Production Method 1

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ;  4 h, reflux

Reference

Copper-Catalyzed One-Pot Synthesis of Dibenzofurans, Xanthenes, and Xanthones from Cyclic Diphenyl Iodoniums

Zhu, Daqian ; Li, Min; Wu, Zhouming; Du, Yongliang; Luo, Bingling; et al, European Journal of Organic Chemistry, 2019, 2019(28), 4566-4571

Production Method 2

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: Benzoyl peroxide ,  N-Bromosuccinimide Solvents: Carbon tetrachloride ;  1.5 h, reflux; reflux → rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

The synthesis of (-)-varitriol and (-)-3'-epi-varitriol via a Ramberg-Baecklund route

McAllister, Graeme D.; Robinson, James E.; Taylor, Richard J. K., Tetrahedron, 2007, 63(49), 12123-12130

Production Method 3

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: Azobisisobutyronitrile ,  N-Bromosuccinimide Solvents: Acetonitrile

Reference

Isosteric analogs of lenalidomide and pomalidomide: Synthesis and biological activity

Ruchelman, Alexander L.; Man, Hon-Wah; Zhang, Weihong; Chen, Roger; Capone, Lori; et al, Bioorganic & Medicinal Chemistry Letters, 2013, 23(1), 360-365

Production Method 4

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: Azobisisobutyronitrile ,  N-Bromosuccinimide Solvents: Carbon tetrachloride ;  72 °C; 3 h, reflux

Reference

Metabolically Stable Dibenzo[b,e]oxepin-11(6H)-ones as Highly Selective p38 MAP Kinase Inhibitors: Optimizing Anti-Cytokine Activity in Human Whole Blood

Baur, Benjamin; Storch, Kirsten; Martz, Kathrin E.; Goettert, Marcia I.; Richters, Andre; et al, Journal of Medicinal Chemistry, 2013, 56(21), 8561-8578

Production Method 5

943595-13-9

Reaction Conditions

Reference

Treating long QT syndrome

, World Intellectual Property Organization, , ,

Production Method 6

943595-13-9

Reaction Conditions

Reference

Radical-mediated synthesis of 3,4-dihydroisocoumarins. Total synthesis of hydrangenol. [Erratum to document cited in CA147:143153]

Mandal, Samir Kumar; Roy, Subhas Chandra, Tetrahedron Letters, 2007, 48(35),

Production Method 7

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Carbon tetrachloride ;  reflux
1.2 Catalysts: Azobisisobutyronitrile ;  2 h, reflux; reflux → rt

Reference

Titanocene(III) chloride mediated radical-induced synthesis of 3,4-dihydroisocoumarins: synthesis of (±)-hydrangenol, (±)-phyllodulcin, (±)-macrophyllol and (±)-thunberginol G

Mandal, Samir Kumar; Roy, Subhas Chandra, Tetrahedron, 2008, 64(49), 11050-11057

Production Method 8

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: Azobisisobutyronitrile ,  N-Bromosuccinimide Solvents: Carbon tetrachloride

Reference

Radical-mediated synthesis of 3,4-dihydroisocoumarins. Total synthesis of hydrangenol

Mandal, Samir Kumar; Roy, Subhas Chandra, Tetrahedron Letters, 2007, 48(23), 4131-4134

Production Method 9

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ;  15 min, 25 °C; 12 h, 60 °C

Reference

Compounds modulating protein recruitment and/or degradation

, World Intellectual Property Organization, , ,

Production Method 10

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ;  6 h, rt → reflux

Reference

Histone acetyltransferase activators and compositions and uses thereof

, World Intellectual Property Organization, , ,

Production Method 11

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ;  6 h, reflux

Reference

Preparation of isoindolinone and benzamide derivatives as histone acetyltransferase activators useful in disease therapy

, World Intellectual Property Organization, , ,

Production Method 12

79383-44-1

943595-13-9

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ;  2 h, reflux

Reference

Assessment of the regioselectivity in the condensation reaction of unsymmetrical o-phthaldialdehydes with alanine

D'Hollander, Agathe C. A.; Westwood, Nicholas J., Tetrahedron, 2018, 74(2), 224-239

Production Method 13

6161-65-5

943595-13-9

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  3 h, 80 °C
1.2 cooled; 30 min, 80 °C
1.3 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ;  overnight, reflux

Reference

Preparation of isoindole carboxamides, pyrrolopyridine carboxamides, and similar compounds as inhibitors of phosphodiesterase type 10A for treating neurological and psychiatric disorders

, World Intellectual Property Organization, , ,

2-Bromomethyl-6-methoxy-benzoic Acid Methyl Ester Raw materials

• 2-Methoxy-6-methylbenzoic acid
• Methyl 2-methoxy-6-methylbenzoate

2-Bromomethyl-6-methoxy-benzoic Acid Methyl Ester Preparation Products

• 2-Bromomethyl-6-methoxy-benzoic Acid Methyl Ester (943595-13-9)

• 1. Dissolved oxygen sensor based on fluorescence quenching of oxygen-sensitive ruthenium complexes immobilized in sol–gel-derived porous silica coatings
  Analyst, 1996,121, 785-788
• 2. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 3. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 4. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 5. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161

• 19722-76-0(Methyl 2,6-dihydroxy-4-methoxybenzoate)
• 2150-41-6(Methyl 2,4-dimethoxybenzoate)
• 74292-74-3(Methyl 2-(benzyloxy)-6-hydroxybenzoate)
• 89877-54-3(Benzoic acid, 2-hydroxy-4,6-dimethoxy-3-methyl-, methyl ester)
• 5446-02-6(Methyl 4-methoxysalicylate)
• 51116-92-8(Methyl 4,6-Dimethoxysalicylate)
• 28478-46-8(Methyl 4-hydroxy-2-methoxybenzoate)
• 2065-27-2(Methyl 2,6-dimethoxybenzoate)
• 29723-28-2(Methyl 2,4,6-trimethoxybenzoate)
• 5427-29-2(2-Hydroxy-4-(phenylmethoxy)benzoic Acid Methyl Ester)