Production Method 1

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: Carbon ;  3 h, 80 °C

Reference

Carbon-SO3Na Catalysed Synthesis of Glycerol Carbonate via Transesterification of Glycerol and Dimethyl Carbonate

Sandhya Rani, Gundabathini; Jyotsna, Adigopula; Prabhavathi Devi, Bethala L. A., ChemistrySelect, 2022, 7(47),

Production Method 2

556-52-5

931-40-8

Reaction Conditions

1.1 4 h, 20 bar, 90 °C

Reference

Halide aided synergistic ring opening mechanism of epoxides and their cycloaddition to CO2 using MCM-41-imidazolium bromide catalyst

Adam, Farook; Appaturi, Jimmy Nelson; Ng, Eng-Poh, Journal of Molecular Catalysis A: Chemical, 2014, 386, 42-48

Production Method 3

556-52-5

931-40-8

Reaction Conditions

1.1 Catalysts: Pentaerythritol ,  Tetrabutylammonium iodide ;  1 min, 4 bar, rt; rt → 70 °C; 16 h, 70 °C

Reference

Cycloaddition of carbon dioxide and epoxides using pentaerythritol and halides as dual catalyst system

Wilhelm, Michael E.; Anthofer, Michael H.; Cokoja, Mirza; Markovits, Iulius I. E.; Herrmann, Wolfgang A.; et al, ChemSusChem, 2014, 7(5), 1357-1360

Production Method 4

556-52-5

931-40-8

Reaction Conditions

1.1 Catalysts: Aluminum(1+), ethyl[N,N,N-tributyl-3-[[[2-[[[5-(1,1-dimethylethyl)-2-(hydroxy-κO… ;  5 h, 1 MPa, 120 °C

Reference

Method for preparing highly active bifunctional catalyst for reaction of carbon dioxide and epoxy alkane to prepare cyclic carbonate and its application

, China, , ,

Production Method 5

56-81-5

931-40-8

Reaction Conditions

1.1 4 h, 70 - 100 °C

Reference

Method for preparing glycerol carbonate from biodiesel based glycerol and dimethyl carbonate

, China, , ,

Production Method 6

56-81-5

931-40-8

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Oxygen Catalysts: Selenium Solvents: Dimethylformamide ;  24 h, 0.1 MPa, 20 °C

Reference

Facile synthesis of glycerol carbonate from glycerol using selenium-catalyzed carbonylation with carbon monoxide

Mizuno, Takumi; Nakai, Takeo; Mihara, Masatoshi, Heteroatom Chemistry, 2010, 21(7), 541-545

Production Method 7

530-62-1

56-81-5

931-40-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  rt → 0 °C
1.2 rt → 40 °C; 10 min, 40 °C; 40 °C → rt
1.3 Reagents: Hydrogen ion Solvents: Water ;  pH 7.0, rt

Reference

Process for manufacturing of glycerin carbonate

, Brazil, , ,

Production Method 8

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: 1H-Imidazolium, 3-butyl-2-carboxy-1-methyl-, inner salt Solvents: Water ;  80 min, 74 °C

Reference

Imidazolium-2-carboxylate as an efficient, expeditious and eco-friendly organocatalyst for glycerol carbonate synthesis

Naik, Prashant U.; Petitjean, Laetitia; Refes, Karima; Picquet, Michel; Plasseraud, Laurent, Advanced Synthesis & Catalysis, 2009, 351, 1753-1756

Production Method 9

556-52-5

931-40-8

Reaction Conditions

1.1 Catalysts: Zinc, dibromobis(1,3,5,7-tetraazatricyclo[3.3.1.13,7]decane-N1)-, (T-4)- ;  12 h, 1.5 MPa, 60 °C

Reference

Hexamethylenetetramine Complexes as Easy-to-Handle and Efficient Lewis Acid-Base Heterogeneous Catalysts for Coupling of CO2 under Mild Conditions

Lan, Dong-Hui; Chen, Kun; Zhu, Heng-Jun; Shen, Jing; Wu, Shui-Sheng; et al, Industrial & Engineering Chemistry Research, 2022, 61(31), 11390-11396

Production Method 10

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: 1-Butyl-3-methylimidazolium hydrogen carbonate ;  rt → 65 °C; 1.5 h, 65 °C

Reference

Application of dialkylimidazolium bicarbonate as catalyst in catalytic synthesis of glycerol carbonate

