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  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625
• 3. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 4. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation
  Feng Shi,Kunping Yan,Mingli Peng,Xiao Cheng,Yanling Luo,Xuemei Chen,V. A. L. Roy,Zuankai Wang Nanoscale, 2012,4, 747-751
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Halopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Halopyrimidines

Introduction to 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde (CAS No. 933686-24-9)

2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde, with the CAS number 933686-24-9, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound is characterized by its unique pyrimidine core and functional groups, making it a valuable intermediate in the synthesis of various biologically active molecules.

The chemical structure of 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde consists of a pyrimidine ring substituted with two chlorine atoms at the 2 and 4 positions and a methyl group at the 6 position. The presence of the aldehyde group at the 5 position further enhances its reactivity and utility in synthetic transformations. This combination of functional groups provides a platform for the development of novel compounds with diverse biological activities.

In recent years, 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde has been extensively studied for its potential applications in drug discovery and development. One of the key areas of interest is its use as a building block in the synthesis of antiviral agents. Research has shown that derivatives of this compound exhibit potent antiviral activity against a range of viruses, including influenza and herpes simplex virus (HSV). For instance, a study published in the Journal of Medicinal Chemistry highlighted the synthesis and evaluation of several 2,4-dichloro-6-methylpyrimidine-based derivatives that demonstrated significant inhibition of viral replication.

Beyond antiviral applications, 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde has also shown promise in the development of anticancer agents. The pyrimidine scaffold is known to be an important structural motif in many anticancer drugs, and modifications to this core can lead to compounds with enhanced therapeutic properties. A recent study in Cancer Research reported the synthesis and biological evaluation of a series of 2,4-dichloro-6-methylpyrimidine-based analogs that exhibited selective cytotoxicity against various cancer cell lines, including breast and lung cancer cells.

The versatility of 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde extends to its use in the synthesis of other bioactive molecules. For example, it has been utilized as a key intermediate in the preparation of agrochemicals with herbicidal properties. The ability to fine-tune the chemical structure through substitution reactions allows for the design of compounds with optimized biological activity and reduced environmental impact. A study published in Pesticide Biochemistry and Physiology demonstrated the synthesis and herbicidal activity of several 2,4-dichloro-6-methylpyrimidine-based compounds that showed high efficacy against common weed species.

In addition to its applications in drug discovery and agrochemicals, 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde has also been explored for its potential as a fluorescent probe. The unique electronic properties of the pyrimidine ring and the presence of functional groups make it suitable for designing molecules that can be used to monitor biological processes at the molecular level. A recent publication in Analytical Chemistry described the development of a fluorescent probe based on 2,4-dichloro-6-methylpyrimidine, which was used to detect specific biomolecules with high sensitivity and selectivity.

The synthetic accessibility of 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde is another factor contributing to its widespread use in research. Various methods have been developed for its preparation, including multistep synthetic routes that involve reactions such as nucleophilic substitution, condensation, and oxidation. These methods have been optimized to achieve high yields and purity levels, making it readily available for laboratory-scale synthesis and large-scale production.

In conclusion, 2,4-Dichloro-6-methylpyrimidine-5-carbaldehyde (CAS No. 933686-24-9) is a multifaceted compound with significant potential in various fields of chemistry and biology. Its unique chemical structure and reactivity make it an invaluable tool for researchers working on drug discovery, agrochemical development, and analytical chemistry. As ongoing research continues to uncover new applications and properties, this compound is likely to play an increasingly important role in advancing scientific knowledge and technological innovation.

• 430440-91-8(2,4-Dichloro-6-(chloromethyl)-5-methylpyrimidine)
• 26138-87-4(Ethanone, 1-(4-chloro-2,6-dimethyl-5-pyrimidinyl)-)
• 1780-32-1(2,4-Dichloro-5,6-dimethylpyrimidine)
• 36745-93-4(Methyl 2,4-dichloro-6-methylpyrimidine-5-carboxylate)
• 56035-64-4(2,4-Dichloro-6-methylpyrimidine-5-carbonitrile)
• 861033-35-4(2,4-dichloro-5-ethyl-6-methylpyrimidine)
• 691886-07-4(2,4-DICHLORO-6-METHYL-5-PROPYLPYRIMIDINE)
• 67434-65-5(4-Chloro-5,6-dimethylpyrimidine)
• 871254-61-4(2,4-Dichloropyrimidine-5-carbaldehyde)
• 16768-43-7(2,4-Dichloro-5-(chloromethyl)-6-methylpyrimidine)