Production Method 1

88-65-3

943-14-6

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  cooled; 1 h, < 5 °C

Reference

Donor-acceptor biaryl lactones: pH induced molecular switches with intramolecular charge transfer modulation

Carlson, Erik J.; Riel, Asia Marie S.; Dahl, Bart J., Tetrahedron Letters, 2012, 53(46), 6245-6249

Production Method 2

88-65-3

943-14-6

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  < 5 °C; 1 h, < 5 °C
1.2 Reagents: Water ;  cooled

Reference

Preparation of pyrrolidinylchromenones as inhibitors of cyclin-dependent kinases

, United States, , ,

Production Method 3

943-14-6

Reaction Conditions

Reference

Benzamide derivatives with pharmacological properties

, Spain, , ,

Production Method 4

88-65-3

943-14-6

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  < 5 °C; 1 h, < 5 °C

Reference

Preparation of pyrrolidinylchromenones as inhibitors of cyclin-dependent kinases.

, World Intellectual Property Organization, , ,

Production Method 5

943-14-6

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Permanganic acid (HMnO4), potassium salt (1:1)

Reference

Synthesis of lysergic acid. I. Derivatives of indole

Barltrop, J. A.; Taylor, D. A. H., Journal of the Chemical Society, 1954, 3399, 3399-3403

Production Method 6

121-92-6

943-14-6

Reaction Conditions

1.1 Reagents: Bromine ,  Potassium bromide

Reference

Syntheses of naphthoic mercury compounds and their reaction with nucleophilic reagents

Takahashi, Teruo, Yakugaku Zasshi, 1978, 98(3), 358-65

Production Method 7

84459-32-5

943-14-6

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  Permanganic acid (HMnO4), potassium salt (1:1) Solvents: Water ;  overnight, rt

Reference

Tandem copper catalyzed regioselective N-arylation-amidation: synthesis of angularly fused dihydroimidazoquinazolinones and the anticancer agent TIC10/ONC201

Honnanayakanavar, Jyoti M.; Nanubolu, Jagadeesh Babu; Suresh, Surisetti, Organic & Biomolecular Chemistry, 2021, 19(39), 8497-8501

Production Method 8

943-14-6

Reaction Conditions

Reference

The discovery of novel small molecule allosteric activators of aldehyde dehydrogenase 2

Tian, Wei; Guo, Jiapeng; Zhang, Qingsen; Fang, Shaoyu; Zhou, Ruolan; et al, European Journal of Medicinal Chemistry, 2021, 212,

Production Method 9

943-14-6

Reaction Conditions

Reference

Method for preparing 5-amino-2-bromobenzoic acid

, China, , ,

2-Bromo-5-nitrobenzoic acid Raw materials

• 2-Bromobenzoic acid
• 2-Bromo-5-nitrobenzaldehyde
• 3-Nitrobenzoic acid

2-Bromo-5-nitrobenzoic acid Preparation Products

• 2-Bromo-5-nitrobenzoic acid (943-14-6)

• 1. Exclusive self-aligned β-phase PVDF films with abnormal piezoelectric coefficient prepared via phase inversion?
  N. Soin,D. Boyer,K. Prashanthi,S. Sharma,A. A. Narasimulu,J. Luo,T. H. Shah,E. Siores,T. Thundat Chem. Commun., 2015,51, 8257-8260
• 2. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 4. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 5. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962

• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Introduction to 2-Bromo-5-nitrobenzoic acid (CAS No. 943-14-6)

2-Bromo-5-nitrobenzoic acid (CAS No. 943-14-6) is a versatile organic compound with significant applications in various fields, including pharmaceuticals, chemical synthesis, and materials science. This compound is characterized by its unique molecular structure, which includes a bromine atom and a nitro group attached to a benzoic acid backbone. These functional groups contribute to its reactivity and potential utility in a wide range of chemical reactions and biological processes.

The molecular formula of 2-Bromo-5-nitrobenzoic acid is C₇H₄BrNO₄, and its molecular weight is approximately 237.01 g/mol. The compound is a white to off-white crystalline solid at room temperature and is soluble in polar solvents such as water, methanol, and dimethyl sulfoxide (DMSO). Its physical and chemical properties make it an attractive candidate for various synthetic transformations and as a building block in the development of new materials and pharmaceuticals.

In the realm of pharmaceutical research, 2-Bromo-5-nitrobenzoic acid has garnered attention due to its potential as an intermediate in the synthesis of bioactive compounds. Recent studies have explored its use in the development of novel drugs targeting specific biological pathways. For instance, researchers have investigated the compound's ability to modulate enzyme activity and its potential as an inhibitor of certain enzymes involved in disease processes.

A study published in the Journal of Medicinal Chemistry highlighted the use of 2-Bromo-5-nitrobenzoic acid as a key intermediate in the synthesis of a series of novel anti-inflammatory agents. The compounds derived from this intermediate showed promising activity in reducing inflammation in vitro and in animal models. This research underscores the importance of 2-Bromo-5-nitrobenzoic acid as a valuable starting material for the development of new therapeutic agents.

Beyond pharmaceutical applications, 2-Bromo-5-nitrobenzoic acid has also found utility in materials science. Its unique electronic properties make it suitable for use in the synthesis of conductive polymers and other advanced materials. Researchers have explored its role in the development of organic semiconductors, which have potential applications in electronic devices such as organic light-emitting diodes (OLEDs) and solar cells.

In the context of chemical synthesis, 2-Bromo-5-nitrobenzoic acid serves as a versatile building block for constructing complex molecules. Its reactivity with various functional groups allows chemists to introduce multiple substituents at specific positions on the aromatic ring, leading to a wide array of structurally diverse compounds. This versatility has made it a popular choice for synthetic chemists working on the development of new materials and pharmaceuticals.

The safety profile of 2-Bromo-5-nitrobenzoic acid is an important consideration for its use in research and industrial applications. While it is generally considered safe when handled properly, standard laboratory safety protocols should be followed to minimize any potential risks. Proper storage conditions, such as keeping the compound away from heat sources and incompatible materials, are essential to ensure its stability and prevent any unintended reactions.

In conclusion, 2-Bromo-5-nitrobenzoic acid (CAS No. 943-14-6) is a multifaceted compound with significant potential across various scientific disciplines. Its unique molecular structure and reactivity make it an invaluable tool for researchers working on new drug development, materials science, and chemical synthesis. As ongoing research continues to uncover new applications and properties, the importance of this compound is likely to grow further.

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