- Pyrrole derivatives useful for the treatment of cytokine-mediated diseases and their preparation, World Intellectual Property Organization, , ,
Cas no 933986-97-1 (2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine)
933986-97-1 structure
Product Name:2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
CAS No:933986-97-1
MF:C15H23BN2O2
MW:274.166323900223
MDL:MFCD06798273
CID:93230
PubChem ID:43811062
Update Time:2024-10-26
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Chemical and Physical Properties
Names and Identifiers
-
- 2-Pyrrolidin-1-ylpyridine-5-boronic acid pinacol ester
- 6-(1-Pyrrolidinyl)pyridine-3-boronic acid pinacol ester
- (2-Pyrrolidin-1-yl)pyridine-5-boronic acid pinacol ester
- 2-(Pyrrolidino)pyridine-5-boronic acid pinacol ester
- 3,4-Pyridazinediamine
- 6-[(pyrroline-1-yl)pyridine-3-yl]boronic acid pinacol ester
- 2-(1-Pyrrolidinyl)-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine
- 6-(PYRROLIDIN-1-YL)PYRIDINE-3-BORONIC ACID, PINACOL ESTER
- 2-(1-Pyrrolidinyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (ACI)
- 2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridine
- 6-(Pyrrolidin-1-yl)pyridine-3-boronic acid pinacol ester
- 2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- J-505409
- SCHEMBL1484906
- 2-pyrrolidin-1-yl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- A849898
- HGBBKKWVSQBIMM-UHFFFAOYSA-N
- CS-0109731
- ethylthioethylmethacrylate
- 2-(pyrrolidin-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
- 933986-97-1
- FD10007
- AS-3091
- 2-Pyrrolidin-1-ylpyridine-5-boronic acid pinacol ester, AldrichCPR
- AB29929
- 2-(pyrrolidin-1-yl)-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
- MFCD06798273
- FT-0649096
- DTXSID20656447
- AM20061628
- 2-Pyrrolidinopyridine-5-boronic Acid Pinacol Ester
- EN300-1706271
- 2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1.3.2-dioxaborolan-2-yl)pyridine
- AKOS000282831
- SY008962
-
- MDL： MFCD06798273
- Inchi： 1S/C15H23BN2O2/c1-14(2)15(3,4)20-16(19-14)12-7-8-13(17-11-12)18-9-5-6-10-18/h7-8,11H,5-6,9-10H2,1-4H3
- InChI Key： HGBBKKWVSQBIMM-UHFFFAOYSA-N
- SMILES： O1B(C2=CN=C(C=C2)N2CCCC2)OC(C)(C)C1(C)C
Computed Properties
- Exact Mass: 274.18500
- Monoisotopic Mass: 274.185
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 4
- Heavy Atom Count: 20
- Rotatable Bond Count: 2
- Complexity: 340
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 34.6A^2
Experimental Properties
- Density: 1.09
- Melting Point: 118-121°C
- Boiling Point: 413.4°C at 760 mmHg
- Flash Point: 203.8°C
- Refractive Index: 1.531
- PSA: 34.59000
- LogP: 2.04600
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Security Information
- Signal Word：Danger
- Hazard Statement： H315; H319; H335
- Warning Statement： P261; P280; P305+P351+P338; P304+P340; P405; P501
- Hazardous Material transportation number：UN 2811 6.1 / PGIII
- Hazard Category Code： 22-36/37/38-25
- Safety Instruction： S26; S36/37/38
-
Hazardous Material Identification：
- Storage Condition：Store at room temperature
- Risk Phrases：R22; R36/37/38
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBEB0757-1 G |
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
933986-97-1 | 95% | 1g |
￥ 904.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PBEB10184-1 G |
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
933986-97-1 | 95% | 1g |
￥ 574.00 | 2021-05-07 | |
| Alichem | A029184826-10g |
2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
933986-97-1 | 95% | 10g |
$378.42 | 2023-08-31 | |
| Chemenu | CM137125-5g |
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
933986-97-1 | 0.95 | 5g |
$225 | 2021-08-05 | |
| Fluorochem | 050441-1g |
6-(Pyrrolidin-1-yl)pyridine-3-boronic acid pinacol ester |
933986-97-1 | 95% | 1g |
￡80.00 | 2022-03-01 | |
| Fluorochem | 050441-5g |
6-(Pyrrolidin-1-yl)pyridine-3-boronic acid pinacol ester |
933986-97-1 | 95% | 5g |
￡240.00 | 2022-03-01 | |
| SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd. | BD157763-250mg |
2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
933986-97-1 | 97% | 250mg |
￥66.0 | 2024-04-17 | |
| SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd. | BD157763-1g |
