Production Method 1

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Methanol ;  3 atm, 45 - 50 °C

Reference

Process for preparation of 3-(1-piperidinyl methyl) phenol as intermediate of roxatidine acetate hydrochloride

, China, , ,

Production Method 2

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Iron ,  Ammonium chloride Solvents: Methanol ,  Water ;  45 min, reflux

Reference

Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3(2H)-isoquinolones as CDK inhibitors and their preparation, pharmaceutical composition and use in the treatment of cancer, infections and other diseases

, World Intellectual Property Organization, , ,

Production Method 3

77201-13-9

93138-55-7

Reaction Conditions

1.1 Reagents: Magnesium ,  Titanium tetrachloride Solvents: Tetrahydrofuran ;  0 °C; 2 h, rt
1.2 Solvents: Tetrahydrofuran ;  rt; rt → 0 °C
1.3 Reagents: Sodium bicarbonate ,  Sodium hydroxide Solvents: Water ;  pH 9, 0 °C

Reference

A Convenient and General Reduction of Amides to Amines with Low-Valent Titanium

Zhang, Tongxin; Zhang, Yan; Zhang, Weixi; Luo, Meiming, Advanced Synthesis & Catalysis, 2013, 355(14-15), 2775-2780

Production Method 4

99-61-6

93138-55-7

Reaction Conditions

1.1 Reagents: Dimethylamine ,  Hydrogen Catalysts: Palladium Solvents: 1,4-Dioxane ;  18 h, rt; 10 h, rt

Reference

An improved method for the synthesis of 2-, 3- and 4-dialkylaminomethylanilines

Pete, Bela; Szantay, Csaba, ARKIVOC (Gainesville, 2008, (6), 78-83

Production Method 5

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Stannous chloride Solvents: Ethanol ;  3 h, rt → reflux

Reference

Aromatic and heterocyclic compounds as SOX11 inhibitors for treating mantle cell lymphoma and their preparation

, World Intellectual Property Organization, , ,

Production Method 6

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Palladium Solvents: Ethanol ;  rt; heated; 15 min, rt

Reference

Preparation of indole amino acid derivatives as somatostatin agonists or antagonists

, World Intellectual Property Organization, , ,

Production Method 7

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  24 h, rt

Reference

Preparation of benzoxepinecarboxamides, benzocycloheptenecarboxamides, naphthalenecarboxamides, and related compounds as CCR5 antagonists.

, World Intellectual Property Organization, , ,

Production Method 8

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Nickel Solvents: Ethanol ,  Tetrahydrofuran ;  30 - 60 min, rt

Reference

Preparation of hydrazonodiaminopyrazoles with antiproliferative activity.

, United States, , ,

Production Method 9

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Hydrazine hydrate (1:1) Catalysts: Nickel Solvents: Ethanol ,  Tetrahydrofuran ;  15 min, rt

Reference

Preparation of hydrazonodiaminopyrazoles as integrin-linked kinase inhibitors with antiproliferative activity.

, World Intellectual Property Organization, , ,

Production Method 10

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Iron ,  Ammonium chloride Solvents: Methanol ,  Water ;  1 h, reflux

Reference

Combination of 4-anilinoquinazoline, arylurea and tertiary amine moiety to discover novel anticancer agents

Zuo, Sai-Jie; Zhang, Sai; Mao, Shuai; Xie, Xiao-Xiao; Xiao, Xue; et al, Bioorganic & Medicinal Chemistry, 2016, 24(2), 179-190

Production Method 11

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Iron ,  Ammonium chloride Solvents: Methanol ,  Water ;  45 min, reflux

Reference

Substituted isoquinoline-1,3(2H,4H)-diones, 1-thioxo-1,4-dihydro-2H-isoquinoline-3-ones and 1,4-dihydro-3(2H)-isoquinolones as CDK inhibitors and their preparation, pharmaceutical composition and use in the treatment of cancer

, United States, , ,

Production Method 12

59507-46-9

93138-55-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  24 h, rt

Reference

Preparation of benzoxepinecarboxamides, benzocycloheptenecarboxamides, naphthalenecarboxamides, and related compounds as MCP-1 receptor antagonists.

, World Intellectual Property Organization, , ,

Production Method 13

93138-55-7

Reaction Conditions

Reference

Quinolone carboxylic acid derivatives for treatment of hyperproliferative conditions, their preparation and pharmaceutical compositions

, World Intellectual Property Organization, , ,

3-(piperidin-1-yl)methylaniline Raw materials

• 3-Nitrobenzaldehyde
• 1-(3-nitrophenyl)methylpiperidine
• (3-Aminophenyl)-1-piperidinyl-methanone

3-(piperidin-1-yl)methylaniline Preparation Products

• 3-(piperidin-1-yl)methylaniline (93138-55-7)

• 1. An investigation on the interaction modes of a single-strand DNA aptamer and RBP4 protein: a molecular dynamic simulations approach?
  Raheleh Torabi,Hedayatollah Ghourchian,Massoud Amanlou Org. Biomol. Chem., 2016,14, 8141-8153
• 2. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 3. An anti-leakage liquid metal thermal interface material
  Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
• 4. Aggregation, pretransitional behavior, and optical properties in the isotropic phase of lyotropic chromonic liquid crystals studied in high magnetic fields
  Tanya Ostapenko,Peter J. Collings,Samuel N. Sprunt,J. T. Gleeson Soft Matter, 2013,9, 9487-9498
• 5. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines N-benzylpiperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Benzylpiperidines N-benzylpiperidines
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

• 18074-84-5(Benzenamine, N-methyl-4-(1-piperidinylmethyl)-)
• 919018-27-2(3-(3-Methyl-1-piperidinyl)methylaniline)
• 262368-64-9(4-[(4-methylpiperidin-1-yl)methyl]aniline)
• 328289-91-4(Benzenamine, 4-[(2,6-dimethyl-1-piperidinyl)methyl]-)
• 64097-52-5(Benzenamine,N-phenyl-4-(1-piperidinylmethyl)-)
• 859850-65-0(N-methyl-N-(3-piperidin-1-ylbenzyl)amine)
• 937669-68-6(3-(2-methyl-1-piperidinyl)methylaniline)
• 29608-05-7(4-[(piperidin-1-yl)methyl]aniline)
• 183365-31-3(3-(Pyrrolidin-1-ylmethyl)aniline)
• 916739-30-5(4-(1-PIPERIDINYLMETHYL)-BENZENAMINE DIHYDROCHLORIDE)