Production Method 1

94-22-4

94-12-2

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ,  AV 17X8 Solvents: 1-Propanol ;  5 - 300 min, 1 atm, 40 °C

Reference

Hydrogenation of aromatic nitro compounds on palladium-containing anion-exchange resins

Abdullaev, M. G.; Gebekova, Z. G., Petroleum Chemistry, 2016, 56(2), 146-150

Production Method 2

150-13-0

94-12-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: 1-Propanol ;  rt; reflux

Reference

Chain-growth polycondensation via the substituent effect: Investigation of the monomer structure on synthesis of poly(N-octyl-benzamide)

Prehn, Frederick C. Jr; Etz, Brian D.; Reese, Caleb J.; Vyas, Shubham; Boyes, Stephen G., Journal of Polymer Science (Hoboken, 2020, 58(17), 2389-2406

Production Method 3

150-13-0

94-12-2

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  4 h, reflux
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  pH 7 - 8

Reference

Structure-activity relationships (SAR) research of thiourea derivatives as dual inhibitors targeting both HIV-1 capsid and human cyclophilin A

Chen, Kan; Tan, Zhiwu; He, Meizi; Li, Jiebo; Tang, Shixing; et al, Chemical Biology & Drug Design, 2010, 76(1), 25-33

Production Method 4

94-12-2

Reaction Conditions

Reference

Effects of alkyl chain length on molecular interactions. II. Complex isomerism in the alkyl p-aminobenzoate-picric acid systems

Togashi, Atsushi; Matsunaga, Yoshio, Bulletin of the Chemical Society of Japan, 1987, 60(3), 1171-3

Production Method 5

94-12-2

Reaction Conditions

Reference

Boron trifluoride ethyl ether as an effective catalyst in the synthesis of alkyl p-aminobenzoates

Kadaba, Pankaja K.; Carr, Martin; Tribo, Mark; Triplett, John; Glasser, A. C., Journal of Pharmaceutical Sciences, 1969, 58(11), 1422-3

Production Method 6

150-13-0

94-12-2

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  5 min, cooled; 4 h, reflux

Reference

Microsynthesis of a novel herbicide, propyl 4-[2-[(4, 6-dimethoxy-2- pyrimidinyl)oxy] benzylamino]benzoate

Yang, Zhengmin; Ye, Qingfu; Tang, Qinghong; Lu, Long, Henong Xuebao, 2006, 20(5), 423-428

Production Method 7

150-13-0

94-12-2

Reaction Conditions

1.1 Catalysts: Thionyl chloride ;  cooled; reflux
1.2 Reagents: Sodium carbonate Solvents: Water ;  pH 7 - 8

Reference

Study on the facile synthesis of alkyl 4-aminobenzoate

Xiong, Yang; Xia, Ke-xue; Yang, Long; Li, Sheng; Tian, Hui-hui; et al, Xinan Daxue Xuebao, 2013, 35(9), 74-79

Production Method 8

1098351-02-0

94-12-2

Reaction Conditions

1.1 Reagents: Diethyl carbonate Catalysts: Zinc triflate ;  18 h, 97 °C

Reference

Zinc-Catalyzed Esterification of N-β-Hydroxyethylamides: Removal of Directing Groups under Mild Conditions

Nishii, Yuji; Hirai, Takahiro; Fernandez, Sarah; Knochel, Paul; Mashima, Kazushi, European Journal of Organic Chemistry, 2017, 2017(34), 5010-5014

Production Method 9

150-13-0

94-12-2

Reaction Conditions

1.1 Catalysts: Sulfuric acid
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Synthesis and evaluation of alkyl 4-(2-cyanoacetamido)benzoates for antioxidant and analgesic activities

Madhavi, K.; Pavani, Ch, Journal of Chemical and Pharmaceutical Research, 2017, 9(3), 341-345

Production Method 10

94-12-2

Reaction Conditions

Reference

Liquid-phase hydrogenation of p-nitrobenzoic acid esters on palladium catalysts

Morogina, K.; Nasibulin, A. A.; Klyuev, M. V., Neftekhimiya, 1998, 38(4), 277-281

Production Method 11

94-12-2

Reaction Conditions

Reference

Steric effects in acid-catalyzed decomposition and base-catalyzed cyclization of 1-(2-alkoxycarbonylphenyl)-3-phenyltriazenes

Pytela, Oldrich; Halama, Ales, Collection of Czechoslovak Chemical Communications, 1996, 61(5), 751-763

Production Method 12

25800-30-0

94-12-2

Reaction Conditions

1.1 Reagents: Sodium tert-butoxide ,  Ammonia Catalysts: [1,3-Bis[2,6-bis[3-methyl-1-(2-methylpropyl)butyl]phenyl]-4,5-dichloro-1,3-dihyd… Solvents: 1,4-Dioxane ;  6 h, 60 °C

