Production Method 1

1118-66-7

563-41-7

934-48-5

Reaction Conditions

1.1 Solvents: Water
1.2 Reagents: Sodium bicarbonate Solvents: Water
1.3 Solvents: Dichloromethane

Reference

Reactions of β-aminoenones with acetylhydrazine, semicarbazide and methoxycarbonylhydrazine. Synthesis of 1-acetyl-, 1-carboxamide- or methyl 1-carboxylated pyrazole derivatives

Alberola, Angel; Calvo, Luis; Ortega, Alfonso Gonzalez; Sadaba, M. Luisa; Sanudo, M. Carmen; et al, Heterocycles, 1999, 51(11), 2675-2686

Production Method 2

57-56-7

934-48-5

Reaction Conditions

1.1 Catalysts: 1,3,5,7-Tetraazoniatricyclo[3.3.1.13,7]decane, 1,3,5,7-tetrakis(3-sulfopropyl)-,… Solvents: Water ;  5 min, rt

Reference

Application of a multi-SO3H Bronsted acidic ionic liquid in water: a highly efficient and reusable catalyst for the regioselective and scaled-up synthesis of pyrazoles under mild conditions

Safaei, Shirin; Mohammadpoor-Baltork, Iraj; Khosropour, Ahmad Reza; Moghadam, Majid; Tangestaninejad, Shahram; et al, RSC Advances, 2012, 2(13), 5610-5616

Production Method 3

57-56-7

934-48-5

Reaction Conditions

1.1 Catalysts: Amberlyst 70 Solvents: Water ;  5 - 30 min, 30 °C

Reference

Greener and facile aqueous synthesis of pyrazoles using Amberlyst-70 as a recyclable catalyst

Chandak, Hemant S.; Lad, Nitin P.; Dange, Dipali S., Green Chemistry Letters and Reviews, 2012, 5(2), 135-138

Production Method 4

934-48-5

Reaction Conditions

Reference

An improved synthesis of 3,6-diamino-1,2,4,5-tetrazine. I

Coburn, Michael D.; Ott, Donald G., Journal of Heterocyclic Chemistry, 1990, 27(7), 1941-5

Production Method 5

934-48-5

Reaction Conditions

Reference

Substituted ureas and carbamoyl compounds

, German Democratic Republic, , ,

Production Method 6

934-48-5

Reaction Conditions

Reference

Nitrogeneous five-membered heterocycles. Some pyrazole derivatives with possible hypoglycemic action

Cojocaru, Zenaida; Bicleseanu, Cornelia, Revista Medicala (Tirgu-Mures, 1971, 17(3-4), 415-21

Production Method 7

1118-66-7

563-41-7

934-48-5

Reaction Conditions

1.1 Solvents: Water

Reference

Reaction of β-aminoenones with hydrazine derivatives. Regioselective synthesis of pyrazoles

Alberola, A.; Andres, C.; Gonzalez Ortega, A.; Pedrosa, R.; Vicente, M., Anales de Quimica, 1987, 83(1), 55-61

Production Method 8

112423-54-8

934-48-5

Reaction Conditions

1.1 Reagents: Water Solvents: Tetrahydrofuran

Reference

Synthesis of 1-oxo-1H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-3-olates. Ring-chain tautomerism in the series of bicyclic dipolar heterocycles

Boettcher, Andreas; Debaerdemaeker, Tony; Radziszewski, Juliusz G.; Friedrichsen, Willy, Chemische Berichte, 1988, 121(5), 895-907

Production Method 9

57-56-7

934-48-5

Reaction Conditions

1.1 Reagents: Monopotassium phosphate Solvents: Water

Reference

Organic reactions in aqueous solution at room temperature. II. Influence of pH on condensations involving the linkage of carbon to carbon, of carbon to nitrogen, and of carbon to sulfur

Bethell, J. R.; Maitland, P., Journal of the Chemical Society, 1961, 5211, 5211-16

Production Method 10

57-56-7

934-48-5

Reaction Conditions

Reference

Product class 1: pyrazoles

Stanovnik, B.; Svete, J., Science of Synthesis, 2002, 12, 15-225

Production Method 11

934-48-5

Reaction Conditions

Reference

Organic reactions in the aqueous medium. Part VI. Synthesis of substituted pyrazoles and pyrazolones

Ali, Sh. Shaukat; Ashraf, C. M.; Younas, M.; Ehsan, A., Pakistan Journal of Scientific and Industrial Research, 1993, 36(12), 502-10

Production Method 12

934-48-5

Reaction Conditions

Reference

Syntheses with silver or sodium pyrazoles. III. Reactions of sodium pyrazoles

Reimlinger, Hans; Noels, Alfred; Jadot, Josef; Van Overstraeten, Andre, Chemische Berichte, 1970, 103(6), 1954-9

Production Method 13

57-56-7

934-48-5

110-20-3

Reaction Conditions

1.1 Solvents: Water ;  rt; 2 h, rt

Reference

New Reaction Products of Acetylacetone with Semicarbazide Derivatives

Glukhacheva, Vera S.; Il'yasov, Sergey G.; Kazantsev, Igor V.; Shestakova, Elena O.; Il'yasov, Dmitri S.; et al, ACS Omega, 2021, 6(12), 8637-8645

3,5-Dimethylpyrazole-1-carboxamide Raw materials

• 4-Aminopent-3-en-2-one
• Semicarbazide
• Semicarbazide hydrochloride

3,5-Dimethylpyrazole-1-carboxamide Preparation Products

• 3,5-Dimethylpyrazole-1-carboxamide (934-48-5)
• Acetone semicarbazone (110-20-3)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles
• Solvents and Organic Chemicals Organic Compounds Heterocyclic Compounds

• 90008-47-2(1H-Pyrazole-1-carboxamide,5-ethyl-3-methyl-)
• 254734-51-5(1H-Pyrazole-1-carboxamide,5-methyl-3-(1-methylethyl)-)
• 873-50-7(3-Methylpyrazole-1-carboxamide)
• 113630-76-5(1H-Pyrazole-1-carboxamide,3-methyl-5-(1-methylethyl)-)
• 873-24-5(1H-Pyrazole-1-carboxamide, 5-methyl-)
• 50476-16-9(1H-Pyrazole, 1,1'-carbonylbis[3-methyl-)
• 100365-72-8(3-methylpyrazole-1-carboxamide)
• 74731-27-4(1H-Pyrazole-1-carboxamide,N,N,5-trimethyl-)
• 347874-48-0(1H-Pyrazole-1-carboxamide,4-amino-3,5-dimethyl-)
• 10199-62-9(1H-Pyrazole-1-carboxamide,N,3,5-trimethyl-)