Production Method 1

93-37-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Trifluoroacetic acid ,  2,4,6-Trimethylpyridine ,  Palladium diacetate Solvents: Ethanol ;  16 h, 150 °C

Reference

Assembly of Diversely Substituted Quinolines via Aerobic Oxidative Aromatization from Simple Alcohols and Anilines

Li, Jixing; Zhang, Jinlong; Yang, Huameng; Jiang, Gaoxi, Journal of Organic Chemistry, 2017, 82(6), 3284-3290

Production Method 2

93-37-8

Reaction Conditions

1.1 Catalysts: Gold (titania-containing nanoparticles) ,  Titania (gold-containing nanoparticles) ;  5 h, 30 °C

Reference

One-pot photocatalytic synthesis of quinaldines from nitroarenes with Au loaded TiO2 nanoparticles

Selvam, K.; Swaminathan, M., Catalysis Communications, 2011, 12(6), 389-393

Production Method 3

93-37-8

Reaction Conditions

1.1 Catalysts: Titania ,  Atomic nitrogen ;  4 h, 30 °C

Reference

Facile Synthesis of 2-Methylquinolines From Anilines on Mesoporous N-Doped TiO2 Under UV and Visible Light

Selvam, K.; Swaminathan, M., Synthesis and Reactivity in Inorganic, 2013, 43(4), 500-508

Production Method 4

2215845-42-2

93-37-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Sodium thiosulfate ,  5,6-Bis(5-methoxy-2-thienyl)-2,3-pyrazinedicarbonitrile Solvents: Chloroform ,  Toluene ;  5 - 15 h, 25 °C
1.2 Reagents: Oxygen Catalysts: N-Hydroxytetrachlorophthalimide ,  5,6-Bis(5-methoxy-2-thienyl)-2,3-pyrazinedicarbonitrile Solvents: Acetonitrile ,  Dimethylacetamide ;  3 - 5 h, 25 °C

Reference

Sequential Photoredox Catalysis for Cascade Aerobic Decarboxylative Povarov and Oxidative Dehydrogenation Reactions of N-Aryl α-Amino Acids

Shao, Tianju; Yin, Yanli; Lee, Richmond; Zhao, Xiaowei; Chai, Guobi; et al, Advanced Synthesis & Catalysis, 2018, 360(9), 1754-1760

Production Method 5

93-37-8

Reaction Conditions

1.1 Catalysts: Palladium chloride Solvents: Acetonitrile ;  24 h, 80 °C

Reference

Preparation of pyrazolopyridines, pyrazolopyrimidines and related compounds for inhibiting plasma kallikrein

, United States, , ,

Production Method 6

93-37-8

Reaction Conditions

Reference

The rhodium complex-catalyzed synthesis of quinolines from aminoarenes and aliphatic aldehydes

Watanabe, Yoshihisa; Shim, Sang Chul; Mitsudo, Takeaki, Bulletin of the Chemical Society of Japan, 1981, 54(11), 3460-5

Production Method 7

93-37-8

Reaction Conditions

Reference

2-Methylquinolines

, Japan, , ,

Production Method 8

93-37-8

Reaction Conditions

1.1 Reagents: Sodium dodecyl sulfate Catalysts: 12-Molybdophosphoric acid Solvents: Toluene ,  Water ;  1 h, 80 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  basified

Reference

Micellar-Mediated Phosphomolybdic Acid: Highly Effective Reusable Catalyst for Synthesis of Quinoline and Its Derivatives

Chaskar, Atul; Padalkar, Vikas; Phatangare, Kiran; Langi, Bhushan; Shah, Chetan, Synthetic Communications, 2010, 40(15), 2336-2340

Production Method 9

93-37-8

Reaction Conditions

1.1 Catalysts: Palladium (nanoparticle complex with magnetite and graphene oxide) Solvents: Acetonitrile ;  8.5 h, 80 °C

Reference

Magnetically separable palladium-graphene nanocomposite as heterogeneous catalyst for the synthesis of 2-alkylquinolines via one pot reaction of anilines with alkenyl ethers

Verma, Sanny; Verma, Deepak; Jain, Suman L., Tetrahedron Letters, 2014, 55(15), 2406-2409

Production Method 10

93-37-8

Reaction Conditions

1.1 Catalysts: Ferric chloride hexahydrate Solvents: Carbon tetrachloride ;  2 h, 140 °C; 140 °C → 20 °C
1.2 Reagents: Sodium carbonate Solvents: Water ;  0.5 - 1 h, neutralized

Reference

Synthesis of substituted quinolines by the reaction of anilines with alcohols and CCl4 in the presence of Fe-containing catalysts

Khusnutdinov, R. I.; Bayguzina, A. R.; Aminov, R. I., Russian Chemical Bulletin, 2013, 62(1), 133-137

