Production Method 1

1253383-91-3

932705-78-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  1 h, rt → 50 °C; 50 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 5

Reference

Preparation of piperazino-benzamides as CXCR3 receptor antagonists

, United States, , ,

Production Method 2

1253383-91-3

932705-78-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Water ;  1 h, rt
1.2 Solvents: Water ;  pH 3

Reference

Preparation of piperazine derivatives as RORγ modulators for the treatment of multiple sclerosis and ankylosing spondylitis

, Argentina, , ,

Production Method 3

1253383-91-3

932705-78-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Tetrahydrofuran ,  Water ;  1 h, rt
1.2 Reagents: Water ;  pH 3, rt

Reference

Acylpiperazine-acylaniline compounds as RORγ modulators and their preparation, pharmaceutical compositions and use in the treatment of inflammatory and autoimmune diseases

, World Intellectual Property Organization, , ,

Production Method 4

1253383-91-3

932705-78-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Tetrahydrofuran ,  Water ;  1 h, rt
1.2 Solvents: Water ;  pH 3

Reference

Preparation of piperazine derivatives as RORγ modulators

, World Intellectual Property Organization, , ,

Production Method 5

1253383-91-3

932705-78-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol ,  Tetrahydrofuran ,  Water ;  1 h, rt
1.2 Reagents: Hydrogen ion Solvents: Water ;  pH 3

Reference

N-Acylpiperazine derivatives as RORγ modulators and their preparation

, World Intellectual Property Organization, , ,

Production Method 6

932705-78-7

Reaction Conditions

Reference

Preparation of aryl-substituted pyrazoles and related compounds as nociceptin receptor antagonists

, World Intellectual Property Organization, , ,

5-Fluoro-6-methylnicotinic acid Raw materials

• Methyl 5-fluoro-6-methylnicotinate

5-Fluoro-6-methylnicotinic acid Preparation Products

• 5-Fluoro-6-methylnicotinic acid (932705-78-7)

• 1. An Aptamer Bio-barCode (ABC) assay using SPR, RNase H, and probes with RNA and gold-nanorods for anti-cancer drug screening
  Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
• 2. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
  Alvin Tanudjaja,Shinsuke Inagi,Fusao Kitamura,Toshikazu Takata,Ikuyoshi Tomita Dalton Trans., 2021,50, 3037-3043
• 3. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 4. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
  Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
• 5. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

5-Fluoro-6-methylnicotinic Acid (CAS No. 932705-78-7): A Versatile Building Block in Modern Pharmaceutical Chemistry

In the realm of heterocyclic compounds, 5-Fluoro-6-methylnicotinic acid (CAS 932705-78-7) has emerged as a crucial intermediate with significant applications in pharmaceutical development. This fluorinated nicotinic acid derivative combines the structural advantages of both fluorine substitution and methyl group positioning, making it particularly valuable for drug discovery programs targeting metabolic diseases and neurological disorders.

The molecular structure of 5-Fluoro-6-methylnicotinic acid features a pyridine ring system with strategic substitutions at the 5 and 6 positions. The fluoro group at position 5 enhances the compound's metabolic stability and membrane permeability, while the methyl group at position 6 contributes to steric effects that can influence receptor binding. These structural characteristics make it an excellent candidate for developing small molecule therapeutics, particularly in areas like diabetes management and cognitive enhancement.

Recent advances in medicinal chemistry have highlighted the importance of fluorinated heterocycles like 5-Fluoro-6-methylnicotinic acid. Pharmaceutical researchers are particularly interested in its potential as a building block for kinase inhibitors, given the growing market for targeted cancer therapies. The compound's ability to serve as a precursor for various biologically active molecules has made it a subject of numerous patent applications in the past five years.

The synthesis of 5-Fluoro-6-methylnicotinic acid typically involves multi-step processes starting from commercially available nicotinic acid derivatives. Modern synthetic approaches emphasize green chemistry principles, with recent literature reporting improved yields through microwave-assisted synthesis and flow chemistry techniques. These advancements address the growing demand for sustainable production methods in the pharmaceutical industry.

From a commercial perspective, the global market for specialty chemical intermediates like 5-Fluoro-6-methylnicotinic acid has shown steady growth, driven by increased R&D spending in the pharmaceutical sector. Analytical data suggests particular demand from contract research organizations developing next-generation metabolic modulators and central nervous system drugs. The compound's stability under various storage conditions makes it attractive for international distribution networks.

Quality control of 5-Fluoro-6-methylnicotinic acid typically involves advanced analytical techniques including HPLC purity analysis, mass spectrometry, and NMR spectroscopy. Recent technological advancements have enabled more precise characterization of isomeric impurities, which is crucial for pharmaceutical applications where even minor structural variations can significantly impact biological activity.

Environmental considerations surrounding fluorinated compounds have led to increased research into the biodegradation pathways of molecules like 5-Fluoro-6-methylnicotinic acid. Studies published in leading chemistry journals have demonstrated promising results regarding its environmental fate, with certain microbial communities showing ability to metabolize the compound under specific conditions.

The future outlook for 5-Fluoro-6-methylnicotinic acid appears promising, particularly in light of recent breakthroughs in personalized medicine and structure-based drug design. Its structural versatility allows for diverse modifications, making it valuable for combinatorial chemistry approaches. As pharmaceutical companies continue to explore novel small molecule scaffolds, the demand for high-quality fluorinated pyridine derivatives is expected to rise accordingly.

For researchers working with 5-Fluoro-6-methylnicotinic acid, proper handling procedures should always be followed, including the use of appropriate personal protective equipment. While not classified as hazardous under standard conditions, good laboratory practices recommend working in well-ventilated areas when handling any chemical substance.

In conclusion, 5-Fluoro-6-methylnicotinic acid (CAS 932705-78-7) represents an important tool in modern drug discovery, combining favorable physicochemical properties with synthetic accessibility. Its applications span multiple therapeutic areas, and ongoing research continues to uncover new potential uses for this versatile heterocyclic compound. As the pharmaceutical industry evolves toward more targeted therapies, compounds like 5-Fluoro-6-methylnicotinic acid will likely play increasingly important roles in medicinal chemistry pipelines.

• 402-66-4(5-fluoropyridine-3-carboxylic acid)
• 1253383-91-3(Methyl 5-fluoro-6-methylnicotinate)
• 1260664-00-3(3-Fluoropyridine-2,5-dicarboxylic acid)
• 780701-97-5(3-Pyridine-5,6-13c2-carboxylic acid, 5-fluoro- (9ci))
• 1211584-22-3(5-fluoro-4-methylpyridine-3-carboxylic acid)
• 1060806-01-0(4-fluoro-6-methylpyridine-3-carboxylic acid)
• 917835-70-2(5-fluoro-6-methylpyridine-3-carbaldehyde)
• 885588-17-0(5-fluoro-2-methylpyridine-4-carboxylic acid)
• 917835-69-9(3-Fluoro-5-(hydroxymethyl)-2-methylpyridine)
• 187347-17-7(3-fluoro-5-(hydroxymethyl)-2-methyl-4-Pyridinecarboxaldehyde)