Production Method 1

118-90-1

933-88-0

Reaction Conditions

1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane ;  rt → 0 °C; 5 min, 0 °C
1.2 Reagents: Thionyl chloride ;  0 °C; 5 h, 85 °C

Reference

Highly Chemoselective Transamidation of Unactivated Tertiary Amides by Electrophilic N-C(O) Activation by Amide-to-Acyl Iodide Re-routing

Zuo, Dongxu; Wang, Qun; Liu, Long; Huang, Tianzeng; Szostak, Michal; et al, Angewandte Chemie, 2022, 61(24),

Production Method 2

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  1.5 h, 5 bar, 120 °C

Reference

Design and synthesis of N-benzoyl amino acid derivatives as DNA methylation inhibitors

Garella, Davide; Atlante, Sandra; Borretto, Emily; Cocco, Mattia; Giorgis, Marta; et al, Chemical Biology & Drug Design, 2016, 88(5), 664-676

Production Method 3

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  2 - 24 h, reflux

Reference

Analogues of Fenarimol Are Potent Inhibitors of Trypanosoma cruzi and Are Efficacious in a Murine Model of Chagas Disease

Keenan, Martine; Abbott, Michael J.; Alexander, Paul W.; Armstrong, Tanya; Best, Wayne M.; et al, Journal of Medicinal Chemistry, 2012, 55(9), 4189-4204

Production Method 4

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Oxalyl chloride Solvents: Benzene ;  14 h, rt

Reference

Side arm participation in lariat ether carboxylate-alkali metal cation complexes in solution

Torun, Lokman; Robison, Thomas W.; Krzykawski, Jan; Purkiss, David W.; Bartsch, Richard A., Tetrahedron, 2005, 61(35), 8345-8350

Production Method 5

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Toluene ;  16 h, reflux

Reference

Hepatitis B virus (HBV) inhibitor

, Russian Federation, , ,

Production Method 6

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ;  0.5 - 3 h, rt

Reference

Catalytic aza-Wittig Reaction of Acid Anhydride for the Synthesis of 4H-Benzo[d][1,3]oxazin-4-ones and 4-Benzylidene-2-aryloxazol-5(4H)-ones

Wang, Long; Xie, Yi-Bi; Huang, Nian-Yu; Yan, Jia-Ying; Hu, Wei-Min; et al, ACS Catalysis, 2016, 6(6), 4010-4016

Production Method 7

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  3 h, reflux

Reference

Design, synthesis and antifungal activity of novel 2,5-disubstituted 1,3,4-oxadiazoles

Yu, Xue-liang; Bao, Jian-an; Sun, Zhong-wen, Dier Junyi Daxue Xuebao, 2012, 33(9), 1019-1023

Production Method 8

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  4 h, rt → reflux

Reference

Study on synthesis of L-(-)-di(o-toluoyl)tartaric acid

Li, Zhicheng; Lu, Lihong; Jin, Yan, Huaxue Yu Shengwu Gongcheng, 2010, 27(5), 47-48

Production Method 9

118-90-1

933-88-0

Reaction Conditions

1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane ;  5 min, 0 °C
1.2 Reagents: Oxalyl chloride ;  0 °C; 4 h, 25 °C

Reference

Simple and Practical Conversion of Benzoic Acids to Phenols at Room Temperature

Xiong, Wenzhang; Shi, Qiu; Liu, Wenbo H., Journal of the American Chemical Society, 2022, 144(34), 15894-15902

Production Method 10

118-90-1

933-88-0

Reaction Conditions

1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane ;  rt → 0 °C; 5 min, 0 °C
1.2 Reagents: Oxalyl chloride ;  12 h, rt

Reference

Iridium-Catalyzed Ligand-Controlled Remote para-Selective C-H Activation and Borylation of Twisted Aromatic Amides

Hoque, Emdadul Md; Bisht, Ranjana; Unnikrishnan, Anju; Dey, Sayan; Mahamudul Hassan, Mirja Md; et al, Angewandte Chemie, 2022, 61(27),

Production Method 11

118-90-1

933-88-0

Reaction Conditions

1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane ;  5 min, 0 °C
1.2 Reagents: Oxalyl chloride ;  0 °C; 12 h, rt

Reference

Amide Effects in C-H Activation: Noncovalent Interactions with L-Shaped Ligand for meta Borylation of Aromatic Amides

