Production Method 1

5370-20-7

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  -78 °C; 30 min, -78 °C
1.2 15 min, -78 °C; 30 min, -78 °C
1.3 Reagents: Ammonium chloride Solvents: Water ;  -78 °C → rt

Reference

Preparation of (heterocyclylcarbonyl)aspartic acid derivatives as caspase inhibitors

, World Intellectual Property Organization, , ,

Production Method 2

101035-54-5

932-95-6

Reaction Conditions

1.1 Reagents: Hydrochloric acid

Reference

Preparation of 2,5-thiophenedicarboxaldehyde

Sone, Cho, Bulletin of the Chemical Society of Japan, 1964, 37(8), 1197-1200

Production Method 3

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  N,N,N′,N′-Tetramethylethylenediamine Solvents: Hexane ;  1 h, reflux
1.2 Solvents: Hexane ;  1 h, 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  0 °C

Reference

Pi-Extended Ethynyl 21,23-Dithiaporphyrins: A Synthesis and Comparative Study of Electrochemical, Optical, and Self-Assembling Properties

Bromby, Ashley D.; Keller, Samantha N.; Bozek, Kevin J. A.; Williams, Vance E.; Sutherland, Todd C., Journal of Organic Chemistry, 2015, 80(19), 9401-9409

Production Method 4

3141-27-3

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Pentane ,  Tetrahydrofuran ;  -70 °C; 1 h, -70 °C
1.2 -70 °C; -70 °C → rt; 3 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Optically rewritable transparent liquid crystal displays enabled by light-driven chiral fluorescent molecular switches

Li, Juntao; Bisoyi, Hari Krishna; Tian, Jiajun; Guo, Jinbao; Li, Quan, Advanced Materials (Weinheim, 2019, 31(10),

Production Method 5

58268-08-9

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  15 min, -78 °C; 1.5 h, -78 °C
1.2 -78 °C; -78 °C → rt; 30 min, rt
1.3 Solvents: Water ;  rt
1.4 Reagents: Hydrochloric acid Solvents: Tetrahydrofuran ,  Water ;  3 h, rt
1.5 Reagents: Sodium bicarbonate Solvents: Water ;  rt

Reference

Selective Anionic Polymerization of 2,5-Divinylthiophene Derivatives

Goseki, Raita ; Oguri, Ayaka; Kurishiba, Yuki; Ishizone, Takashi, Macromolecules (Washington, 2021, 54(17), 8173-8181

Production Method 6

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  N,N,N′,N′-Tetramethylethylenediamine Solvents: Hexane ;  rt; 1.5 h, reflux
1.2 Solvents: Tetrahydrofuran ;  1.5 h, reflux; reflux → rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  0.5 h, rt

Reference

New core-substituted with electron-donating group 1,8-naphthalimides towards optoelectronic applications

Schab-Balcerzak, Ewa; Siwy, Mariola; Filapek, Michal; Kula, Slawomir; Malecki, Grzegorz; et al, Journal of Luminescence, 2015, 166, 22-39

Production Method 7

6007-86-9

932-95-6

Reaction Conditions

1.1 Reagents: Lithium acetate ,  Manganese oxide (MnO2) Solvents: Dichloromethane ;  4 h, 25 °C

Reference

Asymmetric Henry Reaction of Nitromethane with Substituted Aldehydes Catalyzed by Novel In Situ Generated Chiral Bis(β-Amino Alcohol-Cu(OAc)2·H2O Complex

Alammari, Abdullah Saleh; Al-Majid, Abdullah Mohammed; Barakat, Assem ; Alshahrani, Saeed; Ali, Mohammad; et al, Catalysts, 2021, 11(10),

Production Method 8

3141-27-3

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  -78 °C; 30 min, -78 °C → 0 °C
1.2 0 °C; 2 h, rt
1.3 Reagents: tert-Butyllithium Solvents: Pentane ;  -78 °C; 5 min, -78 °C
1.4 -78 °C; overnight, rt

Reference

The synthesis of π-electron molecular rods with a thiophene or thieno[3,2-b]thiophene core unit and sulfur alligator clips

Seidler, Arnost; Svoboda, Jiri; Dekoj, Vaclav; Chocholousova, Jana Vacek; Vacek, Jaroslav; et al, Tetrahedron Letters, 2013, 54(22), 2795-2798

Production Method 9

6007-86-9

932-95-6

Reaction Conditions

1.1 Reagents: Nitric acid

Reference

Addition of aldehydes to activated double bonds, VIII. Addition of thiophenecarbaldehydes to activated double bonds and desulfurizing hydrogenation of the addition products

Stetter, Hermann; Rajh, Bert, Chemische Berichte, 1976, 109(2), 534-40

Production Method 10

3141-27-3

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  -78 °C; 30 min, -78 °C
1.2 -78 °C; 30 min, -78 °C; 12 h, rt
1.3 Reagents: Water

Reference

Thiophene-cored isoindigo derivative-thiophene copolymer, and preparing method and application thereof

, China, , ,

Production Method 11

3141-27-3

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  0.5 h, -78 °C
1.2 0.5 h, -78 °C; overnight, rt

Reference

Preparation and purpose of isoindigo conjugated polymer containing thiophene as spatial isolation group

, China, , ,

Production Method 12

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  N,N,N′,N′-Tetramethylethylenediamine Solvents: Tetrahydrofuran ,  Hexane ;  1.5 h, 70 °C
1.2 Reagents: Hydrochloric acid ;  70 °C → rt; 0.5 h, rt