Reference

Selective Cross-Coupling of (Hetero)aryl Halides with Ammonia To Produce Primary Arylamines using Pd-NHC Complexes

Lombardi, Christopher; Day, Jonathan; Chandrasoma, Nalin; Mitchell, David; Rodriguez, Michael J.; et al, Organometallics, 2017, 36(2), 251-254

Production Method 13

62-23-7

94-12-2

150-13-0

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: 12-Tungstophosphoric acid ,  Nickel platinum alloy Solvents: 1-Propanol ;  8 h, 0.1 MPa, 80 °C

Reference

A nano-reactor based on PtNi@metal-organic framework composites loaded with polyoxometalates for hydrogenation-esterification tandem reactions

Chen, Luning; Zhang, Xibo; Zhou, Jinhong; Xie, Zhaoxiong; Kuang, Qin; et al, Nanoscale, 2019, 11(7), 3292-3299

Propyl 4-Aminobenzoate Raw materials

• sunbrella
• Benzoic acid, 4-nitro-,propyl ester
• 4-amino-N-(2-hydroxyethyl)-N-methylbenzamide
• 4-Nitrobenzoic acid
• propyl 4-chlorobenzoate

Propyl 4-Aminobenzoate Preparation Products

• Propyl 4-Aminobenzoate (94-12-2)
• sunbrella (150-13-0)

• 1. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 3. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 4. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 5. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Propyl 4-Aminobenzoate: A Comprehensive Overview

Propyl 4-Aminobenzoate (CAS No. 94-12-2) is a chemical compound that has garnered significant attention in various industries due to its versatile properties and applications. This compound, also known as 4-aminobenzoic acid propyl ester, belongs to the class of benzoates and is widely used in pharmaceuticals, cosmetics, and food additives. Its structure consists of a benzene ring with an amino group (-NH?) at the para position and a propyl ester group (-O-C?H?) attached to the carboxylic acid moiety.

The synthesis of Propyl 4-Aminobenzoate typically involves the esterification of 4-aminobenzoic acid with propanol, often catalyzed by acids such as sulfuric acid or enzymes. This reaction yields a stable ester that is soluble in organic solvents and exhibits mild acidic properties due to the presence of the amino group. The compound's solubility and stability make it suitable for various industrial applications, particularly in formulations where controlled release of active ingredients is desired.

One of the most notable applications of Propyl 4-Aminobenzoate is in the pharmaceutical industry, where it serves as an intermediate in the synthesis of drugs targeting cardiovascular diseases, inflammation, and bacterial infections. Recent studies have highlighted its potential as a precursor for developing anti-inflammatory agents and antimicrobial compounds, owing to its ability to modulate cellular signaling pathways and inhibit bacterial growth.

In the cosmetics sector, Propyl 4-Aminobenzoate is valued for its role as a stabilizer and emulsifier in skincare products. Its ability to enhance product consistency and prevent separation makes it a key ingredient in lotions, creams, and sunscreens. Additionally, research has shown that it can act as a mild skin conditioning agent, improving the texture and appearance of the skin without causing irritation.

The food industry has also embraced Propyl 4-Aminobenzoate as a food additive, particularly as an acidity regulator and flavor enhancer. Its mild acidic taste makes it ideal for balancing flavors in beverages and processed foods. Recent advancements have explored its use in functional foods aimed at improving gut health by promoting beneficial bacterial growth.

From an environmental perspective, Propyl 4-Aminobenzoate has been studied for its biodegradability and eco-friendly properties. Research indicates that it undergoes rapid microbial degradation under aerobic conditions, making it a safer alternative to more persistent chemicals in certain applications.

In conclusion, Propyl 4-Aminobenzoate (CAS No. 94-12-2) is a multifaceted compound with diverse applications across various industries. Its chemical stability, solubility, and biocompatibility make it an invaluable ingredient in modern formulations. As scientific research continues to uncover new potentials for this compound, its role in advancing healthcare, cosmetics, and food production is expected to grow significantly.

• 94-25-7(Butamben)
• 54667-43-5(Poly(1,4-butanediol) bis(4-aminobenzoate))
• 49744-35-6(Ethanol,2-(2-methoxyethoxy)-, 1-(4-aminobenzoate))
• 342611-08-9(Benzocaine-d4)
• 57609-64-0(Propane-1,3-diyl bis(4-aminobenzoate))
• 23239-88-5(Benzocaine hydrochloride)
• 113010-52-9(PEG-25 PABA)
• 9011-18-1(Dextran Sulfate Sodium Salt)
• 582-33-2(Ethyl 3-aminobenzoate)
• 152699-63-3(Dibenzyl 5-aminoisophthalate)