, China, , ,

Production Method 11

556-52-5

931-40-8

Reaction Conditions

1.1 Catalysts: Tetrabutylammonium iodide ,  2279076-92-3 ;  10 bar, 25 °C → 120 °C; 18 h, 120 °C

Reference

New zinc/tetradentate N4 ligand complexes: Efficient catalysts for solvent-free preparation of cyclic carbonates by CO2/epoxide coupling

Karame, Iyad; Zaher, Samira; Eid, Nadim ; Christ, Lorraine, Molecular Catalysis, 2018, 456, 87-95

Production Method 12

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: Trisodium phosphate ;  60 min, 70 °C

Reference

Glycerol carbonate synthesis from glycerol and dimethyl carbonate using trisodium phosphate

Okoye, P. U.; Abdullah, A. Z.; Hameed, B. H., Journal of the Taiwan Institute of Chemical Engineers, 2016, 68, 51-58

Production Method 13

556-52-5

931-40-8

Reaction Conditions

1.1 Catalysts: 1H-Imidazolium, 3-(2-chloroethyl)-1-[3-(trihydroxysilyl)propyl]-, chloride (1:1) (MCM-41 supported) ;  4 h, 20 bar, 90 °C

Reference

Solid imidazolium halide catalysts for the solvent-free synthesis of glycerol carbonate

Appaturi, Jimmy Nelson; Ng, Eng-Poh; Adam, Farook, Journal of CO2 Utilization, 2014, 6, 69-74

Production Method 14

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: Calcium magnesium oxide (Ca0.8Mg1.2O2) ;  90 min, 70 °C

Reference

Mg1+xCa1-xO2 as reusable and efficient heterogeneous catalyst for the synthesis of glycerol carbonate via the transesterification of glycerol with dimethyl carbonate

Khayoon, M. S.; Hameed, B. H., Applied Catalysis, 2013, 466, 272-281

Production Method 15

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: Mg Al Hydrotalcite (anion-exchanged) ;  6 h, 403 K

Reference

Tunable basic and textural properties of hydrotalcite derived materials for transesterification of glycerol

Alvarez, M. G.; Chimentao, R. J.; Figueras, F.; Medina, F., Applied Clay Science, 2012, 58, 16-24

Production Method 16

556-52-5

931-40-8

Reaction Conditions

1.1 Reagents: Tetrabutylammonium bromide Catalysts: Stereoisomer of bis[[4,4′-[(1R,2R)-1,2-cyclohexanediyldi(nitrilo-κN)]bis[2-penta… ;  24 h, 1 atm, 26 °C

Reference

Bimetallic aluminium(acen) complexes as catalysts for the synthesis of cyclic carbonates from carbon dioxide and epoxides

North, Michael; Young, Carl, Catalysis Science & Technology, 2011, 1(1), 93-99

Production Method 17

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: Aluminate (Al(OH)63-), (OC-6-11)-, magnesium carbonate hydroxide (2:5:1:2) Solvents: Dimethylformamide ;  2 h, 100 °C

Reference

Method for preparation of glycerin carbonate

, Japan, , ,

Production Method 18

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: Potassium carbonate ;  5 h, 71 - 76 °C

Reference

Synthesis of glycerol carbonate from glycerol, a by-product of biodiesel production

Herseczki, Zsanett; Varga, Tamas; Marton, Gyula, International Journal of Chemical Reactor Engineering, 2009, 7,

Production Method 19

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: Stereoisomer of octabutyldi-μ-chlorodichlorodi-μ3-oxotetratin ;  2 h, 100 °C; 100 °C → rt

Reference

Effect of lipophilicity of catalyst in cyclic carbonate formation by transesterification of polyhydric alcohols

Patel, Yogesh; George, Jimil; Pillai, S. Muthukumaru; Munshi, Pradip, Green Chemistry, 2009, 11(7), 1056-1060

Production Method 20

56-81-5

931-40-8

Reaction Conditions

1.1 Catalysts: Dabco ;  16 h, 75 °C

Reference

Carbonate couplers and functional cyclic carbonates from amino acids and glucosamine

Fricke, Nicole; Keul, Helmut; Moeller, Martin, Macromolecular Chemistry and Physics, 2009, 210(3-4), 242-255

