Cas no 938440-64-3 (Ku-0063794)

Ku-0063794 is a highly selective and potent inhibitor of the mechanistic target of rapamycin (mTOR) kinase, specifically targeting both mTORC1 and mTORC2 complexes. It exhibits an IC50 value of approximately 10 nM for mTOR, demonstrating superior specificity compared to other kinase inhibitors. Ku-0063794 effectively blocks downstream signaling pathways, including phosphorylation of S6K1 and Akt, making it a valuable tool for studying mTOR-dependent cellular processes. Its cell-permeable nature allows for efficient intracellular delivery, facilitating in vitro and in vivo research applications. The compound is chemically stable and suitable for long-term studies, offering researchers a reliable means to investigate mTOR's role in metabolism, cell growth, and proliferation.

Ku-0063794 structure

Product Name:Ku-0063794

CAS No:938440-64-3

MF:C₂₅H₃₁N₅O₄

MW:465.54474568367

MDL:MFCD22666594

CID:69597

PubChem ID:329825382

Update Time:2025-07-02

Ku-0063794 Chemical and Physical Properties

Names and Identifiers

- KU-0063794
- 5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
- (5-(2-((2R6S)-26-dimethylmorpholino)-4-morpholinopyrido[23-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
- BENZENEMETHANOL, 5-[2-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-4-(4-MORPHOLINYL)PYRIDO[2,3-D]PYRIMIDIN-7-YL]-2-METHOXY-, RE...
- KU 0063794
- Ku-0063794 (KU0063794) Relative stereochemistry
- rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morp holinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
- KU0063794
- 81HJG228AB
- (5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
- C25H31N5O4
- (5-(2-((2S,6R)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
- 5-[2-[(2R,6S)-2,6-DIMETHYL-4-MORPHOLINYL]-4-(4-MORPHOLI
- rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol (ACI)
- KU 63794
- KU 0063794, >=98% (HPLC)
- KU-63794
- SMR004702805
- 5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyben
- [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[5,6-e]pyrimidin-7-yl]-2-methoxyphenyl]methanol
- DTXSID50239782
- EX-A045
- BCP01931
- Q27158643
- {5-[2-((2S,6R)-2,6-Dimethyl-morpholin-4-yl)-4-morpholin-4-yl-pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-phenyl}-methanol
- BRD-K67566344-001-01-8
- EX-5106
- [5-[2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-morpholin-4-ylpyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol
- MLS006011007
- UNII-81HJG228AB
- rel-5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
- mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3
- SCHEMBL290211
- Ku63794
- Benzenemethanol, 5-(2-((2R,6S)-2,6-dimethyl-4-morpholinyl)-4-(4-morpholinyl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxy-
- rel-5-[2-[(2R,6S)-2,6-dimethyl-4-mo rpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin -7-yl]-2-methoxybenzenemethanol
- AKOS005145564
- (5-{2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-4-(morpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl}-2-methoxyphenyl)methanol
- GTPL9360
- BCP9000821
- (5-(2-(cis-2,6-Dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol
- SDCCGSBI-0654360.P001
- F17370
- BRD-K67566344-001-07-5
- CHEBI:85572
- 938440-64-3
- CS-0065
- AS-16210
- J-501490
- HY-50710
- s1226
- CCG-264870
- MFCD22666594
- NCGC00250396-01
- CHEMBL1078983
- AC-31515
- BRD-K67566344-001-08-3
- SW220188-1
- BDBM50310989
- HB2250
- Ku-0063794
- MDL： MFCD22666594
- Inchi： 1S/C25H31N5O4/c1-16-13-30(14-17(2)34-16)25-27-23-20(24(28-25)29-8-10-33-11-9-29)5-6-21(26-23)18-4-7-22(32-3)19(12-18)15-31/h4-7,12,16-17,31H,8-11,13-15H2,1-3H3/t16-,17+
- InChI Key： RFSMUFRPPYDYRD-CALCHBBNSA-N
- SMILES： C[C@@H]1O[C@H](C)CN(C2N=C3N=C(C4C=CC(OC)=C(CO)C=4)C=CC3=C(N3CCOCC3)N=2)C1

Computed Properties

Exact Mass: 465.23800
Monoisotopic Mass: 465.23760449g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 9
Heavy Atom Count: 34
Rotatable Bond Count: 5
Complexity: 643
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 2
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 93.1
XLogP3: 2.6

Experimental Properties

Density: 1.248
Melting Point: 275.01 °C
Boiling Point: 694.30 °C at 760 mmHg
Refractive Index: 1.61
Solubility: DMSO: >2mg/mL (warmed)
PSA: 93.07000
LogP: 2.77290

Ku-0063794 Security Information

Symbol:
Signal Word：Danger
Hazard Statement： H301
Warning Statement： P301 + P310
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Hazard Category Code： 25
Safety Instruction： 45
Hazardous Material Identification：
Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month

Ku-0063794 Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	K127530-5mg	Ku-0063794	938440-64-3	≥98%	5mg	￥514.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	K127530-100mg	Ku-0063794	938440-64-3	≥98%	100mg	￥2765.90	2023-09-02
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.	K127530-25mg	Ku-0063794	938440-64-3	≥98%	25mg	￥2056.90	2023-09-02
S e l l e c k ZHONG GUO	S1226-10mM (1mL in DMSO)	KU-0063794	938440-64-3	99.91%	10mM (1mL in DMSO)	￥1464.74	2023-09-16
S e l l e c k ZHONG GUO	S1226-5mg	KU-0063794	938440-64-3	99.91%	5mg	￥727.74	2023-09-16
S e l l e c k ZHONG GUO	S1226-10mg	KU-0063794	938440-64-3	99.91%	10mg	￥1405.09	2023-09-16
S e l l e c k ZHONG GUO	S1226-50mg	KU-0063794	938440-64-3	99.91%	50mg	￥3857.09	2023-09-16
S e l l e c k ZHONG GUO	S1226-100mg	KU-0063794	938440-64-3	99.63%	100mg	￥5488.69	2022-04-26
DC Chemicals	DC3101-100 mg	Ku-0063794	938440-64-3	>98%	100mg	$400.0	2022-02-28
DC Chemicals	DC3101-250 mg	Ku-0063794	938440-64-3	>98%	250mg	$800.0	2022-02-28

Ku-0063794 Production Method

Production Method 1

908142-03-0

938443-23-3

938440-64-3

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Ethanol , Water ; 30 min, 140 °C

Reference

: Pyrido-, pyrazo- and pyrimido-pyrimidine derivatives as mTOR inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer

, United States, , ,

Production Method 2

938443-23-3

1009303-77-8

938440-64-3

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Ethanol , Toluene ; 140 °C

Reference

: Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Pike, Kurt G.; Malagu, Karine; Hummersone, Marc G.; Menear, Keith A.; Duggan, Heather M. E.; et al, Bioorganic & Medicinal Chemistry Letters, 2013, 23(5), 1212-1216

Ku-0063794 Raw materials

Ku-0063794 Preparation Products

Ku-0063794 (938440-64-3)

Ku-0063794 Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:938440-64-3)Ku-0063794

Order Number:A25182

Stock Status:in Stock

Quantity:50mg/100mg/250mg/1g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 04:18

Price ($):235.0/356.0/663.0/994.0

Email:[email protected]

Product Official Link

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