- Preparation of fused heterocyclic compound and application thereof, China, , ,
Cas no 942920-50-5 (4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine)
![4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine structure](https://ossimg.kuujia.com/scimg/943000/942920-50-5x500.png)
942920-50-5 structure
Product Name:4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine
CAS No:942920-50-5
MF:C7H4BrClN2
MW:231.477059364319
MDL:MFCD09880158
CID:821326
PubChem ID:24729595
Update Time:2024-10-25
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine Chemical and Physical Properties
Names and Identifiers
-
- 4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine
- 1H-Pyrrolo[2,3- b]pyridine, 4-bromo-6-chloro-
- 4-Bromo-6-chloro-7-azaindole
- 1H-PYRROLO[2,3-B]PYRIDINE, 4-BROMO-6-CHLORO-
- PubChem19351
- OATRMIWUNLJMJV-UHFFFAOYSA-N
- VP12406
- PB10765
- FCH1394924
- BC004437
- ST1090510
- AX8165441
- AB0038311
- Y5671
- A844904
- 920P505
- 4-bromanyl-6-chloranyl-1H-pyrrolo[2,3-b]pyridine
- 4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine (ACI)
- AKOS015851080
- CS-0002349
- MFCD09880158
- SCHEMBL4322050
- AS-33556
- SY097977
- 942920-50-5
- DTXSID10646913
-
- MDL： MFCD09880158
- Inchi： 1S/C7H4BrClN2/c8-5-3-6(9)11-7-4(5)1-2-10-7/h1-3H,(H,10,11)
- InChI Key： OATRMIWUNLJMJV-UHFFFAOYSA-N
- SMILES： ClC1C=C(Br)C2=C(NC=C2)N=1
Computed Properties
- Exact Mass: 229.92500
- Monoisotopic Mass: 229.925
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 1
- Heavy Atom Count: 11
- Rotatable Bond Count: 0
- Complexity: 155
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 28.7
- Surface Charge: 0
- Tautomer Count: 2
- XLogP3: 3
Experimental Properties
- Density: 1.878
- Boiling Point: 359.8 °C at 760 mmHg
- Flash Point: 359.8 °C at 760 mmHg
- Refractive Index: 1.73
- PSA: 28.68000
- LogP: 2.97880
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| CHENG DOU FEI BO YI YAO Technology Co., Ltd. | FB06106-5g |
4-bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine |
942920-50-5 | 95% | 5g |
$1400 | 2023-09-07 | |
| Matrix Scientific | 057532-1g |
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine, 95% |
942920-50-5 | 95% | 1g |
$1,277.00 | 2021-06-27 | |
| TRC | B545715-50mg |
4-Bromo-6-chloro-1H-pyrrolo[2,3-B]pyridine |
942920-50-5 | 50mg |
$ 224.00 | 2023-04-18 | ||
| TRC | B545715-250mg |
4-Bromo-6-chloro-1H-pyrrolo[2,3-B]pyridine |
942920-50-5 | 250mg |
$ 994.00 | 2023-04-18 | ||
| TRC | B545715-500mg |
4-Bromo-6-chloro-1H-pyrrolo[2,3-B]pyridine |
942920-50-5 | 500mg |
$ 1200.00 | 2023-09-08 | ||
| Alichem | A029192369-1g |
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine |
942920-50-5 | 95% | 1g |
$459.00 | 2023-08-31 | |
| Chemenu | CM109148-1g |
4-bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine |
942920-50-5 | 95%+ | 1g |
$759 | 2021-08-06 | |
| Chemenu | CM109148-250mg |
4-bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine |
942920-50-5 | 95%+ | 250mg |
$196 | 2024-07-19 | |
| Chemenu | CM109148-1g |
4-bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine |
942920-50-5 | 95%+ | 1g |
$*** | 2023-03-31 | |
| eNovation Chemicals LLC | Y1193505-1g |
4-Bromo-6-chloro-7-azaindole |
942920-50-5 | 95% | 1g |
$400 | 2023-09-03 |
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Methanesulfonyl chloride Solvents: Dimethylformamide ; 1 h, 50 °C → 75 °C
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Methanesulfonyl chloride Solvents: Dimethylformamide ; 50 °C; 2 h, 75 °C; 75 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 7, 0 °C; 3 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; pH 7, 0 °C; 3 h, rt
Reference
- Heterocyclic fused pyrimidine derivative, pharmaceutical composition thereof, and application thereof, World Intellectual Property Organization, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: Methanesulfonyl chloride Solvents: Dimethylformamide ; 50 °C; 1 h, 75 °C; 75 °C → rt
1.2 Reagents: Water ; rt → 5 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 7, 5 °C; 3 h, rt
1.2 Reagents: Water ; rt → 5 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 7, 5 °C; 3 h, rt
Reference
- Preparation of azaindoles as aurora kinase inhibitors for the treatment of cancer, United States, , ,
Production Method 4
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride ; 16 h, 100 °C; 100 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ; 0 °C
Reference
- Preparation of heterocyclic inhibitors of ATR kinase, World Intellectual Property Organization, , ,
Production Method 5
Reaction Conditions
1.1 Reagents: Phosphorus oxychloride ; 16 h, 100 °C; 16 h, 100 °C → rt
1.2 Reagents: Sodium bicarbonate Solvents: Dichloromethane , Water ; rt
1.2 Reagents: Sodium bicarbonate Solvents: Dichloromethane , Water ; rt
Reference
- Preparation of tetrahydropyrido[4,3-d]pyrimidine as ATR kinase inhibitors for treatment of cancer, World Intellectual Property Organization, , ,
Production Method 6
Reaction Conditions
1.1 Reagents: Methanesulfonyl chloride Solvents: Dimethylformamide ; 50 °C; 1 h, 75 °C; 75 °C → rt
1.2 Reagents: Water ; rt → 0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; neutralized, 0 °C
1.2 Reagents: Water ; rt → 0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ; neutralized, 0 °C
Reference
- Preparation of N-(pyrrolopyridinyl) sulfonamides as novel NADPH oxidase II inhibitors, World Intellectual Property Organization, , ,
Production Method 7
Reaction Conditions
Reference
- Preparation of fused heterocyclic compound and application thereof, World Intellectual Property Organization, , ,
Production Method 8
Reaction Conditions
Reference
- Five-membered nitrogen-containing heterocyclic and heteroaryl derivative and application as ATR kinase inhibitor, World Intellectual Property Organization, , ,
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine Raw materials
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine Preparation Products
4-Bromo-6-chloro-1H-pyrrolo[2,3-b]pyridine Related Literature
-
David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474
-
Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
-
Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
-
Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615
-
Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
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