Production Method 1

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Tetrahydrofuran ;  reflux

Reference

Probing the Delicate Balance between Pauli Repulsion and London Dispersion with Triphenylmethyl Derivatives

Roesel, Soeren; Becker, Jonathan; Allen, Wesley D.; Schreiner, Peter R., Journal of the American Chemical Society, 2018, 140(43), 14421-14432

Production Method 2

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Tetrahydrofuran ;  rt

Reference

Mechanochemistry-Amended Barbier Reaction as an Expedient Alternative to Grignard Synthesis

Varma Nallaparaju, Jagadeesh ; Nikonovich, Tatsiana ; Jarg, Tatsiana ; Merzhyievskyi, Danylo ; Aav, Riina ; et al, Angewandte Chemie, 2023, 62(39),

Production Method 3

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Diethyl ether ,  Tetrahydrofuran ;  rt; rt → 50 °C

Reference

Enantioselective Synthesis of Chiral Cyclic Hydrazines by Ni-Catalyzed Asymmetric Hydrogenation

Wang, Siwei; Xie, Chaochao; Zhu, Yu; Zi, Guofu ; Zhang, Zhanbin; et al, Organic Letters, 2023, 25(20), 3644-3648

Production Method 4

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Diethyl ether ;  rt → reflux; 30 min, reflux; 1 h, reflux

Reference

Rhodium-Catalyzed Intramolecular Cyclopropanation of Trifluoromethyl- and Pentafluorosulfanyl-Substituted Allylic Cyanodiazoacetates

Peyrical, Lauriane C. ; Berger, Marie-Rose Ouellet-Du; Boucher, Maxim; Birepinte, Melodie; Paquin, Jean-Francois ; et al, Organic Letters, 2023, 25(14), 2487-2491

Production Method 5

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: 1,2-Dibromoethane ,  Magnesium Solvents: Tetrahydrofuran ;  heated
1.2 Solvents: Tetrahydrofuran ;  heated; 1 h, rt

Reference

A Sulfoxide Reagent for One-Pot, Three-Component Syntheses of Sulfoxides and Sulfinamides

Saito, Fumito, Angewandte Chemie, 2022, 61(52),

Production Method 6

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ;  rt; 20 min, reflux; 6 h, reflux

Reference

Enantioselective Construction of Sila-bicyclo[3.2.1] Scaffolds Bearing Both Carbon- and Silicon-Stereocenters

Yin, Kai-Lin; Zhao, Shuang; Qin, Ying; Chen, Shu-Han; Li, Bo; et al, ACS Catalysis, 2022, 12(22), 13999-14005

Production Method 7

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: 1,2-Dibromoethane Solvents: Tetrahydrofuran ;  heated; 1 h, rt

Reference

A sulfoxide reagent for one-pot, three-component syntheses of sulfoxides and sulfinamides

Saito, Fumito, ChemRxiv, 2022, 1, 1-11

Production Method 8

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ;  rt; 1 min, rt
1.2 Reagents: Water

Reference

Stereospecific Csp3 Suzuki-Miyaura Cross-Coupling That Evades β-Oxygen Elimination

LaPorte, Antonio J. ; Shi, Yao; Hein, Jason E. ; Burke, Martin D., ACS Catalysis, 2022, 12(17), 10905-10912

Production Method 9

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: 1,2-Dibromoethane Solvents: Tetrahydrofuran ;  1.5 h, rt
1.2 Solvents: Tetrahydrofuran ;  1 h, rt; 2 h, rt

Reference

Synthesis of 1- and 1,2-Substituted Cyclopropylamines from Ketone Homoenolates

West, Michael S.; Pia, Julia E.; Rousseaux, Sophie A. L., Organic Letters, 2022, 24(32), 5869-5873

Production Method 10

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Tetrahydrofuran ;  rt; rt → 50 °C

Reference

Nickel-Catalyzed Asymmetric Hydrogenation of γ-Keto Acids, Esters, and Amides to Chiral γ-Lactones and γ-Hydroxy Acid Derivatives

