Production Method 1

5932-27-4

93290-12-1

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  0 °C; 30 min, rt
1.2 Solvents: 1,2-Dichloroethane ;  rt → 0 °C; 0 °C; 0 °C → reflux; 30 min, reflux
1.3 Reagents: Water ;  cooled

Reference

Preparation of compounds with TRK inhibitory activity

, China, , ,

Production Method 2

93290-12-1

Reaction Conditions

Reference

Preparation of isoquinoline derivatives as c-Jun N-terminal kinase (JNK) inhibitors

, World Intellectual Property Organization, , ,

Production Method 3

624-67-9

93290-12-1

2188205-67-4

Reaction Conditions

1.1 30 min, rt
1.2 1 h, rt
1.3 Reagents: Methanol ;  10 min, rt

Reference

Stabilization and activation of unstable propynal in the zeolite nanospace and its application to addition reactions

Hayashi, Daijiro; Igura, Yuta; Masui, Yoichi; Onaka, Makoto, Catalysis Science & Technology, 2017, 7(19), 4422-4430

Production Method 4

624-67-9

93290-12-1

Reaction Conditions

1.1 Solvents: Dichloromethane ;  12 h, rt

Reference

1,3-Dipolar cycloaddition of ethyl diazoacetate to alkynes in the pores of zeolite NaY

Kobayashi, Keijiro; Igura, Yuta; Imachi, Shouhei; Masui, Yoichi; Onaka, Makoto, Chemistry Letters, 2007, 36(1), 60-61

Production Method 5

623-47-2

57331-59-6

93290-12-1

Reaction Conditions

1.1 Solvents: Diethyl ether ;  30 min, reflux
1.2 Reagents: Formic acid ;  1 h, rt

Reference

1,3-Dipolar cycloaddition in the synthesis of pyrazolyl-substituted nitronyl nitroxides

Tretyakov, E. V.; Tolstikov, S. E.; Romanenko, G. V.; Shvedenkov, Yu. G.; Sagdeev, R. Z.; et al, Russian Chemical Bulletin, 2005, 54(9), 2169-2181

Production Method 6

1444309-24-3

93290-12-1

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  6 h, 65 °C

Reference

Brominated trihalomethyl enones as versatile precursors to 3-ethoxy, -formyl, -azidomethyl, -triazolyl, and 3-aminomethyl pyrazoles

Martins, Marcos A. P.; Sinhorin, Adilson P.; Frizzo, Clarissa P.; Buriol, Lilian; Scapin, Elisandra; et al, Journal of Heterocyclic Chemistry, 2013, 50(1), 71-77

Production Method 7

624-67-9

93290-12-1

Reaction Conditions

1.1 Solvents: Diethyl ether

Reference

Some aldehydes of the pyrazole and 1,2,3-triazole series

Huttel, Rudolf, Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen, 1941, 74, 1680-7

Production Method 8

93290-12-1

Reaction Conditions

Reference

Preparation of 5-substituted 2H-pyrazole-3-carboxylic acid derivatives as agonists for the RUP25 nicotinic acid receptor for the treatment of dyslipidemia and related diseases

, World Intellectual Property Organization, , ,

Production Method 9

93290-12-1

Reaction Conditions

Reference

Substituted pyrazolyl compounds and methods employing these compounds

, United States, , ,

Ethyl 5-formyl-1H-pyrazole-3-carboxylate Raw materials

• 1H-Pyrazole-3-carboxylic acid, 5-(diethoxymethyl)-, ethyl ester
• ethyl propiolate
• Ethyl pyrazole-3-carboxylate
• Ethane, 2-diazo-1,1-dimethoxy-
• 2-Propynal (>85%, stabilized with Hydroquinone)

Ethyl 5-formyl-1H-pyrazole-3-carboxylate Preparation Products

• rel-2,7-Diethyl (4R,9S)-4,9-dihydroxy-4H,9H-dipyrazolo[1,5-a:1′,5′-d]pyrazine-2,7-dicarboxylate (2188205-67-4)
• Ethyl 5-formyl-1H-pyrazole-3-carboxylate (93290-12-1)

• 1. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 2. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 3. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
• 4. Distribution pattern and allocation of defects in hydrogenated ZnO thin films?
  Vitaly Gurylev,Chung-Yi Su,Tsong-Pyng Perng Phys. Chem. Chem. Phys., 2016,18, 16033-16038
• 5. Distribution and ecological risk assessment of typical antibiotics in the surface waters of seven major rivers, China?
  Environ. Sci.: Processes Impacts, 2021,23, 1088-1100

• 4027-57-0(Ethyl 5-methyl-1H-pyrazole-3-carboxylate)
• 37687-24-4(Diethyl 1H-pyrazole-3,5-dicarboxylate)
• 61453-48-3(Ethyl 5-(hydroxymethyl)-1H-pyrazole-3-carboxylate)
• 60612-93-3(1H-Pyrazole-3-carboxylic acid, 5-[(acetyloxy)methyl]-, methyl ester)
• 15366-34-4(methyl 1H-pyrazole-5-carboxylate)
• 5932-27-4(Ethyl pyrazole-3-carboxylate)
• 25016-17-5(Methyl 5-methyl-1H-pyrazole-3-carboxylate)
• 75436-40-7(1H-Pyrazole-3-carboxylicacid, 5-formyl-, methyl ester)
• 21056-77-9(Ethyl 1H-pyrazole-5-carboxylate)
• 60659-20-3(1H-Pyrazole-3-carboxylic acid, 5-[(acetyloxy)methyl]-, ethyl ester)