• 1. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
  Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
• 2. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 3. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 4. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277
• 5. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidones Oxoprolines

1-3-(Dimethylamino)propyl-5-oxopyrrolidine-3-carboxylic Acid (CAS No. 94108-46-0)

The compound 1-3-(dimethylamino)propyl-5-oxopyrrolidine-3-carboxylic acid, identified by the CAS registry number CAS No. 94108-46-0, is a significant molecule in the field of organic chemistry and pharmaceutical research. This compound belongs to the class of amino acids, specifically featuring a pyrrolidine ring with a carboxylic acid group and a dimethylamino substituent, which imparts unique chemical properties and biological activity.

Recent studies have highlighted the potential of this compound in various applications, particularly in drug discovery and development. The presence of the dimethylamino group enhances its ability to act as a bioisostere, making it a valuable tool in medicinal chemistry for designing new therapeutic agents. Researchers have explored its role in modulating enzyme activity, particularly in kinase inhibitors, where its structural features provide a platform for enhancing potency and selectivity.

The synthesis of 1-3-(dimethylamino)propyl-5-oxopyrrolidine-3-carboxylic acid involves multi-step organic reactions, including alkylation, cyclization, and oxidation processes. These methods have been optimized to achieve high yields and purity, ensuring its suitability for advanced biological assays and preclinical studies. The compound's stability under various reaction conditions has also been extensively studied, contributing to its reliability in laboratory settings.

In terms of biological activity, this compound exhibits promising results in vitro models, particularly in assays targeting neurodegenerative diseases such as Alzheimer's disease. Its ability to cross the blood-brain barrier (BBB) has been validated through pharmacokinetic studies, making it a candidate for central nervous system (CNS) drug development. Additionally, its anti-inflammatory properties have been explored in models of chronic inflammation, suggesting potential applications in autoimmune disorders.

The structural versatility of CAS No. 94108-46-0 allows for further functionalization, enabling researchers to design derivatives with enhanced pharmacokinetic profiles or improved bioavailability. Such modifications are critical in overcoming challenges associated with drug delivery and efficacy, particularly in complex biological systems.

Moreover, computational chemistry techniques have been employed to predict the compound's interactions with target proteins at the molecular level. These studies provide insights into its binding affinity and selectivity, guiding further optimization efforts in drug design.

In conclusion, 1-3-(dimethylamino)propyl-5-oxopyrrolidine-3-carboxylic acid, with its unique chemical structure and promising biological properties, continues to be a focal point in scientific research. As advancements in synthetic methodologies and biological assays unfold, this compound holds the potential to contribute significantly to the development of novel therapeutic agents addressing unmet medical needs.

• 94108-37-9(3-Pyrrolidinecarboxylicacid, 1-decyl-5-oxo-)
• 42346-68-9(1-Methyl-5-oxopyrrolidine-3-carboxylic acid)
• 428518-38-1(3-Pyrrolidinecarboxylicacid, 1-ethyl-5-oxo-, (3S)-)
• 428518-40-5(3-PYRROLIDINECARBOXYLIC ACID, 1-BUTYL-5-OXO-, (3R)-)
• 43094-86-6(1-butyl-5-oxopyrrolidine-3-carboxylic acid)
• 52743-73-4(1-Ethyl-5-oxopyrrolidine-3-carboxylic acid)
• 208118-23-4(5-Oxo-1-propylpyrrolidine-3-carboxylic acid)
• 773865-07-9(1-(2-Methylpropyl)-5-oxopyrrolidine-3-carboxylic Acid)
• 944648-73-1(1-(3-methylbutyl)-5-oxopyrrolidine-3-carboxylic Acid)
• 1245614-91-8(1-Propanoylpyrrolidine-3-carboxylic acid)