Production Method 1

932-83-2

Reaction Conditions

1.1 Reagents: Sodium nitrite Catalysts: Hydrogen (T-4)-dioxobis[sulfato(2-)-κO]tungstate(2-) (2:1) Solvents: Dichloromethane ;  5 min, rt

Reference

Tungstate sulfuric acid (TSA)/NaNO2 as a novel heterogeneous system for the N-nitrosation of secondary amines under mild conditions

Karami, Bahador; Montazerozohori, Morteza; Habibi, Mohammad Hossein, Bulletin of the Korean Chemical Society, 2005, 26(7), 1125-1128

Production Method 2

932-83-2

Reaction Conditions

1.1 Reagents: Silica ,  Sodium nitrite ,  Trichloromelamine Solvents: Dichloromethane ,  Water ;  10 min, rt

Reference

Efficient procedure for chemoselective N-nitrosation of secondary amines with trichloromelamine-NaNO2

Bamoniri, A.; Zolfigol, M. A.; Mirjalili, B. F.; Fallah, F., Russian Journal of Organic Chemistry, 2007, 43(9), 1393-1396

Production Method 3

932-83-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Water Catalysts: Citric acid ,  Silica Solvents: Dichloromethane ;  50 min, rt

Reference

Chemoselective N-nitrosation of secondary amines under heterogeneous and mild conditions via in situ generation of HNO2

Ghorbani-Choghamarani, Arash; Goudarziafshar, Hamid; Rezaee, Somaieh; Mortazavi, Saiedeh Shima, Chinese Chemical Letters, 2009, 20(4), 415-419

Production Method 4

932-83-2

Reaction Conditions

1.1 Reagents: Perchloric acid (silica-gel-supported perchloric acid) ,  Sodium nitrite Solvents: Dichloromethane ;  5 min, rt

Reference

N-Nitrosation of Secondary Amines Using Supported Perchloric Acid on Silica Gel and Stereoselectivity Study of Nitroso Products

Goudarziafshar, Hamid; Ghorbani-Choghamarani, Arash; Hadian, Laila, Journal of the Chinese Chemical Society (Weinheim, 2013, 60(10), 1272-1276

Production Method 5

932-83-2

Reaction Conditions

1.1 Reagents: Sodium nitrite Catalysts: Methanesulfonic acid ,  Alumina Solvents: Dichloromethane ,  Water ;  10 min, rt

Reference

Alumina-methanesulfonic acid (AMA)/NaNO2 as an efficient procedure for the chemoselective N-nitrosation of secondary amines

Niknam, Khodabakhsh; Ali Zolfigol, Mohammad, Synthetic Communications, 2006, 36(16), 2311-2319

Production Method 6

932-83-2

Reaction Conditions

1.1 Reagents: Sodium nitrite Solvents: Acetonitrile ,  Water ;  4 h

Reference

Flow Electrochemistry for the N-Nitrosation of Secondary Amines

Ali, Rojan; Babaahmadi, Rasool; Didsbury, Matthew; Stephens, Rebecca; Melen, Rebecca L.; et al, Chemistry - A European Journal, 2023, 29(32),

Production Method 7

932-83-2

Reaction Conditions

1.1 Reagents: Sodium nitrite Solvents: Acetic acid ,  Water

Reference

Structural Features of Aliphatic N-Nitrosamines of 7-Azabicyclo[2.2.1]heptanes That Facilitate N-NO Bond Cleavage

Ohwada, Tomohiko; Miura, Motoko; Tanaka, Haruko; Sakamoto, Shigeru; Yamaguchi, Kentaro; et al, Journal of the American Chemical Society, 2001, 123(42), 10164-10172

Production Method 8

932-83-2

Reaction Conditions

1.1 Reagents: 1,4-Dinitro-1H-pyrazole Solvents: 1,1,1,3,3,3-Hexafluoro-2-propanol ;  16 h, 80 °C

Reference

Preparation of N-NO compounds

, China, , ,

Production Method 9

342620-00-2

932-83-2

Reaction Conditions

1.1 Catalysts: Ethyl nitrite

Reference

Generation of azidonium intermediates with the aid of N-aminoheterocycles

Keschmann, Ernst; Zbiral, Erich; Schweng, Josef, Justus Liebigs Annalen der Chemie, 1977, (9), 1508-15

Production Method 10

932-83-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water

Reference

Antidiabetic agents. N4-Arylsulfonylsemicarbazides

Wright, John B.; Willette, Robert W., Journal of Medicinal & Pharmaceutical Chemistry, 1962, 5, 815-22

Production Method 11

932-83-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Water ,  Molybdate(2-), dioxobis[sulfato(2-)-κO]-, hydrogen (1:2), (T-4)- Solvents: Dichloromethane ;  15 min, rt

Reference

Molybdate sulfuric acid/NaNO2. A novel heterogeneous system for the N-nitrosation of secondary amines under mild conditions

Montazerozohori, Morteza; Karami, Bahador, Helvetica Chimica Acta, 2006, 89(12), 2922-2926

