• 1. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 2. Examination of deposit in commercial diluted phosphoric acid
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• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
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• 4. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines Pyrrolopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines

Comprehensive Overview of tert-butyl 5-fluoro-3-iodo-pyrrolo[2,3-b]pyridine-1-carboxylate (CAS No. 928653-78-5)

The compound tert-butyl 5-fluoro-3-iodo-pyrrolo[2,3-b]pyridine-1-carboxylate (CAS No. 928653-78-5) is a highly specialized heterocyclic molecule that has garnered significant attention in pharmaceutical and agrochemical research. Its unique structural features, including the pyrrolo[2,3-b]pyridine core, fluoro substitution, and iodo functional group, make it a versatile intermediate for the synthesis of bioactive compounds. Researchers are particularly interested in its potential applications in drug discovery, especially in the development of kinase inhibitors and antiviral agents.

In recent years, the demand for fluorinated pyrrolopyridines has surged due to their enhanced metabolic stability and binding affinity in medicinal chemistry. The presence of the tert-butyl carboxylate moiety in this compound further improves its solubility and handling properties, making it a preferred choice for laboratory-scale reactions. A common query among scientists is how this compound compares to other halogenated pyrrolopyridine derivatives in terms of reactivity and synthetic utility. Studies suggest that the 5-fluoro-3-iodo substitution pattern offers a balance between electronic effects and steric hindrance, facilitating selective cross-coupling reactions.

From an industrial perspective, CAS 928653-78-5 is often discussed in the context of scalable synthesis and cost-effective production methods. Innovations in catalytic iodination and fluorination techniques have streamlined its manufacturing process, addressing concerns about yield and purity. Environmental sustainability is another hot topic, with researchers exploring greener solvents and catalysts for its preparation. The compound’s role in high-throughput screening libraries also aligns with the growing trend of fragment-based drug design, where small molecular fragments are used to build larger, more complex therapeutics.

Analytical characterization of tert-butyl 5-fluoro-3-iodo-pyrrolo[2,3-b]pyridine-1-carboxylate typically involves advanced techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography. These methods confirm the regioisomeric purity and stability of the compound, which are critical for reproducibility in research. FAQs in online forums often revolve around storage conditions—recommendations include keeping the compound in a cool, dry environment under inert atmosphere to prevent degradation of the iodo group.

Looking ahead, the compound’s potential extends beyond pharmaceuticals. Its electron-deficient pyrrolopyridine scaffold is being investigated in materials science, particularly in the design of organic semiconductors and light-emitting diodes (OLEDs). This interdisciplinary appeal underscores the importance of CAS 928653-78-5 as a building block in both life sciences and advanced technology. As synthetic methodologies evolve, this compound is poised to play a pivotal role in addressing unmet challenges in precision medicine and sustainable chemistry.

• 1345828-16-1(tert-butyl 6-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate)
• 1228183-72-9(tert-butyl 3-iodo-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine-1-carboxylate)
• 1198097-29-8(tert-Butyl 3-Iodo-5-methyl-1H-pyrrolo2,3-bpyridine-1-carboxylate)
• 192189-18-7(1-Boc-3-Iodo-7-azaindole)
• 1254926-83-4(Tert-butyl 3-iodo-4-methoxy-1H-pyrrolo[2,3-B]pyridine-1-carboxylate)
• 1203565-82-5(1H-Pyrrolo[2,3-b]pyridine-1-carboxylic acid, 4-chloro-3-iodo-, 1,1-dimethylethyl ester)
• 1823266-40-5(Tert-butyl 5-cyano-3-iodopyrrolo[2,3-b]pyridine-1-carboxylate)
• 928653-77-4(5-Fluoro-pyrrolo2,3-bpyridine-1-carboxylic acid tert-butyl ester)
• 928653-79-6(5-CHLORO-3-IODO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER)
• 928653-81-0(5-Bromo-3-iodo-pyrrolo2,3-bpyridine-1-carboxylic acid tert-butyl ester)