Production Method 1

71701-92-3

934279-60-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  rt; 1 h, -65 °C
1.2 -65 °C; 1 h, -65 °C
1.3 Reagents: Ammonium chloride Solvents: Water

Reference

Triheterocyclic compound, preparation method therefor, and application thereof

, World Intellectual Property Organization, , ,

Production Method 2

71701-92-3

934279-60-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Toluene ,  Hexane ;  -65 °C; 30 min, -65 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Pyridine and pyrazine derivatives as CETP inhibitors, their preparation, pharmaceutical compositions, and use in therapy

, World Intellectual Property Organization, , ,

Production Method 3

71701-92-3

934279-60-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Toluene ,  Hexane ;  -65 °C; 30 min, -65 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Pyridinyl amine derivatives as inhibitors of cholesteryl ester transfer protein (CETP) and their preparation, pharmaceutical compositions and use in the treatment of cardiovascular diseases

, World Intellectual Property Organization, , ,

Production Method 4

71701-92-3

934279-60-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Toluene ,  Hexane ;  1.5 h, -78 °C
1.2 0.5 h, -78 °C
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Preparation of spirocyclic biaryl amides compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors

, United States, , ,

Production Method 5

71701-92-3

934279-60-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Toluene ,  Hexane ;  -65 °C; 30 min, -65 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Preparation of oxazolidin-2-one derivatives as CETP inhibitors

, World Intellectual Property Organization, , ,

Production Method 6

71701-92-3

934279-60-4

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Toluene ;  -78 °C; 1.5 h, -78 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Oxazolidinone derivative as CETP inhibitor and its preparation

, World Intellectual Property Organization, , ,

2-Chloro-3-formyl-5-trifluoromethylpyridine Raw materials

• 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine

2-Chloro-3-formyl-5-trifluoromethylpyridine Preparation Products

• 2-Chloro-3-formyl-5-trifluoromethylpyridine (934279-60-4)

• 1. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 2. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 4. Excellent kinetics of single-phase Gd-doped ceria fuel electrodes in solid oxide cells?
  Andreas Nenning,Manuel Holzmann,Jürgen Fleig,Alexander K. Opitz Mater. Adv., 2021,2, 5422-5431
• 5. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755

• 174008-48-1(2-chloro-4-(trifluoromethyl)pyridine-3-carbaldehyde)
• 1099597-75-7(2-Chloro-5-(trifluoromethyl)pyridine-3-carbonyl chloride)
• 505084-59-3(2-chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid)
• 1245915-41-6(1-(6-Chloro-5-(trifluoromethyl)pyridin-3-yl)ethanone)
• 914636-56-9(2,6-Dichloro-4-(trifluoromethyl)nicotinaldehyde)
• 944904-73-8(1-2-chloro-5-(trifluoromethyl)pyridin-3-ylethan-1-one)
• 920494-32-2(3-Quinolinecarboxaldehyde, 2-chloro-8-(trifluoromethyl)-)
• 1113049-90-3(6-Chloro-5-(trifluoromethyl)nicotinaldehyde)
• 1621615-09-5(2-Chloro-7-(trifluoromethyl)quinoline-3-carbaldehyde)
• 1211539-56-8(2-Chloro-3-(trifluoromethyl)isonicotinaldehyde)