Production Method 1

1611489-44-1

934-78-1

Reaction Conditions

1.1 Reagents: Sodium perborate (NaBO3) tetrahydrate Solvents: Tetrahydrofuran ,  Water ;  14 h, rt
1.2 Reagents: Sodium thiosulfate Solvents: Water ;  rt

Reference

Radical Hydroarylation of Functionalized Olefins and Mechanistic Investigation of Photocatalytic Pyridyl Radical Reactions

Seath, Ciaran P.; Vogt, David B.; Xu, Zihao; Boyington, Allyson J.; Jui, Nathan T., Journal of the American Chemical Society, 2018, 140(45), 15525-15534

Production Method 2

934-78-1

Reaction Conditions

Reference

Elimination of formaldehyde

, Japan, , ,

Production Method 3

108-48-5

934-78-1

1077-36-7

1076-58-0

Reaction Conditions

1.1 Solvents: Water ;  12 h, 135 °C

Reference

A dimethacrylate cross-linker cleavable under thermolysis or alkaline hydrolysis conditions: synthesis, polymerization, and degradation

Elladiou, Marios; Patrickios, Costas S., Chemical Communications (Cambridge, 2016, 52(15), 3135-3138

2-(6-methylpyridin-2-yl)ethan-1-ol Raw materials

• Cap B2 Solution [2,6-Lutidine-Acetonitrile (6:4)]
• 2-Methyl-6-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethyl]pyridine

2-(6-methylpyridin-2-yl)ethan-1-ol Preparation Products

• 2,6-Pyridinediethanol (1077-36-7)
• 2-(6-methylpyridin-2-yl)ethan-1-ol (934-78-1)
• 2-(6-Methyl-2-pyridinyl)-1,3-propanediol (1076-58-0)

• 1. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 4. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 5. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Methylpyridines

Recent Advances in the Study of 2-(6-Methylpyridin-2-yl)ethan-1-ol (CAS: 934-78-1) in Chemical Biology and Pharmaceutical Research

The compound 2-(6-methylpyridin-2-yl)ethan-1-ol (CAS: 934-78-1) has recently garnered significant attention in the field of chemical biology and pharmaceutical research. This molecule, characterized by its pyridine-based structure, has shown promising potential in various applications, including drug development, enzyme inhibition, and as a building block for more complex chemical entities. Recent studies have explored its synthesis, biological activity, and potential therapeutic uses, making it a focal point for researchers aiming to develop novel pharmacological agents.

One of the key areas of interest is the role of 2-(6-methylpyridin-2-yl)ethan-1-ol in modulating enzyme activity. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy as an inhibitor of specific cytochrome P450 enzymes, which are crucial in drug metabolism. The study highlighted the compound's ability to selectively bind to the active sites of these enzymes, suggesting its potential use in enhancing the bioavailability of co-administered drugs. This finding opens new avenues for combinatorial therapies where enzyme inhibition is desired.

In addition to its enzyme inhibitory properties, recent research has also focused on the synthetic pathways for 2-(6-methylpyridin-2-yl)ethan-1-ol. A team from the University of Cambridge reported a novel, high-yield synthesis method in 2024, which utilizes green chemistry principles to minimize environmental impact. This method not only improves the scalability of production but also reduces the use of hazardous reagents, aligning with the growing demand for sustainable pharmaceutical manufacturing processes.

Another significant development is the exploration of 2-(6-methylpyridin-2-yl)ethan-1-ol as a precursor for the synthesis of more complex molecules. A recent paper in Organic Letters detailed its use in the construction of heterocyclic compounds, which are often found in drugs targeting neurological disorders. The study demonstrated that the hydroxyl group in 2-(6-methylpyridin-2-yl)ethan-1-ol can be readily functionalized, allowing for the creation of diverse derivatives with varying biological activities.

Despite these advancements, challenges remain in fully understanding the pharmacokinetics and toxicology of 2-(6-methylpyridin-2-yl)ethan-1-ol. Preliminary in vivo studies have shown promising results, but further research is needed to assess its long-term safety and efficacy. Researchers are particularly interested in its potential off-target effects and how these might be mitigated in therapeutic applications.

In conclusion, 2-(6-methylpyridin-2-yl)ethan-1-ol (CAS: 934-78-1) represents a versatile and promising compound in chemical biology and pharmaceutical research. Its dual role as an enzyme inhibitor and a synthetic building block underscores its potential in drug development. Future studies should focus on optimizing its pharmacological properties and exploring its applications in treating complex diseases. The ongoing research in this area is expected to yield significant breakthroughs in the coming years.

• 1122-69-6(2-Ethyl-6-methylpyridine)
• 71172-28-6(2-(2-Ethoxyethyl)-6-methylpyridine)
• 71172-56-0(2-(2-Methoxyethyl)-6-methylpyridine)
• 28672-54-0(2-(2-ethoxyethyl)pyridine)
• 1077-36-7(2,6-Pyridinediethanol)
• 194228-34-7((2R)-2-Pyridin-2-ylpropan-1-ol)
• 103-74-2(2-Pyridineethanol)
• 22186-60-3(2-(1H-pyrrol-2-yl)ethan-1-ol)
• 114-91-0(Pyridine,2-(2-methoxyethyl)-)
• 153502-26-2(Hydroxylamine,O-[2-(2-pyridinyl)ethyl]-, hydrochloride (1:2))