,  Water ;  5 d, 80 °C

Reference

Hydantoin derivatives for the treatment of inflammatory disorders and their preparation

, World Intellectual Property Organization, , ,

Production Method 2

13534-89-9

411235-57-9

944718-27-8

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ;  2 h, 95 °C

Reference

Preparation of pyridopyrimidines and related heteroaryl compounds as mutant KRAS inhibitors for the treatment of cancers

, World Intellectual Property Organization, , ,

Production Method 3

13534-89-9

126403-68-7

944718-27-8

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ;  rt; 1 h, 65 °C
1.2 Reagents: Potassium carbonate Solvents: Water ;  neutralized

Reference

Preparation of substituted tricyclic 1,4-benzodiazepinone derivatives as allosteric modulators of group II metabotropic glutamate receptors

, World Intellectual Property Organization, , ,

Production Method 4

13534-89-9

411235-57-9

944718-27-8

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Catalysts: Tricyclohexylphosphine ,  Palladium diacetate ;  100 °C

Reference

Preparation of heteroaromatic compounds and their use as dopamine D1 ligands for therapy

, World Intellectual Property Organization, , ,

Production Method 5

1417519-28-8

944718-27-8

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Bromine ,  Hydrogen bromide Solvents: Water ;  -10 °C; < -10 °C; 18 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 11 - 12, rt

Reference

Preparation of purine derivatives for use as antitumor agents

, World Intellectual Property Organization, , ,

Production Method 6

13534-89-9

126403-68-7

944718-27-8

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ;  4 h, 70 °C

Reference

Preparation of tetrahydro-1,8-naphthyridine compounds as ανβ6 integrin inhibitors and therapeutic uses thereof

, World Intellectual Property Organization, , ,

Production Method 7

13534-89-9

126403-68-7

944718-27-8

Reaction Conditions

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ;  2 h, 65 °C

Reference

Preparation of gem-disubstituted piperidine MC2R antagonists useful in the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 8

944718-27-8

Reaction Conditions

Reference

Preparation of 2-(1,2,3,4-tetrahydro-1,8-naphthyridine-linked pyrrolidin-1-yl)-2-phenylacetic acid derivatives as αvβ6 integrin inhibitors

, European Patent Organization, , ,

3-bromo-2-cyclopropyl-pyridine Raw materials

• 2,3-Dibromopyridine
• Cyclopropylboronic acid
• 2-Cyclopropylpyridin-3-amine
• Cyclopropylzinc bromide, 0.50 M in THF

3-bromo-2-cyclopropyl-pyridine Preparation Products

• 3-bromo-2-cyclopropyl-pyridine (944718-27-8)

• 1. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 2. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 3. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 4. An atlas of endohedral Sc2S cluster fullerenes?
  Li-Hua Gan,Rui Wu,Jian-Lei Tian,Patrick W. Fowler Phys. Chem. Chem. Phys., 2017,19, 419-425
• 5. An atomic scale study of defects in Co2FeAl
  Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886

• 94015-49-3(Pyridine, 3,5-dibromo-2,6-dipropyl-)
• 1643564-90-2(3-Bromo-6-(sec-butyl-d9)-pyridine)
• 1417518-37-6(3-Bromo-2-isopropylpyridine)
• 1417518-98-9(3-Bromo-2-cyclobutylpyridine)
• 1417518-07-0(3-BROMO-2-(TERT-BUTYL)PYRIDINE)
• 2228990-95-0(3-(3-bromopyridin-2-yl)-3-methylbutan-1-amine)
• 1951411-48-5(3-Bromo-6-cyclopropyl-2-methylpyridine)
• 1513963-20-6(3-Bromo-2-isobutylpyridine)
• 579475-29-9(5-Bromo-2-cyclopropylpyridine)
• 2228447-25-2(3-(3-Bromopyridin-2-yl)butan-1-amine)