- Preparation of macrocyclic sulfonamides as MEK inhibitors for the treatment of cardiomyopathy and other diseases, United States, , ,
Cas no 925890-13-7 (2-nitro-3,4,5-trifluoroanisole)
925890-13-7 structure
Product Name:2-nitro-3,4,5-trifluoroanisole
CAS No:925890-13-7
MF:C7H4F3NO3
MW:207.106772422791
MDL:MFCD09025341
CID:796807
PubChem ID:26596869
Update Time:2024-10-26
2-nitro-3,4,5-trifluoroanisole Chemical and Physical Properties
Names and Identifiers
-
- 1,2,3-Trifluoro-5-methoxy-4-nitrobenzene
- 2-Nitro-3,4,5-trifluoroanisole
- Benzene,1,2,3-trifluoro-5-methoxy-4-nitro-
- 1,2,3-trifluoro-5-methoxy-4-nitro-benzene
- PubChem14032
- ZSOYSDLZDZGEFC-UHFFFAOYSA-N
- FCH1390154
- AS02408
- CM11795
- AM82871
- 123-Trifluoro-5-methoxy-4-nitrobenzene
- PC305001
- ST2414733
- AX8036464
- AB0007753
- W9551
- 3,4,5-trifluoro-2-nitro-phenyl methyl ether
- S-
- 1,2,3-Trifluoro-5-methoxy-4-nitrobenzene (ACI)
- DTXSID90650159
- SY022947
- AKOS015890592
- SCHEMBL11909148
- CS-0008646
- 925890-13-7
- 1 pound not2 pound not3-Trifluoro-5-methoxy-4-nitrobenzene
- DS-13496
- MFCD09025341
- DB-079352
- 2-nitro-3,4,5-trifluoroanisole
-
- MDL： MFCD09025341
- Inchi： 1S/C7H4F3NO3/c1-14-4-2-3(8)5(9)6(10)7(4)11(12)13/h2H,1H3
- InChI Key： ZSOYSDLZDZGEFC-UHFFFAOYSA-N
- SMILES： [O-][N+](C1C(OC)=CC(F)=C(F)C=1F)=O
Computed Properties
- Exact Mass: 207.014
- Monoisotopic Mass: 207.014
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 6
- Heavy Atom Count: 14
- Rotatable Bond Count: 1
- Complexity: 223
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 55
- XLogP3: 2
Experimental Properties
- Color/Form: Pale-yellow to Yellow-brown Liquid
- Density: 1.5±0.1 g/cm3
- Melting Point: No data available
- Boiling Point: 258℃ at 760 mmHg
- Flash Point: 109.8±25.9 °C
- Refractive Index: 1.484
- Vapor Pressure: 0.0±0.5 mmHg at 25°C
2-nitro-3,4,5-trifluoroanisole Security Information
- Signal Word：Warning
- Hazard Statement： H302;H315;H320;H335
- Warning Statement： P264;P270;P301+P312;P330
- Safety Instruction： H302 (92.31%) H312 (92.31%) H318 (92.31%)
- Storage Condition：2-8 °C
2-nitro-3,4,5-trifluoroanisole Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 040571-1g |
1,2,3-Trifluoro-5-methoxy-4-nitrobenzene |
925890-13-7 | 97% | 1g |
￡31.00 | 2022-03-01 | |
| Fluorochem | 040571-5g |
1,2,3-Trifluoro-5-methoxy-4-nitrobenzene |
925890-13-7 | 97% | 5g |
￡129.00 | 2022-03-01 | |
| Fluorochem | 040571-10g |
1,2,3-Trifluoro-5-methoxy-4-nitrobenzene |
925890-13-7 | 97% | 10g |
￡206.00 | 2022-03-01 | |
| Fluorochem | 040571-25g |
1,2,3-Trifluoro-5-methoxy-4-nitrobenzene |
925890-13-7 | 97% | 25g |
￡397.00 | 2022-03-01 | |
| AstaTech | 66524-1/G |
1,2,3-TRIFLUORO-5-METHOXY-4-NITROBENZENE |
925890-13-7 | 97% | 1g |
$27 | 2023-09-16 | |
| AstaTech | 66524-5/G |
1,2,3-TRIFLUORO-5-METHOXY-4-NITROBENZENE |
925890-13-7 | 97% | 5g |
$99 | 2023-09-16 | |
| AstaTech | 66524-25/G |
1,2,3-TRIFLUORO-5-METHOXY-4-NITROBENZENE |
925890-13-7 | 97% | 25g |
$337 | 2023-09-16 | |
| Chemenu | CM255805-10g |
1,2,3-Trifluoro-5-methoxy-4-nitrobenzene |
925890-13-7 | 95+% | 10g |
$259 | 2021-06-16 | |
| Chemenu | CM255805-25g |
1,2,3-Trifluoro-5-methoxy-4-nitrobenzene |
925890-13-7 | 95+% | 25g |
$552 | 2021-06-16 | |
| Ambeed | A221769-1g |
1,2,3-Trifluoro-5-methoxy-4-nitrobenzene |
925890-13-7 | 98% | 1g |
$9.0 | 2024-04-15 |
2-nitro-3,4,5-trifluoroanisole Production Method
Production Method 1
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Acetone ; 2 h, rt → reflux
Reference
Production Method 2
Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Acetone ; 2 h, rt → reflux; cooled
Reference
- Sulfonamide derivatives as MEK inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases, World Intellectual Property Organization, , ,
Production Method 3
Reaction Conditions
Reference
- Mek inhibitors useful in the treatment of diseases, United States, , ,
2-nitro-3,4,5-trifluoroanisole Raw materials
2-nitro-3,4,5-trifluoroanisole Preparation Products
2-nitro-3,4,5-trifluoroanisole Related Literature
-
M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
-
Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
-
Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
-
Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
925890-13-7 (2-nitro-3,4,5-trifluoroanisole) Related Products
- 641-49-6(3-Fluoro-2-nitroanisole)
- 66684-64-8(1,2-Difluoro-4-methoxy-5-nitrobenzene)
- 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
- 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
- 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
- 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
- 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
- 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
- 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
- 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
Recommended suppliers
Zouping Mingyuan Import and Export Trading Co., Ltd
Gold Member
Audited Supplier
CN Supplier
Reagent
Shandong Feiyang Chemical Co., Ltd
Gold Member
Audited Supplier
CN Supplier
Bulk
Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd.
Gold Member
Audited Supplier
CN Supplier
Reagent
PRIBOLAB PTE.LTD
Gold Member
Audited Supplier
CN Supplier
Reagent
Zhangzhou Sinobioway Peptide Co.,Ltd.
Gold Member
Audited Supplier
CN Supplier
Reagent
