Production Method 1

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; 0.5 h, rt
1.2 Reagents: Sodium thiosulfate Solvents: Water

Reference

High selectivity substituted pyrimidine PI3K inhibitor

, World Intellectual Property Organization, , ,

Production Method 2

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  0 °C; 0 °C → rt; 2 h, rt

Reference

Design, Synthesis, and Biological Evaluation of Novel Imidazo[1,2-a]pyridine Derivatives as Potent c-Met Inhibitors

Li, Chunpu; Ai, Jing; Zhang, Dengyou; Peng, Xia; Chen, Xi; et al, ACS Medicinal Chemistry Letters, 2015, 6(5), 507-512

Production Method 3

944401-72-3

Reaction Conditions

Reference

Pyrazole derivatives as YAP/TAZ-TEAD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer and fibrosis

, World Intellectual Property Organization, , ,

Production Method 4

944401-72-3

Reaction Conditions

Reference

Method of inhibiting hamartoma tumor cells

, United States, , ,

Production Method 5

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile

Reference

Imidazo[1,2-a]pyridine compounds as tyrosine kinase c-Met signal transduction pathway inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cell hyperplasia diseases

, World Intellectual Property Organization, , ,

Production Method 6

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Dimethylformamide ;  rt → -18 °C; 1 h, -18 °C

Reference

Imidazopyridine compounds useful in the treatment of non-insulin dependent diabetes mellitus and their preparation, pharmaceutical compositions

, World Intellectual Property Organization, , ,

Production Method 7

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  3 h, 80 °C

Reference

Preparation of nitrogen-containing macrocyclic compounds useful as BRD4 inhibitors for the treatment of inflammatory disease, cancer, and autoimmune disease

, World Intellectual Property Organization, , ,

Production Method 8

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  2 h, rt
1.2 Reagents: Sodium thiosulfate Solvents: Water ;  rt

Reference

Preparation of substituted pyrrolopyridinones as HPK1 antagonists and uses thereof

, World Intellectual Property Organization, , ,

Production Method 9

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: p-Toluenesulfonic acid ,  Butylpyridinium bromide ,  Hydrogen peroxide Solvents: 1,2-Dimethoxyethane ;  24 h, 80 °C

Reference

A mild method for the regioselective bromination of 2-aminopyridines

Xu, Tong; Zhou, Wen; Wang, Jing; Li, Xue; Guo, Jun-Wen; et al, Tetrahedron Letters, 2014, 55(36), 5058-5061

Production Method 10

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  90 min, rt

Reference

Preparation of dimorpholinopyrimidines for inhibiting hamartoma tumor cells

, World Intellectual Property Organization, , ,

Production Method 11

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  90 min, rt

Reference

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer

Burger, Matthew T.; Pecchi, Sabina; Wagman, Allan; Ni, Zhi-Jie; Knapp, Mark; et al, ACS Medicinal Chemistry Letters, 2011, 2(10), 774-779

Production Method 12

42182-27-4

944401-72-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  90 min, rt

Reference

Pyrimidine derivatives used as PI-3 kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer

, World Intellectual Property Organization, , ,

2-Amino-5-bromoisonicotinonitrile Raw materials

• 2-aminopyridine-4-carbonitrile

2-Amino-5-bromoisonicotinonitrile Preparation Products

• 2-Amino-5-bromoisonicotinonitrile (944401-72-3)

• 1. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 4. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 5. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Aminopyridines and derivatives

• 180994-87-0(2-amino-5-bromo-4-methylpyridine-3-carbonitrile)
• 3430-29-3(3,5-dibromo-4-methyl-pyridin-2-amine)
• 98198-48-2(2-Amino-5-bromo-4-methylpyridine)
• 40073-38-9(3-bromo-4-methylpyridin-2-amine)
• 1029128-27-5(5-Bromo-4-phenylpyridin-2-amine)
• 1227607-07-9(2-Amino-5-bromo-4-(bromomethyl)pyridine)
• 1356109-66-4(5-Bromo-2-(dimethylamino)isonicotinonitrile)
• 1368352-40-2(2-Amino-5-bromo-4-ethylpyridine)
• 1227591-50-5(2-Amino-5-bromopyridine-4-acetonitrile)
• 1805556-80-2(2-Amino-3-bromoisonicotinonitrile)