Production Method 1

13746-66-2

99548-54-6

93340-09-1

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Palladium diacetate Solvents: Dimethylacetamide ;  10 h, 120 °C; 120 °C → rt

Reference

Preparation of indenoisoquinolinone analogs for treating and preventing diseases

, World Intellectual Property Organization, , ,

Production Method 2

13746-66-2

99548-54-6

93340-09-1

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Palladium diacetate Solvents: Dimethylacetamide ;  10 h, 120 °C; 120 °C → rt

Reference

Preparation of indenoisoquinolinone analogs as inhibitors of poly(ADP-ribose) polymerase

, World Intellectual Property Organization, , ,

Production Method 3

13943-58-3

99548-54-6

93340-09-1

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Palladium diacetate Solvents: Dimethylamine ;  rt → 120 °C; 4 h, 120 °C; 18 h, rt

Reference

Synthesis of tropane derivatives for pharmaceutical use

, World Intellectual Property Organization, , ,

Production Method 4

13746-66-2

99548-54-6

93340-09-1

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Palladium diacetate Solvents: Dimethylacetamide ;  36.5 h, 120 °C

Reference

Preparation of substituted pyrazolopyrimidines as antagonists of the adenosine A2a receptor

, World Intellectual Property Organization, , ,

Production Method 5

93340-09-1

Reaction Conditions

Reference

Preparation of quinoline derivatives as antiallergics and antiinflammatories

, World Intellectual Property Organization, , ,

Production Method 6

93340-34-2

93340-09-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water

Reference

The oxazoline-benzyne route to 1,2,3-trisubstituted benzenes. Tandem addition of organolithiums, organocuprates, and α-lithionitriles to benzynes

Pansegrau, Paul D.; Rieker, William F.; Meyers, A. I., Journal of the American Chemical Society, 1988, 110(21), 7178-84

Production Method 7

99548-54-6

93340-09-1

Reaction Conditions

1.1 Reagents: Polyethylene glycol lauryl ether ,  Poly(methylhydrosiloxane) Catalysts: [2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][[5-(diphenylphosphino)-9,9-dimethyl-9H-xa… Solvents: Water ;  24 h, 55 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

Reference

Late-stage Pd-catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media

Thakore, Ruchita R.; Takale, Balaram S. ; Singhania, Vani; Gallou, Fabrice; Lipshutz, Bruce H., ChemCatChem, 2021, 13(1), 212-216

Production Method 8

14459-95-1

52570-33-9

93340-09-1

Reaction Conditions

1.1 Reagents: Sodium carbonate Catalysts: Palladium diacetate Solvents: Dimethylacetamide ;  10 h, rt → 120 °C

Reference

Preparation of oxoindoline derivatives as protein function modulators

, World Intellectual Property Organization, , ,

Production Method 9

93340-34-2

93340-09-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid
1.2 -

Reference

Tandem addition-rearrangement of nitrile anions to benzyne. A convenient synthesis of 3-cyano-2-alkylbenzoic acids and benzaldehydes

Meyers, A. I.; Pansegrau, Paul D., Tetrahedron Letters, 1984, 25(28), 2941-4

Production Method 10

93340-09-1

Reaction Conditions

Reference

Metabotropic glutamate receptor positive allosteric modulators and uses thereof

, World Intellectual Property Organization, , ,

Methyl 3-cyano-2-methylbenzoate Raw materials

• Potassium Ferrocyanide Trihydrate
• Benzonitrile, 3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-2-methyl-
• Potassium hexacyanoferrate
• Potassium Hexacyanoferrate(III)
• Methyl 3-bromo-2-methylbenzoate
• Methyl 3-iodo-2-methylbenzoate

Methyl 3-cyano-2-methylbenzoate Preparation Products

• Methyl 3-cyano-2-methylbenzoate (93340-09-1)

• 1. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 2. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 3. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 4. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 5. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

Comprehensive Overview of Methyl 3-cyano-2-methylbenzoate (CAS No. 93340-09-1): Properties, Applications, and Industry Insights

Methyl 3-cyano-2-methylbenzoate (CAS No. 93340-09-1) is a specialized organic compound widely recognized for its versatile applications in pharmaceuticals, agrochemicals, and fine chemical synthesis. This ester derivative, featuring a cyano group and a methyl ester moiety, has garnered significant attention due to its role as a key intermediate in the synthesis of complex molecules. Its molecular structure, C₁₀H₉NO₂, combines reactivity and stability, making it a valuable building block in modern chemical research.

In recent years, the demand for high-purity Methyl 3-cyano-2-methylbenzoate has surged, driven by advancements in drug discovery and crop protection technologies. Researchers frequently search for "synthesis methods for Methyl 3-cyano-2-methylbenzoate" or "CAS 93340-09-1 suppliers," reflecting its commercial and scientific relevance. The compound's unique electron-withdrawing cyano group enhances its utility in nucleophilic substitution reactions, a topic often explored in academic forums and patent literature.

From an industrial perspective, Methyl 3-cyano-2-methylbenzoate is pivotal in the production of active pharmaceutical ingredients (APIs). Its incorporation into heterocyclic frameworks aligns with trends in targeted therapy and personalized medicine, addressing global health challenges. Environmental considerations also play a role, as manufacturers seek "green synthesis routes for 93340-09-1" to reduce waste and energy consumption—a response to the growing emphasis on sustainable chemistry.

Analytical techniques such as HPLC and GC-MS are commonly employed to ensure the purity of CAS 93340-09-1, particularly for regulatory compliance in GMP-certified facilities. Discussions around "spectroscopic data of Methyl 3-cyano-2-methylbenzoate" frequently appear in scientific databases, underscoring the need for precise characterization. Additionally, its solubility profiles and thermal stability are critical parameters for formulation scientists optimizing drug delivery systems.

Emerging applications of Methyl 3-cyano-2-methylbenzoate extend to material science, where it serves as a precursor for functional polymers and liquid crystals. Innovations in flexible electronics and organic semiconductors have further amplified interest in this compound. Industry reports highlight collaborations between academic institutions and chemical manufacturers to explore "scalable production techniques for 93340-09-1," ensuring cost-effectiveness without compromising quality.

In conclusion, Methyl 3-cyano-2-methylbenzoate (CAS No. 93340-09-1) exemplifies the intersection of chemistry and technology. Its multifaceted roles—from pharmaceutical intermediates to advanced materials—reflect the compound's adaptability to evolving scientific and industrial needs. As research continues to uncover new potentials, this molecule remains a cornerstone in innovation-driven sectors.

• 500024-27-1(Methyl 2-cyano-3-methylbenzoate)
• 127510-94-5(Methyl 2-cyano-5-methylbenzoate)
• 6587-24-2(Methyl 2-cyanobenzoate)
• 64754-35-4(1,2-BENZENEDICARBOXYLIC ACID, 4,5-DICYANO-, DIMETHYL ESTER)
• 58331-99-0(Methyl 2,4-dicyanobenzoate)
• 103856-64-0(1,2-Benzenedicarboxylic acid, 3-cyano-, dimethyl ester)
• 714237-94-2(Methyl 2,5-dicyanobenzoate)
• 412031-32-4(1,3-Benzenedicarboxylic acid, 4-cyano-, dimethyl ester)
• 41573-40-4(1,4-Benzenedicarboxylic acid, 2,5-dicyano-, dimethyl ester)
• 1213767-07-7(Methyl 2-cyano-4-Methylbenzoate)