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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazinanes Piperazines Piperazine carboxylic acids and derivatives

Comprehensive Guide to (R)-1-BOC-3-BUTYL-PIPERAZINE (CAS No. 928025-59-6): Properties, Applications, and Market Insights

(R)-1-BOC-3-BUTYL-PIPERAZINE (CAS No. 928025-59-6) is a chiral piperazine derivative widely used in pharmaceutical and chemical research. This compound features a tert-butoxycarbonyl (BOC) protecting group and a butyl side chain, making it a versatile intermediate in organic synthesis. Researchers and manufacturers value its role in asymmetric synthesis and drug development, particularly for its potential in creating bioactive molecules.

The chemical properties of (R)-1-BOC-3-BUTYL-PIPERAZINE include a molecular formula of C₁₃H₂₆N₂O₂ and a molecular weight of 242.36 g/mol. Its chiral center at the 3-position makes it valuable for enantioselective reactions, a hot topic in modern medicinal chemistry. The BOC group enhances stability during synthesis, while the butyl chain contributes to lipophilicity, a key factor in drug design for improved bioavailability.

In pharmaceutical applications, this compound serves as a building block for central nervous system (CNS) drugs and GPCR-targeting molecules, aligning with current trends in neurodegenerative disease research. Its structural features make it particularly useful for developing dopamine receptor modulators and serotonin antagonists, addressing growing demand in mental health therapeutics. Recent studies highlight its potential in creating novel antidepressants and anti-anxiety medications, responding to increased global mental health awareness.

The synthetic utility of (R)-1-BOC-3-BUTYL-PIPERAZINE extends to peptide chemistry and catalysis research. Its compatibility with various coupling reagents makes it valuable for solid-phase peptide synthesis (SPPS), a technique gaining traction in bioconjugation and antibody-drug conjugate development. The compound's stability under diverse reaction conditions supports its use in flow chemistry applications, an emerging field in sustainable pharmaceutical manufacturing.

From a market perspective, demand for chiral piperazine derivatives like (R)-1-BOC-3-BUTYL-PIPERAZINE continues to grow, driven by expanding biopharmaceutical research and personalized medicine initiatives. The compound's CAS registry (928025-59-6) ensures precise identification in global chemical commerce, while its high purity grades (typically ≥97%) meet stringent regulatory requirements for drug development. Current market analysis shows increasing procurement from contract research organizations (CROs) and academic research institutions.

Quality control for (R)-1-BOC-3-BUTYL-PIPERAZINE typically involves HPLC analysis, chiral purity determination, and residual solvent testing – all critical parameters for pharmaceutical applications. Storage recommendations usually suggest 2-8°C under inert atmosphere to maintain stability, with special attention to moisture sensitivity due to the BOC protecting group. These handling protocols align with current good manufacturing practice (GMP) standards in the pharmaceutical industry.

Recent innovations in green chemistry have explored more sustainable routes to synthesize piperazine derivatives, including (R)-1-BOC-3-BUTYL-PIPERAZINE. Researchers are investigating biocatalytic methods and continuous flow processes to reduce environmental impact, responding to the pharmaceutical industry's sustainability goals. These developments complement growing interest in AI-assisted drug discovery, where such building blocks play crucial roles in virtual screening and molecular design.

For researchers sourcing (R)-1-BOC-3-BUTYL-PIPERAZINE, key considerations include supplier reliability, batch-to-batch consistency, and technical documentation quality. The compound's applications in high-throughput screening and combinatorial chemistry make these factors particularly important. Many suppliers now provide custom synthesis services and scale-up capabilities to support various research and development needs.

Looking ahead, the scientific community anticipates expanded applications of (R)-1-BOC-3-BUTYL-PIPERAZINE in proteolysis targeting chimera (PROTAC) development and targeted protein degradation research – two rapidly growing areas in drug discovery. Its structural features position it well for creating E3 ligase-binding moieties, addressing one of the most searched topics in contemporary medicinal chemistry literature.

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