Production Method 1

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Benzoyl peroxide Solvents: Carbon tetrachloride ;  7 h, 80 °C → reflux

Reference

Versatile Synthesis of Isoquinolines and Isochromenes by Pd-Catalyzed Oxidative Carbonylation of (2-Alkynyl)benzylidene-amine Derivatives

Gabriele, Bartolo; Veltri, Lucia; Maltese, Vito; Spina, Rosella; Mancuso, Raffaella; et al, European Journal of Organic Chemistry, 2011, 2011(28), 5626-5635

Production Method 2

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Benzoyl peroxide Solvents: Carbon tetrachloride ;  overnight, 80 °C → reflux

Reference

Accelerated Discovery of Novel Ponatinib Analogs with Improved Properties for the Treatment of Parkinson's Disease

Kaiser, Thomas M. ; Dentmon, Zackery W. ; Dalloul, Christopher E.; Sharma, Savita K.; Liotta, Dennis C., ACS Medicinal Chemistry Letters, 2020, 11(4), 491-496

Production Method 3

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: Benzil Solvents: Carbon tetrachloride

Reference

Synthesis of bromonitrobenzyl bromides

Gogolimska, Barbara; Gruda, Ilona, Acta Poloniae Pharmaceutica, 1963, 20(4), 345-6

Production Method 4

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Benzoyl peroxide Solvents: Carbon tetrachloride ;  16 h, 78 °C

Reference

Preparation of 2-aminopyrimidine derivatives as kinase inhibitors and its application

, China, , ,

Production Method 5

940-05-6

Reaction Conditions

Reference

Preparation of aromatic sulfone, sulfonamide, and sulfonate compounds as aldosterone receptor (mineralocorticoid receptor) (MR) modulators

, World Intellectual Property Organization, , ,

Production Method 6

940-05-6

Reaction Conditions

Reference

Inactivation of acetylcholinesterase with a bretylium tosylate photoaffinity probe

Branchini, Bruce R.; Lajiness, Evelyn J., Biochimica et Biophysica Acta, 1986, 884(1), 135-41

Production Method 7

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: 1,2-Dichloroethane ;  24 h, 65 °C

Reference

Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1

Lee, Yujeong ; Onishi, Yoshiyuki; McPherson, Lisa; Kietrys, Anna M.; Hebenbrock, Marian; et al, ACS Chemical Biology, 2022, 17(8), 2074-2087

Production Method 8

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Benzoyl peroxide Solvents: Carbon tetrachloride ;  overnight, rt → 80 °C

Reference

Abelson non-tyrosine kinase compounds for the treatment of neurodegenerative diseases

, World Intellectual Property Organization, , ,

Production Method 9

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ;  20 °C; 12 h, 70 °C

Reference

Protein kinase AKT3 modulators and methods of use thereof for preventing and treating various diseases

, World Intellectual Property Organization, , ,

Production Method 10

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Benzoyl peroxide Solvents: Carbon tetrachloride ;  5 - 6 h, reflux

Reference

Pd(II)-Catalyzed Non-Directed Benzylic C(sp3)-H Activation: Cascade C(sp3)-S Bond Cleavage to Access Benzaldehydes from Benzylphenyl Sulfides and Sulfoxides

Joshi, Asha; Iqbal, Zafar; Kandwal, Pankaj; De, Saroj Ranjan, Asian Journal of Organic Chemistry, 2022, 11(12),

Production Method 11

7745-93-9

940-05-6

Reaction Conditions

1.1 Reagents: Benzoyl peroxide ,  N-Bromosuccinimide Solvents: Carbon tetrachloride ;  16 h, reflux; reflux → rt

Reference

Preparation of benzoxazepines, benzodiazepines, and benzazepines derivatives as agents for treating disorders involving modulation of ryanodine receptors

, World Intellectual Property Organization, , ,

Production Method 12

940-05-6

Reaction Conditions

Reference

Preparation and formulation of alkylsulfonylbiphenyl and aminosulfonylbiphenyl derivatives as selective COX-2 inhibitors

, World Intellectual Property Organization, , ,

2-bromo-1-(bromomethyl)-4-nitro-benzene Raw materials

• 2-Bromo-4-nitrotoluene

2-bromo-1-(bromomethyl)-4-nitro-benzene Preparation Products

• 2-bromo-1-(bromomethyl)-4-nitro-benzene (940-05-6)

• 1. An investigation on the second-order nonlinear optical response of cationic bipyridine or phenanthroline iridium(iii) complexes bearing cyclometallated 2-phenylpyridines with a triphenylamine substituent?
  David B. Cordes,Alexandra M. Z. Slawin,Stefania Righetto,Denis Jacquemin,Eli Zysman-Colman,Véronique Guerchais Dalton Trans., 2018,47, 8292-8300
• 2. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 3. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
  Quan Xiang,Yiqin Chen,Zhiqin Li,Kaixi Bi,Guanhua Zhang,Huigao Duan Nanoscale, 2016,8, 19541-19550
• 4. An ion-gating multinanochannel system based on a copper-responsive self-cleaving DNAzyme?
  Yang Chen,Di Zhou,Zheyi Meng,Jin Zhai Chem. Commun., 2016,52, 10020-10023
• 5. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 7745-93-9(2-Bromo-4-nitrotoluene)
• 5274-71-5(2-Bromo-4-nitrobenzaldehyde)
• 82617-49-0(2-Bromo-3-Nitrobenzyl Bromide)
• 52121-34-3(2-Bromo-1-ethyl-4-nitrobenzene)
• 53906-84-6(2-Bromo-1,3-dimethyl-5-nitrobenzene)
• 58579-54-7(2-Bromo-6-nitrobenzyl Bromide)
• 82420-34-6(4-Bromo-1-(bromomethyl)-2-nitrobenzene)
• 7149-70-4(2-Bromo-5-nitrotoluene)
• 110127-07-6(1,3-Dibromo-2-methyl-5-nitrobenzene)
• 139194-80-2(1-BROMO-3-(BROMOMETHYL)-5-NITROBENZENE)