- Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors useful in the treatment of diseases, European Patent Organization, , ,
Cas no 943153-22-8 ((5-chloro-2-methoxypyridin-3-yl)boronic acid)
(5-Chloro-2-methoxypyridin-3-yl)boronic acid is a versatile boronic acid derivative widely used as a key intermediate in Suzuki-Miyaura cross-coupling reactions. Its pyridine scaffold, coupled with the chloro and methoxy substituents, enhances its reactivity and selectivity in forming carbon-carbon bonds, making it valuable in pharmaceutical and agrochemical synthesis. The boronic acid group facilitates efficient coupling with aryl or vinyl halides under mild conditions, while the electron-donating methoxy group stabilizes the intermediate complex. This compound exhibits good solubility in common organic solvents, ensuring compatibility with diverse reaction conditions. Its high purity and stability under inert atmospheres further contribute to its reliability in synthetic applications.
943153-22-8 structure
Product Name:(5-chloro-2-methoxypyridin-3-yl)boronic acid
CAS No:943153-22-8
MF:C6H7BClNO3
MW:187.388680696487
MDL:MFCD04114579
CID:796849
PubChem ID:44754881
Update Time:2025-05-27
(5-chloro-2-methoxypyridin-3-yl)boronic acid Chemical and Physical Properties
Names and Identifiers
-
- 5-Chloro-2-methoxypyridine-3-boronic acid
- 5-chloro-2-methoxypyridin-3-ylboronic acid
- (5-Chloro-2-methoxypyridin-3-yl)boronic acid
- 5-Chloro-2-methoxy-pyridine-3-boronic acid
- Boronic acid, B-(5-chloro-2-methoxy-3-pyridinyl)-
- B-(5-Chloro-2-methoxy-3-pyridinyl)boronic acid (ACI)
- 943153-22-8
- AC-33496
- AMY8022
- SY066583
- J-517319
- CS-0042538
- AS-55769
- 5-Chloro-2-methoxypyridine-3-boronicacid
- EN300-212558
- 5-chloro-2-methoxypyridin-3-yl-3-boronic acid
- SCHEMBL321726
- AKOS006295154
- DTXSID20660569
- BZJQXIUWWLFBJS-UHFFFAOYSA-N
- MFCD04114579
- Z1198164292
- AB18596
- (5-chloro-2-methoxypyridin-3-yl)boronic acid
-
- MDL： MFCD04114579
- Inchi： 1S/C6H7BClNO3/c1-12-6-5(7(10)11)2-4(8)3-9-6/h2-3,10-11H,1H3
- InChI Key： BZJQXIUWWLFBJS-UHFFFAOYSA-N
- SMILES： ClC1=CN=C(C(B(O)O)=C1)OC
Computed Properties
- Exact Mass: 187.02100
- Monoisotopic Mass: 187.021
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 12
- Rotatable Bond Count: 2
- Complexity: 149
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 62.6A^2
Experimental Properties
- Density: 1.4
- Melting Point: 148-152°C
- Boiling Point: 353.1 ℃ at 760 mmHg
- Flash Point: 167.3 ℃
- Refractive Index: 1.545
- PSA: 62.58000
- LogP: -0.57660
(5-chloro-2-methoxypyridin-3-yl)boronic acid Customs Data
- HS CODE：2933399090
- Customs Data：
China Customs Code:
2933399090Overview:
2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
(5-chloro-2-methoxypyridin-3-yl)boronic acid Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 32R0033-1g |
5-Chloro-2-methoxy-pyridine-3-boronic acid |
943153-22-8 | 97% | 1g |
1229.66CNY | 2021-05-07 | |
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 32R0033-5g |
5-Chloro-2-methoxy-pyridine-3-boronic acid |
943153-22-8 | 97% | 5g |
3646.58CNY | 2021-05-07 | |
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 32R0033-25g |
5-Chloro-2-methoxy-pyridine-3-boronic acid |
943153-22-8 | 97% | 25g |
10176.51CNY | 2021-05-07 | |
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 32R0033-500mg |
5-Chloro-2-methoxy-pyridine-3-boronic acid |
943153-22-8 | 97% | 500mg |
1060.05CNY | 2021-05-07 | |
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 32R0033-250mg |
5-Chloro-2-methoxy-pyridine-3-boronic acid |
943153-22-8 | 97% | 250mg |
924.37CNY | 2021-05-07 | |
| JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd. | 32R0033-100mg |
5-Chloro-2-methoxy-pyridine-3-boronic acid |
943153-22-8 | 97% | 100mg |
805.64CNY | 2021-05-07 | |
| Chemenu | CM100087-10g |
5-chloro-2-methoxypyridin-3-yl-3-boronic acid |
943153-22-8 | 0.95 | 10g |
$450 | 2021-08-06 | |
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | C824881-1g |
5-chloro-2-methoxypyridin-3-yl-3-boronic acid |
943153-22-8 | ≥95% | 1g |
￥397.80 | 2022-09-02 | |
| Ambeed | A134667-250mg |
(5-Chloro-2-methoxypyridin-3-yl)boronic acid |
943153-22-8 | 98% | 250mg |
$33.0 | 2025-04-15 | |
| Ambeed | A134667-1g |
(5-Chloro-2-methoxypyridin-3-yl)boronic acid |
943153-22-8 | 98% | 1g |
$40.0 | 2025-04-15 |
(5-chloro-2-methoxypyridin-3-yl)boronic acid Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Butyllithium , Triisopropyl borate Solvents: Tetrahydrofuran , Hexane ; 2 h, -100 °C; -100 °C → rt; overnight, rt; rt → 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 1 h, 0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 6
1.2 Reagents: Hydrochloric acid Solvents: Water ; 1 h, 0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 6
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Butyllithium , Triisopropyl borate Solvents: Tetrahydrofuran , Hexane ; -100 °C; 2 h, -100 °C; overnight, -100 °C → rt; rt → 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 0 °C; 1 h, 0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 6
1.2 Reagents: Hydrochloric acid Solvents: Water ; 0 °C; 1 h, 0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 6
Reference
- Imidazo[1,2-b]pyridazine and imidazo[4,5-b]pyridine derivatives as JAK inhibitors useful in the treatment of diseases, World Intellectual Property Organization, , ,
(5-chloro-2-methoxypyridin-3-yl)boronic acid Raw materials
(5-chloro-2-methoxypyridin-3-yl)boronic acid Preparation Products
(5-chloro-2-methoxypyridin-3-yl)boronic acid Related Literature
-
Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
-
Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
-
Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
-
Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
-
Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
943153-22-8 ((5-chloro-2-methoxypyridin-3-yl)boronic acid) Related Products
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