Production Method 1

13250-43-6

940-06-7

Reaction Conditions

1.1 Reagents: Silver nitrate Solvents: Water ;  rt → 80 °C; 1 - 2 h, 80 °C

Reference

Reactions of 3-R-5-nitropyridines with nucleophiles: Nucleophilic substitution vs conjugate addition

Bastrakov, Maxim A.; Nikol'skiy, Vladislav V.; Starosotnikov, Alexey M.; Fedyanin, Ivan V.; Shevelev, Svyatoslav A.; et al, Tetrahedron, 2019, 75(47),

Production Method 2

13250-43-6

940-06-7

Reaction Conditions

1.1 Reagents: Silver acetate Solvents: Methanol ,  Water ;  overnight, reflux

Reference

Preparation of 3-(heterocyclylmethoxy)pyridines as nicotinic cholinergic agonists

, United States, , ,

Production Method 3

13250-43-6

940-06-7

Reaction Conditions

1.1 Reagents: Silver acetate Solvents: Methanol ,  Water ;  overnight, reflux

Reference

Preparation of heterocyclic ethers as neuronal nicotinic receptor ligands

, World Intellectual Property Organization, , ,

Production Method 4

940-06-7

Reaction Conditions

1.1 Reagents: Nitrogen dioxide

Reference

Ozone-mediated C-nitration of pyridine and methylpyridines with nitrogen dioxide

Suzuki, Hitomi; Kozai, Iku; Murashima, Takashi, Journal of Chemical Research, 1993, (4), 156-7

Production Method 5

13250-43-6

940-06-7

Reaction Conditions

1.1 Reagents: Acetic acid, silver salt Solvents: Water

Reference

Synthesis of 3,5-dinitropyridine

Plazek, Edwin, Recueil des Travaux Chimiques des Pays-Bas et de la Belgique, 1953, 72, 569-75

Production Method 6

2578-45-2

940-06-7

Reaction Conditions

1.1 Reagents: Hydrazine Solvents: Dichloromethane ;  0 °C; 18 h, rt
1.2 Reagents: Silver nitrate Solvents: Water ;  3 h, reflux; reflux → rt
1.3 Solvents: tert-Butyl methyl ether ;  rt

Reference

3,5-Pyridyne-A Heterocyclic meta-Benzyne Derivative

Winkler, Michael; Cakir, Bayram; Sander, Wolfram, Journal of the American Chemical Society, 2004, 126(19), 6135-6149

Production Method 7

13250-43-6

940-06-7

Reaction Conditions

1.1 Reagents: Silver nitrate Solvents: Water ;  rt; rt → reflux; 5 h, reflux

Reference

Electron-Deficient Heteroarenium Salts: An Organocatalytic Tool for Activation of Hydrogen Peroxide in Oxidations

Sturala, Jiri; Bohacova, Sona; Chudoba, Josef; Metelkova, Radka; Cibulka, Radek, Journal of Organic Chemistry, 2015, 80(5), 2676-2699

Production Method 8

2578-45-2

940-06-7

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Methanol ;  10 min, 0 °C; overnight, rt
1.2 Reagents: Silver acetate Solvents: Water ;  3 h, reflux
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 9, reflux → rt

Reference

Lewis Acidic Boranes, Lewis Bases, and Equilibrium Constants: A Reliable Scaffold for a Quantitative Lewis Acidity/Basicity Scale

Mayer, Robert J. ; Hampel, Nathalie; Ofial, Armin R., Chemistry - A European Journal, 2021, 27(12), 4070-4080

Production Method 9

14080-32-1

940-06-7

Reaction Conditions

Reference

Product class 1: pyridines

Spitzner, D., Science of Synthesis, 2005, 15, 11-284

Production Method 10

940-06-7

Reaction Conditions

Reference

Thermal Decomposition Pathways of 1,3,3-Trinitroazetidine (TNAZ), Related 3,3-Dinitroazetidium Salts, and 15N, 13C, and 2H Isotopomers

Oxley, Jimmie; Smith, James; Zheng, Weiyi; Rogers, Evan; Coburn, Michael, Journal of Physical Chemistry A, 1997, 101(24), 4375-4383

Production Method 11

940-06-7

Reaction Conditions

Reference

Preparation of 2-(3-pyridyloxyalkyl)azetidines and -pyrrolidines as nicotinic receptor ligands

, World Intellectual Property Organization, , ,

Production Method 12

940-06-7

Reaction Conditions

Reference

Mineral acid-free preparation of nitro compounds from pyridine or its derivatives

, Japan, , ,

Production Method 13

940-06-7

Reaction Conditions

Reference

Pyrimidines. LXIV. Ring transformations in reactions of heterocyclic compounds with nucleophiles. XX. Conversion of 5-nitropyrimidine into 3,5-dinitropyridine. A novel ring transformation

Van der Plas, H. C.; Jongejan, H.; Koudijs, A., Journal of Heterocyclic Chemistry, 1978, 15(3), 485-7

Production Method 14

181294-58-6

100-52-7

940-06-7

1845711-80-9

Reaction Conditions

1.1 Reagents: p-Toluenesulfonic acid Solvents: Ethanol ;  20 h, 80 °C

Reference

Construction of 3,5-dinitrated 1,4-dihydropyridines modifiable at 1,4-positions by a reaction of β-formyl-β-nitroenamines with aldehydes

Asahara, Haruyasu; Hamada, Mai; Nakaike, Yumi; Nishiwaki, Nagatoshi, RSC Advances, 2015, 5(110), 90778-90784

3,5-Dinitropyridine Raw materials

• Pyridine, 2-hydrazinyl-3,5-dinitro-
• 2-Propenal, 3-[(1,1-dimethylethyl)amino]-2-nitro-
• Benzaldehyde
• 2-Chloro-3,5-dinitropyridine
• 5-Nitropyrimidine

3,5-Dinitropyridine Preparation Products

• 3,5-Dinitropyridine (940-06-7)
• 1-(1,1-Dimethylethyl)-1,4-dihydro-3,5-dinitro-4-phenylpyridine (1845711-80-9)

• 1. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 2. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
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• 4. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
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  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305

• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds C-nitro compounds
• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds Organic nitro compounds C-nitro compounds

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