Xiao, Guiying; Xie, Chaochao; Guo, Qianling; Zi, Guofu ; Hou, Guohua ; et al, Organic Letters, 2022, 24(14), 2722-2727

Production Method 11

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Solvents: 1,2-Dibromoethane ,  Tetrahydrofuran ;  rt; 1 h, 40 °C

Reference

Asymmetric Synthesis of Chiral Sulfimides through the O-Alkylation of Enantioenriched Sulfinamides and Addition of Carbon Nucleophiles

Tsuzuki, Saori; Kano, Taichi, Angewandte Chemie, 2023, 62(16),

Production Method 12

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ;  rt; 3 h, rt

Reference

Synthesis of Sulfur-Containing Oxindoles by Photoinduced Alkene Difunctionalization via Sulfur 1,2-Relocation

Lu, Cong; Chen, Rui; Wang, Rui; Jing, Dong; Zheng, Ke, Organic Letters, 2023, 25(5), 750-755

Production Method 13

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Solvents: Tetrahydrofuran

Reference

The comparison of self-assembling behaviour of phenyl biphenylcarboxylate and biphenyl benzoate compounds with the different length and shape of chiral terminal chain

Strojwas, Katarzyna; Dabrowski, Roman; Drzewinski, Witold; Szarek, Michal; Bubnov, Alexej; et al, Journal of Molecular Liquids, 2023, 369,

Production Method 14

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine Solvents: Tetrahydrofuran ;  heated; 10 °C; overnight, rt

Reference

Iron-Catalyzed Cross-Coupling of Thioesters and Organomanganese Reagents

Geiger, Valentin Jacob ; Lefevre, Guillaume; Fleischer, Ivana, Chemistry - A European Journal, 2022, 28(62),

Production Method 15

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium

Reference

Visible light-induced N-radical 5-exo/6-endo cyclization of alkenyl amides: facile access to isoindolinones/isoquinolinones

Lei, Zhen-Yao; Hu, Kui; He, Yuan-Xiang; Geng, Shu; Chen, Li-Na; et al, Organic & Biomolecular Chemistry, 2022, 20(12), 2397-2401

Production Method 16

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine Solvents: Tetrahydrofuran ;  70 °C; 2 h, 70 °C

Reference

Method for preparing di(1-adamantyl) cycloalkylphosphine ligand by diborane treatment

, China, , ,

Production Method 17

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium

Reference

Clarification on the Reactivity of Diaryl Diselenides toward Hexacyclohexyldilead under Light

Hung, Vu Thai; Tran, Cong Chi; Yamamoto, Yuki; Kodama, Shintaro ; Nomoto, Akihiro ; et al, Molecules, 2021, 26(20),

Production Method 18

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium

Reference

Benzylamine derivatives prepared for skin lightening

, World Intellectual Property Organization, , ,

Production Method 19

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: Iodine Solvents: Tetrahydrofuran ;  heated; 1 - 2 h, heated

Reference

A facile and practical preparation of P-chiral phosphine oxides

Xu, Ronghua; Gao, Zhenhua; Yu, Yiteng; Tang, Yehua; Tian, Duanshuai; et al, Chemical Communications (Cambridge, 2021, 57(27), 3335-3338

Production Method 20

108-85-0

931-50-0

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine Solvents: Diethyl ether ;  rt; rt → reflux; 30 h, reflux

Reference

Degradable photoresist resin monomer from trimethylbicyclo[2.2.2]octanedione and synthesis method thereof

, China, , ,

Cyclohexylmagnesium Bromide (~1.0 M in THF) Raw materials

• Bromocyclohexane

Cyclohexylmagnesium Bromide (~1.0 M in THF) Preparation Products

• Cyclohexylmagnesium Bromide (~1.0 M in THF) (931-50-0)

• 1. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
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• Other Chemical Reagents Organic Metal Reagents

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)