Bisht, Ranjana; Hoque, Emdadul Md; Chattopadhyay, Buddhadeb, Angewandte Chemie, 2018, 57(48), 15762-15766

Production Method 12

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Dimethylformamide ;  rt → 90 °C; 3 h, 90 °C

Reference

Synthesis method of o, m, p-trifluoromethylbenzoic acid

, China, , ,

Production Method 13

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  2 h, reflux

Reference

Synthesis and insecticidal activity of new 1,2-diacyl-1-alkyl hydrazines containing fragments of methylbenzoic and methoxybenzoic acids

Kauhanka, M. U.; Ananich, S. K.; Charnou, Y. G.; Kashkan, Z. N.; Bakhanovich, L. V., Vestsi Natsyyanal'nai Akademii Navuk Belarusi, 2015, (2), 63-67

Production Method 14

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  rt → reflux; 7 h, reflux

Reference

Application of ortho-substituted benzoyl compound as antibacterial agent

, China, , ,

Production Method 15

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Thionyl chloride Solvents: Chloroform ;  rt; rt → reflux; 5 h, reflux; reflux → 90 °C

Reference

Study of synthesis and biological activity of novel N-tert-butyl biacyl hydrazine derivatives having benzofuranyl

Zhang, Xiangning; Ni, Jueping; Li, Yufeng; Jiang, Mugeng, Nanjing Nongye Daxue Xuebao, 2005, 28(4), 135-139

Production Method 16

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Chlorine ;  16 h, rt

Reference

Process for preparing phthalic acid chloride

, Korea, , ,

Production Method 17

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Cyanuric chloride Catalysts: 1-Pyrrolidinecarboxaldehyde Solvents: Acetonitrile ;  4 h, 80 °C

Reference

Formamide catalyzed activation of carboxylic acids - versatile and cost-efficient amidation and esterification

Huy, Peter H.; Mbouhom, Christelle, Chemical Science, 2019, 10(31), 7399-7406

Production Method 18

615-37-2

933-88-0

Reaction Conditions

1.1 Reagents: Benzyltriphenylphosphonium chloride Catalysts: Bis(tri-tert-butylphosphine)palladium Solvents: Toluene ;  24 h, 22 °C → 110 °C

Reference

A Palladium-Catalyzed Carbonylation Approach to Acid Chloride Synthesis

Quesnel, Jeffrey S.; Arndtsen, Bruce A., Journal of the American Chemical Society, 2013, 135(45), 16841-16844

Production Method 19

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Phosgene Solvents: Tetrahydrofuran ;  52 °C

Reference

Continuous green synthesis of o-toluoyl chloride in microchannel reactor

, China, , ,

Production Method 20

118-90-1

933-88-0

Reaction Conditions

1.1 Reagents: Triphosgene Catalysts: Dimethylformamide Solvents: Chlorobenzene ;  rt; rt → 100 °C; 30 min, 100 °C; 2 - 3 h, 100 °C; cooled

Reference

Synthesis of carboxylic acid chlorides from bis(trichloromethyl) carbonate

Xu, Xiangsheng; Du, Xiaohua; Zheng, Mei; Xu, Zhenyuan, Nongyao, 2005, 44(6), 265-266

o-Toluoyl chloride Raw materials

• O-Toluic acid
• 2-Iodotoluene

o-Toluoyl chloride Preparation Products

• o-Toluoyl chloride (933-88-0)

• 1. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 3. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 4. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 5. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives
• Solvents and Organic Chemicals Organic Compounds Organic Halides

• 3867-55-8(1,2,4-Benzenetricarbonyltrichloride)
• 21900-46-9(2,3-Dimethylbenzoyl chloride)
• 88-95-9(o-Phthaloyl dichloride)
• 117886-88-1(2-Formylbenzoyl Chloride)
• 21900-42-5(2,4-dimethylbenzoyl chloride)
• 42908-86-1(2-Chloromethyl-benzoyl Chloride)
• 938-18-1(2,4,6-Trimethylbenzoyl cloride)
• 34824-32-3(Benzoyl chloride,2,4,5-trimethyl-)
• 22328-43-4(2,5-Dimethylbenzoyl Chloride)
• 21900-37-8(Benzoyl chloride,2,6-dimethyl-)