2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
933986-97-1 | 97% | 1g |
￥216.0 | 2024-04-17 | |
| SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd. | BD157763-5g |
2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
933986-97-1 | 97% | 5g |
￥622.0 | 2024-04-17 | |
| SHANG HAI BI DE YI YAO KE JI GU FEN Co., Ltd. | BD157763-10g |
2-(Pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine |
933986-97-1 | 97% | 10g |
￥2320 | 2021-08-03 |
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ; 1 h, -78 °C
1.2 -78 °C; > 2 h, -78 °C; overnight, rt
1.3 Reagents: Ammonium chloride
1.2 -78 °C; > 2 h, -78 °C; overnight, rt
1.3 Reagents: Ammonium chloride
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Potassium acetate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: 1,4-Dioxane ; 3 h, 110 °C
Reference
- Preparation of heterocyclic compounds and compositions as modulators of TLR signaling, World Intellectual Property Organization, , ,
Production Method 3
Reaction Conditions
1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran , Hexane ; -78 °C; 30 min, -78 °C
1.2 2 h, -78 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; rt
1.2 2 h, -78 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; rt
Reference
- Novel chemical compounds (variants) and the use thereof to treat oncological diseases, World Intellectual Property Organization, , ,
Production Method 4
Reaction Conditions
1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran , Hexane ; rt → -78 °C; -78 °C; 30 min, -78 °C
1.2 2 h, -78 °C; -78 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water
1.2 2 h, -78 °C; -78 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water
Reference
- Preparation of bicyclic aromatic compounds as inhibitors of mitogen-activated protein kinase-activated protein kinase-2, World Intellectual Property Organization, , ,
Production Method 5
Reaction Conditions
Reference
- Novel heterocyclic compounds for the diagnosis of TDP-43 proteinopathies and their preparation, World Intellectual Property Organization, , ,
Production Method 6
Reaction Conditions
Reference
- Novel chemical compounds (variants) and the use thereof to treat oncological diseases, Russian Federation, , ,
Production Method 7
Reaction Conditions
Reference
- Preparation of pyrazolo[3,4-c]quinoline compounds as phosphatidylinositol 3 kinase inhibitors for therapeutic applications, World Intellectual Property Organization, , ,
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Raw materials
- 5-Bromo-2-(pyrrolidin-1-yl)pyridine
- 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- Bis(pinacolato)diborane
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Preparation Products
2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Related Literature
-
Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
-
Adeline Huiling Loo,Alessandra Bonanni,Martin Pumera Analyst, 2013,138, 467-471
-
5. An autonomous self-optimizing flow machine for the synthesis of pyridine–oxazoline (PyOX) ligands?Eric Wimmer,Daniel Cortés-Borda,Solène Brochard,Elvina Barré,Charlotte Truchet,Fran?ois-Xavier Felpin React. Chem. Eng., 2019,4, 1608-1615
933986-97-1 (2-(pyrrolidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine) Related Products
- 1225066-77-2((3R)-1-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylpyrrolidin-3-ol)
- 1257554-16-7(N-Ethyl-N-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine)
- 1073354-41-2(2-(Pyrrolidin-1-yl)pyridine-3-boronic Acid Pinacol Ester)
- 918524-63-7(1-Methyl-4-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)piperazine)
- 1353880-12-2(N-3-(Pyrrolidin-1-yl)propyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine)
- 940285-00-7(2-(4-ethyl-piperazin-1-yl)pyridine-5-boronic acid pinacol)
- 871125-86-9(2-Piperazinopyridine-5-boronic Acid Pinacol Ester)
- 1311165-58-8(N,N-Diethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine)
- 1015242-02-0(1-Methyl-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]-1,4-diazepane)
- 852228-08-1(2-(Piperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine)
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