Production Method 11

93-37-8

Reaction Conditions

1.1 Solvents: Ethanol ;  5 h, 30 °C

Reference

Nano N-TiO2 mediated selective photocatalytic synthesis of quinaldines from nitrobenzenes

Selvam, Kaliyamoorthy; Swaminathan, Meenakshisundaram, RSC Advances, 2012, 2(7), 2848-2855

Production Method 12

93-37-8

Reaction Conditions

1.1 Catalysts: Titania (Au-doped) ;  4 h, heated; 30 min, 30 ± 1 °C

Reference

Au-doped TiO2 nanoparticles for selective photocatalytic synthesis of quinaldines from anilines in ethanol

Selvam, K.; Swaminathan, M., Tetrahedron Letters, 2010, 51(37), 4911-4914

Production Method 13

93-37-8

Reaction Conditions

1.1 Catalysts: Platinum ,  Titania Solvents: Ethanol ;  5 h, 30 °C

Reference

Novel redox photocatalyst Pt-TiO2 for the synthesis of 2-methylquinolines from nitroarenes

Selvam, Kaliyamoorthy; Swaminathan, Meenakshisundaram, Bulletin of the Chemical Society of Japan, 2011, 84(9), 953-959

Production Method 14

93-37-8

Reaction Conditions

1.1 Catalysts: Silver ,  Titania Solvents: Ethanol ;  3 h, 30 °C

Reference

Cost effective one-pot photocatalytic synthesis of quinaldines from nitroarenes by silver loaded TiO2

Selvam, K.; Swaminathan, M., Journal of Molecular Catalysis A: Chemical, 2011, 351, 52-61

Production Method 15

93-37-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: p-Toluenesulfonic acid ,  Pyridine ,  Palladium chloride ;  16 h, 150 °C

Reference

Preparation method of quinoline derivatives

, China, , ,

Production Method 16

78782-17-9

93-37-8

Reaction Conditions

1.1 Reagents: Dimethylzinc ,  Lithium tert-butoxide Solvents: Toluene ;  3 h, 120 °C

Reference

ZnMe2-Mediated, Direct Alkylation of Electron-Deficient N-Heteroarenes with 1,1-Diborylalkanes: Scope and Mechanism

Jo, Woohyun; Baek, Seung-yeol; Hwang, Chiwon; Heo, Joon; Baik, Mu-Hyun ; et al, Journal of the American Chemical Society, 2020, 142(30), 13235-13245

Production Method 17

537-92-8

93-37-8

Reaction Conditions

1.1 Reagents: Cupric acetate Catalysts: Silver hexafluoroantimonate ,  Bis(dichloro(η6-p-cymene)ruthenium) Solvents: 1,4-Dioxane ;  20 h, 140 °C

Reference

Carboxylate-assisted ruthenium(II)-catalyzed C-H activations of monodentate amides with conjugated alkenes

Li, Jie; Ackermann, Lutz, Organic Chemistry Frontiers, 2015, 2(9), 1035-1039

Production Method 18

93-37-8

Reaction Conditions

Reference

Orientation effects in the synthesis of quinoline derivatives

Osborne, A. G., Tetrahedron, 1983, 39(17), 2831-41

Production Method 19

93-37-8

Reaction Conditions

Reference

Preparation of benzazole derivatives for treating allergy disorders

, Japan, , ,

Production Method 20

93-37-8

Reaction Conditions

Reference

Thermolysis of polyazapentadienes. Part 7. An unambiguous route to 7-substituted quinolines from cinnamaldehyde derivatives

Hickson, Clare L.; McNab, Hamish, Journal of the Chemical Society, 1984, (7), 1569-72

2,7-Dimethylquinoline Raw materials

• 3-Acetylaminotoluene
• Bis[(pinacolato)boryl]methane
• 2-m-Tolylamino propionic acid

2,7-Dimethylquinoline Preparation Products

• 2,7-Dimethylquinoline (93-37-8)

• 1. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 2. Distinct impact of glycation towards the aggregation and toxicity of murine and human amyloid-β?
  Eunju Nam,Jiyeon Han,Sunhee Choi,Mi Hee Lim Chem. Commun., 2021,57, 7637-7640
• 3. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 4. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 5. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives

• 877-43-0(2,6-Dimethylquinoline)
• 1196-79-8(2,5-Dimethyl-1H-indole)
• 2243-89-2(2,4,6-trimethylquinoline)
• 72681-37-9(2,6,7-Trimethylquinoline)
• 5649-36-5(2,6-Dimethyl-1H-indole)
• 71633-43-7(Quinoline,2,4,7-trimethyl-)
• 27323-28-0(1H-Indole, methyl-)
• 1198-37-4(2,4-Dimethylquinoline)
• 155136-72-4(6H-Pyrido[3,2-b]carbazole,2,4-dimethyl-)
• 72681-40-4(Quinoline, 2,4,6,7-tetramethyl-)