Production Method 1

695-34-1

926294-07-7

Reaction Conditions

1.1 Reagents: 1,3-Dibromo-5,5-dimethylhydantoin Solvents: Dichloromethane ;  rt → -10 °C; -10 °C; -10 °C → rt; 2 h, rt
1.2 Reagents: Sodium nitrite ,  Bromine ,  Hydrogen bromide Solvents: Water ;  0 °C; 0 °C → rt; 1.5 h, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  neutralized
1.4 Reagents: Butyllithium Solvents: Diethyl ether ,  Benzene ;  rt → -78 °C; -78 °C; 1 h, -78 °C
1.5 1 h, -78 °C; -78 °C → rt; 1 h, rt

Reference

Substituted imidazolidinones and related compounds as chemokine receptor binding compounds and their preparation, pharmaceutical compositions and use in the treatment of infection of target cells by human immunodeficiency virus

, World Intellectual Property Organization, , ,

Production Method 2

3430-26-0

926294-07-7

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ;  30 min, -78 °C
1.2 3 h, -78 °C

Reference

Heterocyclic compound intermediate, preparation method therefor and application thereof

, World Intellectual Property Organization, , ,

Production Method 3

942206-07-7

926294-07-7

Reaction Conditions

1.1 Reagents: Chloro(1-methylethyl)magnesium Solvents: Tetrahydrofuran ;  30 min, -78 °C
1.2 -78 °C → rt; 1 h, rt

Reference

Preparation of 1-[N-(1,4-dihydropyridazine-linked acyl)glycyl]pyrrolidine compounds as CGRP receptor antagonists

, World Intellectual Property Organization, , ,

6-Bromo-4-methylpyridine-3-carbaldehyde Raw materials

• 2-Bromo-5-iodo-4-methylpyridine
• 2,5-Dibromo-4-methylpyridine
• Aminopicoline

6-Bromo-4-methylpyridine-3-carbaldehyde Preparation Products

• 6-Bromo-4-methylpyridine-3-carbaldehyde (926294-07-7)

• 1. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 2. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 3. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 4. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 5. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459

• 2016-99-1(2,6-dibromopyridine-4-carboxylic acid)
• 128071-75-0(2-Bromonicotinaldehyde)
• 6311-35-9(6-bromopyridine-3-carboxylic acid)
• 260417-56-9(Methanone,(2-bromo-4-pyridinyl)-3-pyridinyl-)
• 118289-17-1(2-bromopyridine-4-carbaldehyde)
• 149806-06-4(6-Bromopyridine-3-carboxaldehyde)
• 66572-56-3(2-bromopyridine-4-carboxylic acid)
• 316800-46-1(2,6-Dibromoisonicotinaldehyde)
• 66533-31-1(2-bromo-4,5-dimethylpyridine)
• 926293-55-2(6-Bromo-2-methylnicotinaldehyde)