Cas no 93368-76-4 (2-(azidomethyl)-1,3,5-trimethylbenzene)

2-(Azidomethyl)-1,3,5-trimethylbenzene is a specialized aromatic compound featuring an azidomethyl functional group attached to a symmetrically substituted benzene ring. This structure makes it a valuable intermediate in organic synthesis, particularly for click chemistry applications, where the azide group enables efficient cycloaddition reactions with alkynes. The 1,3,5-trimethyl substitution enhances steric stability and may influence reactivity in selective transformations. Its well-defined molecular architecture is advantageous for constructing complex frameworks in pharmaceuticals, polymers, and materials science. The compound's stability under controlled conditions and compatibility with diverse reaction environments further underscore its utility in research and industrial applications. Proper handling is essential due to the potential reactivity of the azide moiety.

2-(azidomethyl)-1,3,5-trimethylbenzene structure

93368-76-4 structure

Product Name:2-(azidomethyl)-1,3,5-trimethylbenzene

CAS No:93368-76-4

MF:C₁₀H₁₃N₃

MW:175.230321645737

MDL:MFCD12545985

CID:1003352

PubChem ID:10631091

Update Time:2025-10-28

2-(azidomethyl)-1,3,5-trimethylbenzene Chemical and Physical Properties

Names and Identifiers

- 1,3,5-TRIMETHYLBENZYL AZIDE
- 2-(azidomethyl)-1,3,5-trimethylbenzene
- MDL： MFCD12545985
- Inchi： 1S/C10H13N3/c1-7-4-8(2)10(6-12-13-11)9(3)5-7/h4-5H,6H2,1-3H3
- InChI Key： QZRDSVMEBMBTKU-UHFFFAOYSA-N
- SMILES： N(CC1C(C)=CC(C)=CC=1C)=[N+]=[N-]

Computed Properties

Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Heavy Atom Count: 13
Rotatable Bond Count: 2

2-(azidomethyl)-1,3,5-trimethylbenzene Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
TRC	B536803-10mg	2,4,6-trimethylbenzyl azide	93368-76-4		10mg	$ 50.00	2022-06-07
TRC	B536803-50mg	2,4,6-trimethylbenzyl azide	93368-76-4		50mg	$ 135.00	2022-06-07
TRC	B536803-100mg	2,4,6-trimethylbenzyl azide	93368-76-4		100mg	$ 210.00	2022-06-07
abcr	AB261128-2 g	1,3,5,-Trimethylbenzylazide, 97%; .	93368-76-4	97%	2 g	€148.50	2023-07-20
abcr	AB261128-5 g	1,3,5,-Trimethylbenzylazide, 97%; .	93368-76-4	97%	5 g	€1,003.20	2023-07-20
abcr	AB261128-10 g	1,3,5,-Trimethylbenzylazide, 97%; .	93368-76-4	97%	10 g	€471.90	2023-07-20
Enamine	EN300-274664-1g	2-(azidomethyl)-1,3,5-trimethylbenzene	93368-76-4		1g	$271.0	2023-09-10
Enamine	EN300-274664-5g	2-(azidomethyl)-1,3,5-trimethylbenzene	93368-76-4		5g	$783.0	2023-09-10
Enamine	EN300-274664-10g	2-(azidomethyl)-1,3,5-trimethylbenzene	93368-76-4		10g	$1163.0	2023-09-10
abcr	AB261128-2g	1,3,5,-Trimethylbenzylazide, 97%; .	93368-76-4	97%	2g	€148.50	2025-04-15

2-(azidomethyl)-1,3,5-trimethylbenzene Suppliers

Amadis Chemical Company Limited

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(CAS:93368-76-4)2-(azidomethyl)-1,3,5-trimethylbenzene

Order Number:A1193218

Stock Status:in Stock

Quantity:1g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 02:20

Price ($):1523.0

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Additional information on 2-(azidomethyl)-1,3,5-trimethylbenzene

Recent Advances in the Application of 2-(Azidomethyl)-1,3,5-trimethylbenzene (CAS: 93368-76-4) in Chemical Biology and Pharmaceutical Research

The compound 2-(azidomethyl)-1,3,5-trimethylbenzene (CAS: 93368-76-4) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its versatile applications in click chemistry, drug discovery, and biomolecular labeling. This research briefing provides an overview of the latest developments involving this compound, focusing on its synthesis, reactivity, and potential therapeutic applications.

Recent studies have highlighted the role of 2-(azidomethyl)-1,3,5-trimethylbenzene as a key intermediate in the synthesis of bioactive molecules. Its azide functional group enables efficient participation in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of click chemistry. This property has been leveraged in the development of novel drug conjugates and probes for studying biological systems. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated its utility in creating targeted anticancer agents by conjugating it with alkyne-functionalized chemotherapeutic drugs.

In addition to its applications in drug discovery, 2-(azidomethyl)-1,3,5-trimethylbenzene has shown promise in materials science. Researchers have utilized its aromatic structure and reactive azide group to create functionalized polymers with potential applications in drug delivery systems. A recent publication in ACS Applied Materials & Interfaces described its incorporation into smart hydrogels that respond to specific biological stimuli, opening new avenues for controlled drug release.

The safety profile and pharmacokinetic properties of derivatives containing the 2-(azidomethyl)-1,3,5-trimethylbenzene moiety have also been investigated. Preliminary in vitro and in vivo studies suggest that these compounds exhibit favorable metabolic stability and low toxicity, making them attractive candidates for further pharmaceutical development. However, researchers caution that the reactivity of the azide group requires careful consideration in biological applications to avoid potential off-target effects.

Looking forward, the unique chemical properties of 2-(azidomethyl)-1,3,5-trimethylbenzene position it as a valuable tool in chemical biology and drug discovery. Ongoing research is exploring its potential in proteomics, where it may serve as a versatile labeling reagent for mass spectrometry-based studies. As synthetic methodologies continue to advance, we anticipate seeing broader applications of this compound in both academic research and industrial pharmaceutical development.

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