Production Method 12

932-83-2

Reaction Conditions

1.1 Reagents: Silica ,  Sodium nitrite ,  Nafion H Solvents: Dichloromethane ,  Water ;  30 min, rt

Reference

The use of Nafion-H/NaNO2 as an efficient procedure for the chemoselective N-nitrosation of secondary amines under mild and heterogeneous conditions

Zolfigol, Mohammad Ali; Habibi, Davood; Mirjalili, BiBi Fatemeh; Bamoniri, Abdolhamid, Tetrahedron Letters, 2003, 44(16), 3345-3349

Production Method 13

932-83-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Dichloromethane ;  0 °C; 10 min, pH 1 - 2, rt
1.2 Reagents: Water ;  0 °C

Reference

Visible-Light-Promoted Photoaddition of N-Nitrosopiperidines to Alkynes: Continuous Flow Chemistry Approach to Tetrahydroimidazo[1,2-a]pyridine 1-Oxides

Patil, Dilip V. ; Lee, Yulim; Kim, Hun Young ; Oh, Kyungsoo, Organic Letters, 2022, 24(31), 5840-5844

Production Method 14

932-83-2

Reaction Conditions

1.1 Reagents: Silica ,  Sodium nitrite ,  Molybdenum phosphorus hydroxide oxide Solvents: Dichloromethane ;  10 min, rt

Reference

Molybdatophosphoric acid/NaNO2 as an efficient procedure for the chemoselective N-nitrosation of secondary amines

Zolfigol, Mohammad Ali; Niknam, Khodabakhsh; Nazari, Fariba, Journal of the Chinese Chemical Society (Taipei, 2006, 53(3), 669-676

Production Method 15

932-83-2

Reaction Conditions

1.1 Reagents: 1,3-Dibromo-5,5-dimethylhydantoin ,  Sodium nitrite Catalysts: Silica Solvents: Dichloromethane ,  Water ;  7 min, rt

Reference

1,3-Dihalo-5,5-dimethylhydantoin/NaNO2 as an efficient heterogeneous system for the N-nitrosation of N,N-dialkylamines under mild conditions

Niknam, K.; Zolfigol, M. A., Journal of the Iranian Chemical Society, 2006, 3(1), 59-63

Production Method 16

932-83-2

Reaction Conditions

1.1 Reagents: Tetrabutylammonium tetrafluoroborate ,  Potassium nitrite Solvents: Dichloromethane ;  4 h, rt

Reference

The Use of Potassium/Sodium Nitrite as a Nitrosating Agent in the Electrooxidative N-Nitrosation of Secondary Amines

Wang, Ying; You, Shiqi; Ruan, Mengyao; Wang, Feiyi; Ma, Chao; et al, European Journal of Organic Chemistry, 2021, 2021(22), 3289-3293

Production Method 17

932-83-2

Reaction Conditions

1.1 Reagents: p-Toluenesulfonic acid ,  Sodium nitrite Solvents: Dichloromethane ;  0 °C; 1 h, rt

Reference

Preparation method for deuterated compounds

, World Intellectual Property Organization, , ,

Production Method 18

932-83-2

Reaction Conditions

Reference

Nucleophilic α-sec-aminoalkylation: 2-(diphenylhydroxymethyl)pyrrolidine. (2-Pyrrolidinemethanol, α,α-diphenyl-)

Enders, D.; Pieter, R.; Renger, B.; Seebach, D., Organic Syntheses, 1978, 58, 113-22

Production Method 19

932-83-2

Reaction Conditions

Reference

Transnitrosation by aliphatic nitrosomines

Singer, Sandra S.; Lijinsky, William; Singer, George M., Tetrahedron Letters, 1977, (19), 1613-16

Production Method 20

932-83-2

Reaction Conditions

Reference

Synthesis of amino derivatives of some nitrogen-containing heterocycles

Sladkova, T. A.; Chernyshev, E. A., Khimiya Geterotsiklicheskikh Soedinenii, 1968, (1), 140-1

N-Nitrosohexamethylenimine Raw materials

• 1H-Azepin-1-amine, N-(bromotriphenylphosphoranyl)hexahydro-

N-Nitrosohexamethylenimine Preparation Products

• N-Nitrosohexamethylenimine (932-83-2)

• 1. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azepanes Azepanes
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azepanes

• 20917-49-1(N-Nitrosoheptamethyleneimine)
• 13256-06-9(N,N-Diamylnitrosamine)
• 4549-44-4(N-Nitroso-N-ethylbutylamine)
• 100-75-4(N-Nitrosopiperidine)
• 930-55-2(1-Nitrosopyrrolidine)
• 54528-00-6(3-Amino-3-azabicyclo3,3,0octane)
• 6949-28-6(N-Nitroso-di-N-hexylamine)
• 13256-07-0(N-Amyl-N-methylnitrosamine)
• 7068-83-9(N-Butyl-N-methylnitrosamine)
• 98648-34-1(N-Methyl-N-nitroso-1-hexadecylamine)