Production Method 1

94250-81-4

94250-82-5

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Methanol ,  Water

Reference

Annulation of α-formyl α,β-unsaturated ketones by a Michael addition-cyclization sequence. A versatile synthesis of alicyclic six-membered rings

Meyer, Walter L.; Brannon, Michael J.; Burgos, Celmira da G.; Goodwin, Thomas E.; Howard, Ralph W., Journal of Organic Chemistry, 1985, 50(4), 438-47

Production Method 2

94250-82-5

Reaction Conditions

Reference

Conformational analysis of the rhodopsin chromophore using 6-s-cis-fixed bicyclic retinal analogs

Wada, Akimori; Ito, Masayoshi, Bitamin, 1997, 71(9), 407-414

Production Method 3

23203-50-1

94250-82-5

Reaction Conditions

1.1 Reagents: Boron tribromide Solvents: Dichloromethane ;  15 min, -78 °C; 30 min, rt
1.2 Reagents: Water ;  rt

Reference

Chiral Anion Phase-Transfer Catalysis Applied to the Direct Enantioselective Fluorinative Dearomatization of Phenols

Phipps, Robert J.; Toste, F. Dean, Journal of the American Chemical Society, 2013, 135(4), 1268-1271

Production Method 4

226547-36-0

226547-37-1

94250-82-5

107054-64-8

Reaction Conditions

1.1 Reagents: Lithium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran ;  2 h, -70 °C
1.2 Reagents: Ammonium chloride Solvents: Water
1.3 Reagents: Azobisisobutyronitrile ,  Tributylstannane Solvents: Toluene ;  10 min, reflux

Reference

An improved synthesis of benzocycloalkanone derivatives

Wada, Akimori; Sawada, Kyoko; Ono, Naomi; Ito, Masayoshi, Chemical & Pharmaceutical Bulletin, 2004, 52(1), 132-135

Production Method 5

60326-61-6

94250-82-5

171979-69-4

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Acetic acid

Reference

Alkylation of phenol with a homoallylic halide

Har, Harold; Corbi, James L.; Wagne, Charles R.; W, Ching-Yong, Journal of the American Chemical Society, 1963, 85(20), 3269-73

Production Method 6

405200-88-6

197460-64-3

94250-82-5

107054-64-8

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: o-Xylene
1.2 Reagents: Ammonium chloride Solvents: Water
1.3 Reagents: Magnesium chloride Solvents: Dimethyl sulfoxide

Reference

Retinoids and related compounds. Part 26. Synthesis of (11Z)-8,18-propano- and methano-retinals and conformational study of the rhodopsin chromophore

Wada, Akimori; Tsutsumi, Masako; Inatomi, Yuka; Imai, Hiroo; Shichida, Yoshinori; et al, Journal of the Chemical Society, 2001, (19), 2430-2439

8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-ol Raw materials

• 4a(2H)-Naphthalenecarboxylic acid, 1,3,4,7-tetrahydro-1,1-dimethyl-7-oxo-, ethyl ester
• Acetic acid, 2-[2,2-dimethyl-6-[2-(phenylsulfonyl)ethyl]cyclohexylidene]-, ethyl ester
• 7-methoxy-1,1-dimethyl-1,2,3,4-tetrahydronaphthalene
• 5,5-dimethyl-3,4-dihydro-2h-1-benzoxepine
• Ethyl 6,6-dimethyl-2-[2-(phenylsulfonyl)ethyl]-1-cyclohexene-1-acetate
• Ethyl (2E)-2-(2-ethoxy-2-oxoethylidene)-3,3-dimethylcyclohexanepropanoate
• Ethyl 2-(2-ethoxy-2-oxoethyl)-3,3-dimethyl-1-cyclohexene-1-propanoate

8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-ol Preparation Products

• 8,8-Dimethyl-1,2,3,4,5,6,7,8-octahydronaphthalene-2-one (107054-64-8)
• 1-Naphthalenol, 5,6,7,8-tetrahydro-5,5-dimethyl- (171979-69-4)
• 8,8-dimethyl-5,6,7,8-tetrahydronaphthalen-2-ol (94250-82-5)

• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 3. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 4. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 5. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431

• Solvents and Organic Chemicals Organic Compounds Benzenoids Tetralins Tetralins
• Solvents and Organic Chemicals Organic Compounds Benzenoids Tetralins

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