Production Method 1

5856-77-9

2935-90-2

938063-63-9

Reaction Conditions

1.1 Solvents: Dichloromethane ;  10 °C → 0 °C
1.2 Reagents: Ammonia ;  pH 7, 0 °C; pH 7, 0 °C → 65 °C; 1.8 h, pH 7, 65 °C
1.3 Reagents: Water ;  30 min

Reference

Method for reducing production cost of α-dimethyl butyryl-S-propionic acid methyl ester

, China, , ,

Production Method 2

5856-77-9

2935-90-2

938063-63-9

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  18 h, 50 °C

Reference

Method for green synthesizing simvastatin side chain from 2,2-dimethylbutyric acid

, China, , ,

Production Method 3

5856-77-9

2935-90-2

938063-63-9

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Diethyl ether ;  0 °C; 2 h, 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Methods and materials for making simvastatin and related compounds

, India, , ,

Production Method 4

5856-77-9

2935-90-2

938063-63-9

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Diethyl ether ;  0 °C; 2 h, 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Efficient synthesis of simvastatin by use of whole-cell biocatalysis

Xie, Xinkai; Tang, Yi, Applied and Environmental Microbiology, 2007, 73(7), 2054-2060

Production Method 5

5856-77-9

2935-90-2

938063-63-9

Reaction Conditions

1.1 Reagents: Diisopropylethylamine Solvents: Isopropyl acetate ;  10 min, 2 °C; 2 h, 25 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Improved enzymatic production of simvastatin and it's derivatives using mutant lovD acyltransferases

, World Intellectual Property Organization, , ,

Production Method 6

5856-77-9

2935-90-2

938063-63-9

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Tetrahydrofuran ;  rt → -10 °C; -10 - -5 °C; 3 - 4 h, -10 °C → 15 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  rt; 2 h, neutralized, 25 - 35 °C

Reference

Preparation method of simvastatin side chain

, China, , ,

Production Method 7

5856-77-9

2935-90-2

938063-63-9

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Diethyl ether ;  0 °C
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Biosynthesis of simvastatin

Zhu, Liping; Ren, Yuhong; Sun, Changlei; Zhou, Jianping; Wei, Dongzhi, Shengwu Jiagong Guocheng, 2011, 9(5), 11-16

Methyl 3-(2,2-Dimethylbutanoylthio)propanoate Raw materials

• 2,2-Dimethylbutanoyl Chloride
• methyl 3-sulfanylpropanoate

Methyl 3-(2,2-Dimethylbutanoylthio)propanoate Preparation Products

• Methyl 3-(2,2-Dimethylbutanoylthio)propanoate (938063-63-9)

• 1. Excess electrons in lithium–ethylamine solutions—density, electrical conductivity and EPR studies
  Phys. Chem. Chem. Phys., 1999,1, 3561-3565
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 4. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

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