Reference

Preparation of two-dimensional strong fluorescent polyaniline material with metal ion detection performance

, China, , ,

Production Method 13

3141-27-3

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ,  Hexane

Reference

Exchange Interactions between Two Nitronyl Nitroxide or Iminyl Nitroxide Radicals Attached to Thiophene and 2,2'-Bithienyl Rings

Mitsumori, Teruyuki; Inoue, Katsuya; Koga, Noboru; Iwamura, Hiizu, Journal of the American Chemical Society, 1995, 117(9), 2467-78

Production Method 14

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  N,N,N′,N′-Tetramethylethylenediamine Solvents: Hexane ;  rt → 50 °C; 1 h, 50 °C
1.2 Solvents: Tetrahydrofuran ;  rt → -40 °C; 10 min, -40 °C; -40 °C → rt; 30 min, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  0 °C

Reference

Symmetric 32π (1.0.1.0.1.0.1) Core-Modified Heptaphyrins from Asymmetric Building Block

Gupta, Prachi; Anand, Venkataramanarao G., Organic Letters, 2021, 23(9), 3481-3485

Production Method 15

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium ,  N,N,N′,N′-Tetramethylethylenediamine Solvents: Hexane ;  rt; 40 °C → reflux; 30 min, reflux
1.2 Solvents: Tetrahydrofuran ;  reflux → -40 °C; 10 min, -40 °C; -40 °C → rt; 30 min, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  -20 °C → -5 °C
1.4 Reagents: Sodium bicarbonate Solvents: Water ;  pH 6

Reference

Organic electroluminescent elements containing thiophene-imidazol compounds, displays having them, and image sensors having them

, Japan, , ,

Production Method 16

3141-27-3

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ;  rt

Reference

Controlling the Thermoelectric Properties of Thiophene-Derived Single-Molecule Junctions

Chang, William B.; Mai, Cheng-Kang; Kotiuga, Michele; Neaton, Jeffrey B.; Bazan, Guillermo C.; et al, Chemistry of Materials, 2014, 26(24), 7229-7235

Production Method 17

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  1 h, rt; rt → -78 °C
1.2 1 h, -78 °C; 2 h, rt
1.3 Reagents: Water ;  rt
1.4 Reagents: Hydrochloric acid Solvents: Water ;  neutralized, rt

Reference

Single- and two-photon excited fluorescence of a new thiophene derivative

Lu, Ping; Wang, Fei; Xia, Guangming, Jinan Daxue Xuebao, 2004, 18(4), 350-352

Production Method 18

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  rt; 1 h, rt
1.2 -78 °C; 2 h, -78 °C
1.3 Reagents: Water ;  pH 7

Reference

Linear and nonlinear luminescence properties of thiophene based materials

Lu, Ping; Xia, Guang Ming, Journal of the Serbian Chemical Society, 2005, 70(2), 201-208

Production Method 19

932-95-6

Reaction Conditions

1.1 Reagents: N,N,N′,N′-Tetramethylethylenediamine Solvents: Hexane ;  20 min, -30 °C
1.2 Reagents: Butyllithium ;  -30 °C; 1 h, -30 °C; 1.5 h, reflux; 20 min, -30 °C
1.3 Solvents: Tetrahydrofuran ;  12 h, rt

Reference

Preparation of photovoltaic bulk phase material based on rhodanine and application thereof in organic solar cell

, China, , ,

Production Method 20

3141-27-3

932-95-6

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Diethyl ether ;  30 min, -78 °C; 30 min, -78 °C
1.2 -78 °C; overnight
1.3 Reagents: Hydrochloric acid Solvents: Water ;  -20 °C → rt

Reference

Sulfur Containing Stable Unsubstituted Heptacene Analogs

De, Puran K.; Neckers, Douglas C., Organic Letters, 2012, 14(1), 78-81

2,5-Thiophenedicarboxaldehyde Raw materials

• thiophene-2,5-diyldimethanol
• Thiophene, 2-bromo-5-(diethoxymethyl)-
• Nitrone, α,α′-2,5-thiophenediylbis[N-[p-(dimethylamino)phenyl]-
• 2,5-Dibromothiophene
• 2-(2-Thienyl)-1,3-dioxolane

2,5-Thiophenedicarboxaldehyde Preparation Products

• 2,5-Thiophenedicarboxaldehyde (932-95-6)

• 1. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
• 2. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 3. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 4. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 5. An intermolecular C–H oxidizing strategy to access highly fused carbazole skeletons from simple naphthylamines?
  Christian K. Rank,Alexander W. Jones,Tatjana Wall,Patrick Di Martino-Fumo,Sarah Schr?ck,Markus Gerhards,Frederic W. Patureau Chem. Commun., 2019,55, 13749-13752

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Thiophenes 2,5-disubstituted thiophenes

• 31486-86-9(Thieno3,2-bthiophene-2-carbaldehyde)
• 6030-36-0(4-Methylthiophene-2-carbaldehyde)
• 51925-22-5(Naphtho[1,2-b]thiophene-2-carboxaldehyde)
• 3541-37-5(1-benzothiophene-2-carbaldehyde)
• 13679-70-4(5-Methyl-2-thiophenecarboxaldehyde)
• 98-03-3(Thiophene-2-carbaldehyde)
• 30583-13-2(Thiophenecarboxaldehyde)
• 206768-21-0(5-Ethynylthiophene-2-carbaldehyde)
• 36880-33-8(5-Ethylthiophene-2-carbaldehyde)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)