4-(Hydroxymethyl)-1,3-dioxolan-2-one Raw materials

• Glycidol Standard
• N,N'-Carbonyldiimidazole
• Glycerol

4-(Hydroxymethyl)-1,3-dioxolan-2-one Preparation Products

• 4-(Hydroxymethyl)-1,3-dioxolan-2-one (931-40-8)

• 1. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 2. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 5. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Organic carbonic acids and derivatives Carbonic acid diesters
• Material Chemicals Electrical Materials Biosensor Materials
• Material Chemicals Electrical Materials

Recent Advances in the Application of 4-(Hydroxymethyl)-1,3-dioxolan-2-one (CAS: 931-40-8) in Chemical Biology and Pharmaceutical Research

4-(Hydroxymethyl)-1,3-dioxolan-2-one (CAS: 931-40-8), a cyclic carbonate derivative, has recently garnered significant attention in chemical biology and pharmaceutical research due to its versatile reactivity and potential applications in drug delivery, polymer chemistry, and biocatalysis. This compound, characterized by its hydroxymethyl and cyclic carbonate functionalities, serves as a key intermediate in the synthesis of various bioactive molecules and functional materials. Recent studies have explored its utility in developing novel drug carriers, biodegradable polymers, and enzyme inhibitors, highlighting its broad applicability in the life sciences.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the use of 4-(Hydroxymethyl)-1,3-dioxolan-2-one as a building block for pH-responsive drug delivery systems. Researchers synthesized a series of polymer-drug conjugates, leveraging the compound's ability to undergo controlled hydrolysis under acidic conditions, mimicking the tumor microenvironment. The study reported enhanced drug release kinetics and improved therapeutic efficacy in preclinical models of breast cancer, suggesting its potential for targeted cancer therapy.

In the field of biocatalysis, a recent breakthrough published in ACS Catalysis (2024) highlighted the compound's role as a substrate for engineered carbonic anhydrases. The study revealed that 4-(Hydroxymethyl)-1,3-dioxolan-2-one could be selectively transformed into valuable chiral intermediates with high enantioselectivity (up to 99% ee) using optimized enzyme variants. This finding opens new avenues for sustainable synthesis of optically active pharmaceuticals, aligning with the growing demand for green chemistry approaches in drug manufacturing.

Material science applications have also benefited from recent advancements involving this compound. A 2024 Nature Communications paper described its incorporation into self-healing polycarbonate networks, where the hydroxymethyl group facilitated dynamic covalent bonding. The resulting materials exhibited remarkable mechanical properties and autonomous repair capabilities at physiological temperatures, making them promising candidates for medical implants and tissue engineering scaffolds.

From a safety and pharmacokinetics perspective, recent toxicological studies (2023, Regulatory Toxicology and Pharmacology) have provided comprehensive data on 4-(Hydroxymethyl)-1,3-dioxolan-2-one, establishing its favorable safety profile at therapeutic doses. Metabolic studies using radiolabeled compounds demonstrated rapid clearance and minimal tissue accumulation, addressing previous concerns about potential bioaccumulation of cyclic carbonate derivatives.

Looking forward, the unique chemical properties of 4-(Hydroxymethyl)-1,3-dioxolan-2-one continue to inspire innovative applications across multiple disciplines. Current research directions include its exploration as a covalent warhead in targeted protein degradation strategies and as a modular component in mRNA vaccine delivery systems. The compound's versatility and the growing body of research supporting its utility suggest it will remain an important focus of chemical biology and pharmaceutical research in the coming years.

• 823838-60-4(Carbonic acid, 2-hydroxy-1-(methoxymethyl)ethyl methyl ester)
• 84137-71-3(1,3-Dioxolan-2-one, 4-[(1-methylethoxy)methyl]-)
• 185836-34-4((R)-(+)-4-(Methoxymethyl)-1,3-dioxolan-2-one)
• 51260-39-0((S)-(-)-Propylene Carbonate)
• 135682-18-7((S)-(-)-4-(Methoxymethyl)-1,3-dioxolan-2-one)
• 16606-55-6((R)-1,2-Propylene Carbonate)
• 108-32-7(Propylene carbonate)
• 76913-29-6(Carbonic acid, methyl (2-oxo-1,3-dioxolan-4-yl)methyl ester)
• 202480-74-8(1,2-Propylene-d6 Carbonate)
• 64057-77-8(2-Propanol,1,3-bis(1-methylethoxy)-, carbonate (2:1) (9CI))