Cas no 939400-34-7 (trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid)

Technical Introduction: trans-3-(tert-Butoxycarbonylamino)cyclobutanecarboxylic acid is a protected cyclic β-amino acid derivative, featuring a trans-configured cyclobutane ring with a Boc-protected amine and a carboxylic acid functional group. This compound serves as a versatile intermediate in organic synthesis and medicinal chemistry, particularly for the construction of peptidomimetics and constrained analogs. The tert-butoxycarbonyl (Boc) group ensures selective deprotection under mild acidic conditions, while the rigid cyclobutane scaffold imparts conformational restraint, enhancing target selectivity in drug design. Its high purity and stability make it suitable for applications in peptide modification and small-molecule development. The carboxyl group further allows for coupling reactions, enabling modular incorporation into complex architectures.
trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid structure
939400-34-7 structure
Product Name:trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid
CAS No:939400-34-7
MF:C10H17NO4
MW:215.24628329277
MDL:MFCD06657681
CID:1000395
PubChem ID:24720963
Update Time:2025-06-07

trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid Chemical and Physical Properties

Names and Identifiers

    • trans-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid
    • (trans)-3-(tert-butoxycarbonylamino)cyclobutanecarboxylic acid
    • trans-3-(tert-Butoxycarbonylamino) cyclobutanecarboxylic acid
    • TRANS-3-(TERT-BUTOXYCARBONYLAMINO)CYCLOBUTANECARBOXYLIC ACID
    • cis-3-(tert-Butoxycarbonylamino)cyclobutanecarboxylic acid
    • 3-(tert-Butoxycarbonylamino)cyclobutanecarboxylic acid
    • 3-(Boc-amino)cyclobutanecarboxylic Acid
    • 3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid
    • cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid
    • cis-3-(Boc-amino)cyclobutanecarboxylic Acid
    • 3-{[(tert-butoxy)carbon
    • trans-3-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic acid (ACI)
    • trans-3-[(tert-Butoxycarbonyl)amino]cyclobutanecarboxylic acid
    • CS-W021751
    • J-525002
    • 3-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-1-cyclobutanecarboxylic acid
    • trans-3-(Boc-amino)cyclobutane-1-carboxylic acid
    • SCHEMBL668998
    • cis-3-(Boc-amino)cyclobutane-1-carboxylic acid
    • AKOS015841370
    • CS-W022613
    • (1s,3s)-3-{[(tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid
    • 3-[(2-methylpropan-2-yl)oxycarbonylamino]cyclobutane-1-carboxylic acid
    • 3-{[(tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid
    • MFCD09864181
    • A845025
    • AKOS015949254
    • EN300-88035
    • SCHEMBL10205784
    • cis-3-[(tert-Butoxycarbonyl)amino]cyclobutanecarboxylic acid
    • SCHEMBL15499602
    • EN300-71871
    • trans-3-(t-Butoxycarbonylamino)cyclobutanecarboxylic acid
    • DTXSID50915397
    • MFCD06657681
    • MFCD06657680
    • AS-33462
    • 3-{[tert-Butoxy(hydroxy)methylidene]amino}cyclobutane-1-carboxylic acid
    • 1008773-79-2
    • PB23702
    • (1r,3r)-3-[(tert-butoxycarbonyl)amino]cyclobutane-1-carboxylic acid
    • J-520076
    • SY023655
    • SY028408
    • J-510989
    • 3-(Boc-amino)cyclobutane-1-carboxylic acid
    • cis-3-(t-Butoxycarbonylamino)cyclobutanecarboxylic acid
    • SCHEMBL668997
    • SCHEMBL758581
    • CS-0047808
    • AKOS015841487
    • 946152-72-3
    • PB30834
    • DB-372107
    • cis-3-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylicacid
    • SY028409
    • 939400-34-7
    • DA-19664
    • EN300-101709
    • trans-3-tert-Butoxycarbonylamino-cyclobutanecarboxylic acid
    • PB26190
    • (1r,3r)-3-{[(tert-butoxy)carbonyl]amino}cyclobutane-1-carboxylic acid
    • KLCYDBAYYYVNFM-KNVOCYPGSA-N
    • trans-3-(BOC-amino)cyclobutanecarboxylic acid
    • KLCYDBAYYYVNFM-LJGSYFOKSA-N
    • CYCLOBUTANECARBOXYLIC ACID, 3-[[(1,1-DIMETHYLETHOXY)CARBONYL]AMINO]-, CIS-
    • AS-42931
    • DS-17302
    • trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid
    • MDL： MFCD06657681
    • Inchi： 1S/C10H17NO4/c1-10(2,3)15-9(14)11-7-4-6(5-7)8(12)13/h6-7H,4-5H2,1-3H3,(H,11,14)(H,12,13)/t6-,7-
    • InChI Key： KLCYDBAYYYVNFM-LJGSYFOKSA-N
    • SMILES： N([C@@H]1C[C@@H](C(=O)O)C1)C(=O)OC(C)(C)C

Computed Properties

  • Exact Mass: 215.11575802g/mol
  • Monoisotopic Mass: 215.11575802g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 4
  • Complexity: 263
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 75.6
  • XLogP3: 1

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trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid Production Method

Production Method 1

Reaction Conditions
Reference
Preparation of substituted pyrazolo[1,5-a]pyridines as inhibitors of FGFR tyrosine kinases for the treatment of FGFRs-mediated diseases
, World Intellectual Property Organization, , ,

Production Method 2

Reaction Conditions
1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran ;  12 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 5
Reference
LSD1 inhibitor and preparation method and application thereof
, World Intellectual Property Organization, , ,

Production Method 3

Reaction Conditions
Reference
Compounds and methods for treating Friedreich's ataxia
, World Intellectual Property Organization, , ,

trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid Raw materials

trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid Preparation Products

trans-3-(Tert-butoxycarbonylamino)cyclobutanecarboxylic acid Related Literature

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