Production Method 1

105806-13-1

943006-45-9

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Methanol ,  Water ;  2 h, 70 °C

Reference

Structure-Based Design of a Novel Series of Potent, Selective Inhibitors of the Class I Phosphatidylinositol 3-Kinases

Smith, Adrian L.; D'Angelo, Noel D.; Bo, Yunxin Y.; Booker, Shon K.; Cee, Victor J.; et al, Journal of Medicinal Chemistry, 2012, 55(11), 5188-5219

Production Method 2

675-21-8

943006-45-9

Reaction Conditions

1.1 Solvents: Methanol ;  120 - 150 °C

Reference

Process for synthesizing 2-methyl-5-fluoro-4-amino-6-chloropyrimidine as medical raw material

, China, , ,

Production Method 3

105806-13-1

943006-45-9

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Methanol ,  Water ;  2 h, 70 °C
1.2 Reagents: Water ;  30 min, cooled

Reference

Preparation of heteroaryl compounds as PIKK inhibitors for the treatment of cancer

, World Intellectual Property Organization, , ,

Production Method 4

105806-13-1

943006-45-9

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Methanol ,  Water ;  2 h, 70 °C
1.2 Solvents: Water ;  30 min, cooled

Reference

Preparation of 3-azaheterocyclyl-N-(substituted monocyclyl or bicyclyl)pyridine-2-amines and analogs as PI3 kinase and/or mTOR inhibitors for treating cancers

, United States, , ,

Production Method 5

105806-13-1

943006-45-9

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Methanol ;  2 h, 70 °C; 70 °C → rt

Reference

Preparation of thiazoles as calcium channel antagonists

, World Intellectual Property Organization, , ,

Production Method 6

105806-13-1

943006-45-9

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Methanol ,  Water ;  2 h, 70 °C

Reference

Preparation of [5-(3-ethoxybenzenesulfonyl)thiazol-2-yl]amine derivatives as calcium channel antagonists

, World Intellectual Property Organization, , ,

6-Chloro-5-fluoro-2-methylpyrimidin-4-amine Raw materials

• 4,6-Dichloro-5-fluoro-2-methylpyrimidine
• 5-Fluoropyrimidine

6-Chloro-5-fluoro-2-methylpyrimidin-4-amine Preparation Products

• 6-Chloro-5-fluoro-2-methylpyrimidin-4-amine (943006-45-9)

• 1. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 3. Emergence of microfluidic wearable technologies
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• 4. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

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• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)