Production Method 1

93983-13-2

93983-14-3

Reaction Conditions

1.1 Reagents: Pyridine ,  Thionyl chloride Solvents: Dichloromethane ;  rt; 2.5 h, rt
1.2 Solvents: Water ;  0.5 h, rt

Reference

New derivatives of 3,4-dihydroisoquinoline-3-carboxylic acid with free-radical scavenging, D-amino acid oxidase, acetylcholinesterase and butyrylcholinesterase inhibitory activity

Solecka, Jolanta; Guspiel, Adam; Postek, Magdalena; Ziemska, Joanna; Kawecki, Robert; et al, Molecules, 2014, 19(10), 15866-15890

Production Method 2

93983-13-2

93983-14-3

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Benzene ,  Water

Reference

Synthesis and renal vasodilator activity of some dopamine agonist 1-aryl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diols: halogen and methyl analogs of fenoldopam

Weinstock, Joseph; Ladd, David L.; Wilson, James W.; Brush, Charles K.; Yim, Nelson C. F.; et al, Journal of Medicinal Chemistry, 1986, 29(11), 2315-25

Production Method 3

93983-13-2

93983-14-3

Reaction Conditions

1.1 Reagents: Thionyl chloride

Reference

Synthesis and renal vasodilator activity of 2-chlorodopamine and N-substituted derivatives

McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W., Journal of Medicinal Chemistry, 1986, 29(9), 1586-90

2-chloro-1-(chloromethyl)-3,4-dimethoxybenzene Raw materials

• (2-Chloro-3,4-dimethoxyphenyl)methanol

2-chloro-1-(chloromethyl)-3,4-dimethoxybenzene Preparation Products

• 2-chloro-1-(chloromethyl)-3,4-dimethoxybenzene (93983-14-3)

• 1. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 2. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
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• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• 4. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 5. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Dimethoxybenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Methoxybenzenes Dimethoxybenzenes

• 62584-51-4(Benzene, 1,1'-oxybis[2,3,5,6-tetrachloro-4-(chloromethyl)-)
• 62028-88-0(1,1'-Biphenyl, 2,2'-dichlorodimethoxy-)
• 920008-51-1(1,2-Benzenediol, 4-chloro-3-methoxy-5-methyl-)
• 62028-89-1(1,1'-Biphenyl, 2,2'-dichlorotrimethoxy-)
• 1215996-60-3(5-chloro-6-(chloromethyl)-2,3-dihydro-1,4-benzodioxine)
• 848694-08-6(Benzene,2-chloro-1-(chloromethyl)-3,4,5-trimethoxy-)
• 642084-73-9(Methanol, [[4-chloro-5-(chloromethyl)-1,2-phenylene]bis(oxy)]bis-)
• 104113-74-8(1-chloro-5-(chloromethyl)-2,3-dimethoxybenzene)
• 62924-32-7(Benzene, 2-chloro-1-methoxy-3,5-dimethyl-)
• 52516-44-6(2-Chloro-1-(chloromethyl)-3-methoxybenzene)