Production Method 1

76-09-5

66826-78-6

937591-69-0

Reaction Conditions

1.1 Reagents: Iodine ,  (T-4)-Trihydro[N-(1-methylethyl)-2-propanamine]boron Solvents: Dichloromethane ;  rt; 5 min, rt
1.2 Reagents: Diisopropylethylamine Solvents: Dichloromethane ;  5 min, rt
1.3 Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Toluene ;  rt; 12 - 16 h, reflux; reflux → rt; rt → 0 °C
1.4 Solvents: Diethyl ether ;  4 h, 0 °C → rt

Reference

Aminoboranes via Tandem Iodination/Dehydroiodination for One-Pot Borylation

Ramachandran, P. Veeraraghavan ; Hamann, Henry J.; Mishra, Sukriti, ACS Omega, 2022, 7(16), 14377-14389

Production Method 2

66826-78-6

73183-34-3

937591-69-0

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Toluene ;  18 h, 90 °C

Reference

Boron insertion into alkyl ether bonds via zinc/nickel tandem catalysis

Lyu, Hairong ; Kevlishvili, Ilia ; Yu, Xuan ; Liu, Peng ; Dong, Guangbin, Science (Washington, 2021, 372(6538), 175-182

Production Method 3

66826-78-6

73183-34-3

937591-69-0

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,2-Dimethoxyethane ;  15 min, 150 °C; 150 °C → rt

Reference

New 2-amino-3,5-dihydro-4H-imidazol-4-one derivatives and their use as BACE inhibitors for treatment of cognitive impairment, Alzheimer disease, neurodegeneration and dementia

, World Intellectual Property Organization, , ,

Production Method 4

132464-84-7

73183-34-3

937591-69-0

Reaction Conditions

1.1 Reagents: Dimethylformamide ,  Sodium hydride Solvents: Acetonitrile ;  24 h, 35 °C
1.2 Reagents: Water ;  35 °C

Reference

Solvent Anions Enable Photoinduced Borylation and Phosphonation of Aryl Halides via EDA Complexes

Pan, Lei; Deckert, Macy M.; Cooke, Maria Victoria; Bleeke, Annika R.; Laulhe, Sebastien, Organic Letters, 2022, 24(35), 6466-6471

Production Method 5

519054-55-8

937591-69-0

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Cobalt (functionalized in to cobalt oxide core shell supported on silica) ,  Silica Solvents: Tetrahydrofuran ;  24 h, 50 bar, 135 °C

Reference

Development of a General and Selective Nanostructured Cobalt Catalyst for the Hydrogenation of Benzofurans, Indoles and Benzothiophenes

Zhou, Bei; Chandrashekhar, Vishwas G.; Ma, Zhuang; Kreyenschulte, Carsten; Bartling, Stephan; et al, Angewandte Chemie, 2023, 62(10),

Production Method 6

132464-84-7

73183-34-3

937591-69-0

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: 1,4-Dioxane ;  3 h, rt → 100 °C

Reference

Preparation of imidazole derivatives as NMDA (N-methyl-D-aspartate) receptor subtype 2B selective blockers

, World Intellectual Property Organization, , ,

Production Method 7

66826-78-6

73183-34-3

937591-69-0

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ;  16 h, 90 °C
1.2 Solvents: Water

Reference

Preparation of 1-[2-[(6-amino-9H-purin-9-yl)methyl]phenyl]pyrrolidin-3-amine derivatives as mixed lineage leukemia 1 (MLL1) inhibitors and anti-cancer agents

, World Intellectual Property Organization, , ,

Production Method 8

519054-55-8

937591-69-0

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  15 psi, rt → 40 °C; 48 h, 40 °C

Reference

Pyrimidine sulfamide derivative, preparation method and medical application thereof

, World Intellectual Property Organization, , ,

Production Method 9

66826-78-6

73183-34-3

937591-69-0

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: 1,4-Dioxane ;  rt; 16 h, 80 °C

Reference

Preparation of 2-(thiophenyl)thiopyran-1,1-dioxides as MMP or TNF-α inhibitors

, World Intellectual Property Organization, , ,

2-(2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Raw materials

• 2,3-Dimethylbutane-2,3-diol
• 5-Iodo-2,3-dihydro-1-benzofuran
• Benzofuran-5-boronic acid pinacol ester
• 5-bromo-2,3-dihydro-1-benzofuran
• Bis(pinacolato)diborane

2-(2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Preparation Products

• 2-(2,3-dihydro-1-benzofuran-5-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (937591-69-0)

• 1. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 5. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389

• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 1378368-37-6(2-(3-isopropoxy-4-isopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 934586-50-2(2-(2,3-dihydro-1-benzofuran-7-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 1002727-88-9(2-(Chroman-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 1154740-64-3(4,4,5,5-tetramethyl-2-(4-methyl-2,3-dihydro-1-benzofuran-5-yl)-1,3,2-dioxaborolane)
• 445303-12-8(2-(2,3-dihydro-1-benzofuran-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 1378367-56-6(2-(3-(tert-butyl)-4-(cyclopentyloxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 1378367-41-9(2-(3-(tert-butyl)-4-isopropoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 1378367-46-4(2-(4-isopropoxy-3-isopropylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 1221824-16-3(4-(2-Phenylethoxy)phenylboronic acid pinacol ester)
• 937591-99-6(2-(Chroman-8-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)