Production Method 1

16647-04-4

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Ethanol ;  2 h, 1 MPa, 40 °C

Reference

Application of single atom metal loaded catalyst in selective hydrogenation reaction

, China, , ,

Production Method 2

110-93-0

928-68-7

Reaction Conditions

1.1 Reagents: Sodium triethylborohydride Catalysts: Di-μ-hydroxyhexa-μ3-hydroxyhexakis[μ6-[[4′,4′′′,4′′′′′,4′′′′′′′-methanetetraylte… (reaction products with cobalt dichloride) Solvents: Tetrahydrofuran ;  1 h, rt
1.2 Reagents: Hydrogen Solvents: Tetrahydrofuran ;  18 h, 40 bar, rt

Reference

Single-Site Cobalt Catalysts at New Zr8(μ2-O)8(μ2-OH)4 Metal-Organic Framework Nodes for Highly Active Hydrogenation of Alkenes, Imines, Carbonyls, and Heterocycles

Ji, Pengfei; Manna, Kuntal; Lin, Zekai; Urban, Ania; Greene, Francis X.; et al, Journal of the American Chemical Society, 2016, 138(37), 12234-12242

Production Method 3

61652-37-7

928-68-7

Reaction Conditions

1.1 Reagents: Oxalic acid Solvents: Water

Reference

Synthesis of 2-cyclohexyl-6-methylheptane

Hey, D. H.; Morris, D. S., Journal of the Chemical Society, 1948, 48, 48-9

Production Method 4

110-93-0

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ;  11.4 h, 2 bar, rt → 60 °C

Reference

Process for preparation of 3,7-dimethyl-1-octen-3-ol

, World Intellectual Property Organization, , ,

Production Method 5

4730-22-7

928-68-7

Reaction Conditions

1.1 Reagents: Acetonitrile ,  Water ,  Fluorine Solvents: Chloroform ;  30 min, 0 °C

Reference

Fluorine

Kotun, Stefan P., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, 1, 1-4

Production Method 6

928-68-7

539-66-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydrogen Catalysts: Palladium Solvents: Methyl isobutyl ketone ,  Water ;  15 bar, rt; rt → 105 °C
1.2 3 h, 105 - 110 °C; 1 h, 20 bar, 105 - 110 °C

Reference

Improved process for the production of 6-methylheptan-2-one

, World Intellectual Property Organization, , ,

Production Method 7

110-93-0

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Dichloromethane ;  1 h, 1 atm, rt

Reference

Palladium-catalyzed hydrogenations in dichloromethane

Mason, David J.; Timofeyenko, Yegor G.; Jagadish, Bhumasamudram; Mash, Eugene A., Synthetic Communications, 2022, 52(18), 1825-1833

Production Method 8

928-68-7

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydrogen Catalysts: Palladium Solvents: Glycerol ,  Water ;  rt → 120 °C; 15 bar, 120 °C
1.2 3 h, 120 - 125 °C

Reference

Process for production of 6-methylheptanone

, World Intellectual Property Organization, , ,

Production Method 9

1569-60-4

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen bromide

Reference

Studies on aromatic sesquiterpenes. IX. Synthesis of curcuphenol and 8-hydroxycalamenene

Tanaka, Juichi; Nobutani, Kimiaki; Adachi, Kazuo, Nippon Kagaku Kaishi, 1988, (7), 1065-73

Production Method 10

110-93-0

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Sodium triethylborohydride (reaction products with Zr-MTBC-CoCl) Solvents: Tetrahydrofuran ;  0.75 d, 40 bar, 40 °C

Reference

Stabilization of active metal catalysts at metal-organic framework nodes for highly efficient organic transformations

, World Intellectual Property Organization, , ,

Production Method 11

110-93-0

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium ,  TentaGel S-NH2 Solvents: Ethanol ;  5 h, 10 bar, 85 °C

Reference

A novel nano-palladium catalyst for continuous-flow chemoselective hydrogenation reactions

Goszewska, Ilona; Gizinski, Damian; Zienkiewicz-Machnik, Malgorzata; Lisovytskiy, Dmytro; Nikiforov, Kostyantyn; et al, Catalysis Communications, 2017, 94, 65-68

Production Method 12

4730-22-7

928-68-7

Reaction Conditions

1.1 Reagents: 3,3-Dimethyl-1-butene Catalysts: (TB-5-11)-[2,6-Bis[[bis(1,1-dimethylethyl)phosphino-κP]methyl]phenyl-κC]dihydroi… Solvents: Toluene

Reference

Selective dehydrogenation of alcohols and diols catalyzed by a dihydrido iridium PCP pincer complex

Morales-Morales, David; Redon, Rocio; Wang, Zhaohui; Lee, Do W.; Yung, Cathleen; et al, Canadian Journal of Chemistry, 2001, 79, 823-829

Production Method 13

2009-74-7

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium

Reference

Process for producing 6-methyl-3-hepten-2-one and 6-methyl-2-heptanone analogs, and process for producing phyton or isophytol

, European Patent Organization, , ,

Production Method 14

116-11-0

928-68-7

Reaction Conditions

1.1 Catalysts: Diphenyl phosphate ;  rt → 80 °C; 3 h, 80 °C; 80 °C → rt
1.2 Reagents: Hydrogen ,  2,8,9-Tris(2-methylpropyl)-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane Catalysts: Palladium ;  neutralized, 2 MPa, rt → 40 °C; 2 h, 40 °C

Reference

Preparation of δ-methyl ketone by one-pot method

, China, , ,

Production Method 15

110-93-0

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Tetrahydrofuran

Reference

Study on the selective hydrogenation of isophorone

Xu, Lei; Sun, Shaoyin; Zhang, Xing; Gao, Haofei; Wang, Wei, RSC Advances, 2021, 11(8), 4465-4471

Production Method 16

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Sodium hydroxide ,  Palladium Solvents: Water

Reference

Process for the production of 6-methylheptan-2-one or homologs from acetone and isovaleraldehyde or homologs.

, United States, , ,

Production Method 17

4730-22-7

928-68-7

Reaction Conditions

1.1 Reagents: Iodobenzene diacetate Catalysts: Ruthenium, [μ-[[2,2′-bipyridine]-5,5′-dicarboxylato(2-)-κN1,κN1′:κO5]]trichloro(… (ruthenium chloride-deficient) Solvents: Dichloromethane ;  2 h, 40 °C

Reference

Ruthenium Complexation in an Aluminium Metal-Organic Framework and its Application in Alcohol Oxidation Catalysis

Carson, Fabian; Agrawal, Santosh; Gustafsson, Mikaela; Bartoszewicz, Agnieszka; Moraga, Francisca; et al, Chemistry - A European Journal, 2012, 18(48), 15337-15344

Production Method 18

4730-22-7

928-68-7

Reaction Conditions

1.1 Reagents: Sodium hypochlorite Catalysts: Tetrabutylammonium bromide Solvents: Ethyl acetate ,  Water ;  30 min, rt

Reference

Continuous Flow Oxidation of Alcohols and Aldehydes Utilizing Bleach and Catalytic Tetrabutylammonium Bromide

Leduc, Andrew B.; Jamison, Timothy F., Organic Process Research & Development, 2012, 16(5), 1082-1089

Production Method 19

4730-22-7

928-68-7

Reaction Conditions

1.1 Reagents: Hypofluorous acid, acetonitrile (1:1) Solvents: Chloroform ,  Water

Reference

HOF·CH3CN [hypofluorous acid·acetonitrile] made directly from fluorine and water, as an ecologically friendly oxidizing reagent

Rozen, Shlomo; Bareket, Yifat; Kol, Moshe, Tetrahedron, 1993, 49(36), 8169-78

Production Method 20

110-93-0

928-68-7

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Nickel Solvents: Methanol ;  20 h, 1 mm Hg, 80 °C

Reference

Chemoselective Hydrogenation of Olefins Using a Nanostructured Nickel Catalyst

Klarner, Mara; Bieger, Sandra; Drechsler, Markus; Kempe, Rhett, Zeitschrift fuer Anorganische und Allgemeine Chemie, 2021, 647(22), 2157-2161

6-Methyl-2-heptanone Raw materials

• 3-Hepten-2-one,6-methyl-
• 6-methylhepta-3,5-dien-2-one
• Hydrazinecarboxamide, 2-(1,5-dimethylhexylidene)-
• 6-Methyl-hepten-2-one
• 2-Methoxypropene
• Sulcatol
• 6-Methyl-2-heptanol

6-Methyl-2-heptanone Preparation Products

• Sodium Isovalerate (539-66-2)
• 6-Methyl-2-heptanone (928-68-7)

• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
  Gang Pan,Yi-jie Bao,Jie Xu,Tao Liu,Cheng Liu,Yan-yan Qiu,Xiao-jing Shi,Hui Yu,Ting-ting Jia,Xia Yuan,Ze-ting Yuan,Yi-jun Cao RSC Adv., 2016,6, 42109-42119
• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 5. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 61549-01-7(4-Tetradecanone, 2-methyl-)
• 61548-99-0(4-Dodecanone, 2-methyl-)
• 626-33-5(2-Methylheptan-4-one)
• 6627-76-5(4-Nonanone, 2-methyl-)
• 6628-29-1(7-Ethyl-2-methyl-4-nonanone)
• 6137-06-0(4-methylheptan-2-one)
• 6976-00-7(7-Ethyl-2-methyl-4-undecanone)
• 624-42-0(3-Heptanone, 6-methyl-)
• 61549-00-6(4-Tridecanone, 2-methyl-)
• 623-56-3(Ethyl Isobutyl Ketone)